Rifampin
Rifadin, Rifamate, Rifampin, Rifater, Rimactane (rifampin) is a small molecule pharmaceutical. Rifampin was first approved as Rifamate on 1982-01-01. It is used to treat aids-related opportunistic infections, bacterial infections, bacterial meningitis, brucellosis, and haemophilus infections amongst others in the USA. It is known to target solute carrier organic anion transporter family member 1A2, solute carrier organic anion transporter family member 1B1, solute carrier organic anion transporter family member 1B3, and nuclear receptor subfamily 1 group I member 2.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Rifadin, Rifampin, Rimactane (discontinued: Rifadin, Rifampin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Rifampin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RIMACTANE | Oxford Pharmaceuticals | N-050429 RX | 1982-01-01 | 1 products |
| RIFADIN | Sanofi | N-050627 RX | 1989-05-25 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| rifadin | 2007-07-16 | |
| rifadin iv | New Drug Application | 2024-10-18 |
| rifadin iv novaplus | New Drug Application | 2024-10-28 |
| rifadin rifadin iv | New Drug Application | 2021-12-01 |
| rifadin rifadin iv novaplus | New Drug Application | 2017-05-04 |
| rifampin | ANDA | 2024-09-17 |
Indications
FDA
EMA
Agency Specific
FDA
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Patent Expiration
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ATC Codes
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AB: Antibiotics, antitubercular
— J04AB02: Rifampicin
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM02: Rifampicin and isoniazid
— J04AM05: Rifampicin, pyrazinamide and isoniazid
— J04AM06: Rifampicin, pyrazinamide, ethambutol and isoniazid
— J04AM07: Rifampicin, ethambutol and isoniazid
— J04B: Drugs for treatment of lepra
— J04BA: Drugs for treatment of lepra
— J04BA50: Dapsone and rifampicin
— J04BA51: Dapsone, rifampicin and clofazimine
HCPCS
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Clinical
Clinical Trials
647 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 34 | 100 | 61 | 37 | 69 | 279 |
| Healthy volunteers/patients | — | — | — | 113 | 1 | 1 | 1 | 5 | 120 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | 6 | 52 | 26 | 7 | 17 | 98 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 10 | 20 | 15 | 13 | 12 | 65 |
| Infections | D007239 | EFO_0000544 | — | 4 | 6 | 17 | 9 | 16 | 51 |
| Communicable diseases | D003141 | — | — | 1 | 3 | 9 | 5 | 13 | 31 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | — | 4 | 6 | 2 | 12 | 23 |
| Drug interactions | D004347 | — | — | 17 | 1 | — | 3 | 1 | 21 |
| Latent tuberculosis | D055985 | — | Z22.7 | 2 | 4 | 9 | 3 | 6 | 21 |
| Hiv | D006678 | — | — | 4 | 4 | 5 | 3 | 4 | 19 |
Show 54 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Meningeal tuberculosis | D014390 | — | A17.0 | 1 | 8 | 3 | — | — | 10 |
| Meningitis | D008581 | HP_0001287 | G03 | — | 7 | 3 | — | — | 9 |
| Coinfection | D060085 | — | — | — | 3 | 2 | — | 2 | 7 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 4 | 2 | — | — | 5 |
| Pneumonia | D011014 | EFO_0003106 | — | 1 | 2 | 2 | — | — | 4 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | — | 2 | — | 1 | 4 |
| Buruli ulcer | D054312 | EFO_1001281 | A31.1 | — | 3 | 2 | — | 1 | 4 |
| Uveitis | D014605 | HP_0000554 | H20.9 | — | 1 | 1 | — | 1 | 3 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 1 | — | 1 | — | — | 2 |
| Hydrocephalus | D006849 | HP_0000238 | G91 | — | — | 1 | — | 1 | 2 |
Show 30 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 4 | 1 | — | — | — | 5 |
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | 2 | 2 | — | — | 1 | 4 |
| Chronic renal insufficiency | D051436 | — | N18 | 2 | 1 | — | — | — | 3 |
| Pulmonary sarcoidosis | D017565 | DOID_13406 | D86.0 | 1 | 1 | — | — | — | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | 1 | — | — | — | 2 |
| Newborn infant diseases | D007232 | — | — | 1 | 1 | — | — | — | 2 |
| Hypercalcemia | D006934 | HP_0003072 | E83.52 | 1 | 1 | — | — | — | 2 |
| Inborn errors metabolism | D008661 | — | — | 1 | 1 | — | — | — | 2 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | — | — | 1 | 2 |
| Onchocerciasis | D009855 | EFO_0007402 | B73 | — | 1 | — | — | — | 1 |
Show 10 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 31 | — | — | — | — | 31 |
| Lymphoma | D008223 | — | C85.9 | 10 | — | — | — | — | 10 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 7 | — | — | — | — | 7 |
| Non-small-cell lung carcinoma | D002289 | — | — | 6 | — | — | — | — | 6 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 3 | — | — | — | — | 3 |
| Biological availability | D001682 | — | — | 2 | — | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 2 | — | — | — | — | 2 |
| Melanoma | D008545 | — | — | 2 | — | — | — | — | 2 |
| Hodgkin disease | D006689 | — | C81 | 2 | — | — | — | — | 2 |
| Bacterial infections | D001424 | — | A49 | 1 | — | — | — | 1 | 2 |
Show 46 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Critical illness | D016638 | — | — | — | — | — | — | 2 | 2 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | — | — | 2 | 2 |
| Body weight | D001835 | EFO_0004338 | — | — | — | — | — | 2 | 2 |
| Bone diseases | D001847 | — | M89.9 | — | — | — | — | 1 | 1 |
| Infectious bone diseases | D001850 | — | — | — | — | — | — | 1 | 1 |
| Acinetobacter infections | D000151 | EFO_1000792 | — | — | — | — | — | 1 | 1 |
| Scrub typhus | D012612 | EFO_0007480 | A75.3 | — | — | — | — | 1 | 1 |
| Epidemic louse-borne typhus | D014438 | EFO_0007182 | A75 | — | — | — | — | 1 | 1 |
| Birth weight | D001724 | EFO_0004344 | — | — | — | — | — | 1 | 1 |
| Granuloma | D006099 | — | — | — | — | — | — | 1 | 1 |
Show 18 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rifampin |
| INN | rifampicin |
| Description | Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease. It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended" for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended. Rifampicin may be given either by mouth or intravenously.
|
| Classification | Small molecule |
| Drug class | tricyclic compounds; antibiotics (rifamycin derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C |
Identifiers
| PDB | — |
| CAS-ID | 13292-46-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL374478 |
| ChEBI ID | 28077 |
| PubChem CID | 5381226 |
| DrugBank | DB01045 |
| UNII ID | VJT6J7R4TR (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
SLCO1A2
SLCO1A2
SLCO1B1
SLCO1B1
SLCO1B3
SLCO1B3
NR1I2
NR1I2
Organism
Homo sapiens
Gene name
SLCO1A2
Gene synonyms
OATP, OATP1, OATP1A2, SLC21A3
NCBI Gene ID
Protein name
solute carrier organic anion transporter family member 1A2
Protein synonyms
OATP-1, OATP-A, organic anion transporting polypeptide A, Organic anion-transporting polypeptide 1, Sodium-independent organic anion transporter, solute carrier family 21 (organic anion transporter), member 3, Solute carrier family 21 member 3
Uniprot ID
Mouse ortholog
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—
Variants
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Financial
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Estimated US medical usage
Rifampin
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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17,780 adverse events reported
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