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Drug ReportsRifampin
Rifampin
Rifadin, Rifamate, Rifampin, Rifater, Rimactane (rifampin) is a small molecule pharmaceutical. Rifampin was first approved as Rifamate on 1982-01-01. It is used to treat aids-related opportunistic infections, bacterial infections, bacterial meningitis, brucellosis, and haemophilus infections amongst others in the USA. It is known to target solute carrier organic anion transporter family member 1A2, solute carrier organic anion transporter family member 1B1, solute carrier organic anion transporter family member 1B3, and nuclear receptor subfamily 1 group I member 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
nervous system diseasesD009422
immune system diseasesD007154
Trade Name
FDA
EMA
Rifadin, Rifampin, Rimactane (discontinued: Rifadin, Rifampin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Rifampin
Tradename
Company
Number
Date
Products
RIMACTANEOxford PharmaceuticalsN-050429 RX1982-01-01
1 products
RIFADINSanofiN-050627 RX1989-05-25
1 products, RLD, RS
Show 1 discontinued
Isoniazid
+
Pyrazinamide
+
Rifampin
Tradename
Company
Number
Date
Products
RIFATERSanofiN-050705 DISCN1994-05-31
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
mycobutinNew Drug Application2024-12-24
priftinNew Drug Application2025-05-21
rifabutinNDA authorized generic2025-09-30
rifadin2007-07-16
rifadin ivNew Drug Application2025-05-14
rifadin iv novaplusNew Drug Application2025-05-14
rifadin rifadin ivNew Drug Application2021-12-01
rifadin rifadin iv novaplusNew Drug Application2017-05-04
rifampinANDA2025-09-19
taliciaNew Drug Application2024-05-01
Show 1 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AB: Antibiotics, antitubercular
— J04AB02: Rifampicin
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM02: Rifampicin and isoniazid
— J04AM05: Rifampicin, pyrazinamide and isoniazid
— J04AM06: Rifampicin, pyrazinamide, ethambutol and isoniazid
— J04AM07: Rifampicin, ethambutol and isoniazid
— J04B: Drugs for treatment of lepra
— J04BA: Drugs for treatment of lepra
— J04BA50: Dapsone and rifampicin
— J04BA51: Dapsone, rifampicin and clofazimine
HCPCS
No data
Clinical
Clinical Trials
702 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TuberculosisD014376EFO_0000774A15-A193581502962239
Healthy volunteers/patients———1181115125
Pulmonary tuberculosisD014397EFO_1000049A1565230617100
Hiv infectionsD015658EFO_0000764B2092116121264
InfectionsD007239EFO_0000544—361041234
Multidrug-resistant tuberculosisD018088EFO_0007381——7921127
Communicable diseasesD003141———3631022
Drug interactionsD004347——181—3122
Latent tuberculosisD055985—Z22.73484622
Acquired immunodeficiency syndromeD000163EFO_0000765B202464721
Show 48 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Meningeal tuberculosisD014390—A17.0193—112
CoinfectionD060085———32—27
Alzheimer diseaseD000544EFO_0000249F031—3—15
Aids-related opportunistic infectionsD017088————1—45
MeningitisD008581EFO_0000584G03—21—14
Buruli ulcerD054312EFO_1001281A31.1—32—14
PneumoniaD011014EFO_0003106J18121——3
SepsisD018805EFO_0001420A41.91—1—13
UveitisD014605EFO_1001231H20.9—11—13
Immunologic deficiency syndromesD007153—D84.9——2—13
Show 34 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C80331———34
Myeloid leukemia acuteD015470—C92.077———11
LymphomaD008223—C85.981———9
Myelodysplastic syndromesD009190—D4635———7
MelanomaD008545——43———6
PharmacokineticsD010599——41———5
RecurrenceD012008——42———5
SarcoidosisD012507EFO_0000690D80-D8922——14
Myeloproliferative disordersD009196—D47.131———4
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.013———4
Show 68 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228—C85.98————8
Non-small-cell lung carcinomaD002289——6————6
Neoplasm metastasisD009362EFO_0009708—3————3
Primary myelofibrosisD055728—D47.42————2
Biological availabilityD001682——2————2
ThrombosisD013927——2————2
Bacterial infectionsD001424—A491———12
Respiratory syncytial virus infectionsD018357EFO_1001413—2————2
Parkinson diseaseD010300EFO_0002508G202————2
RhinoscleromaD012226EFO_0007470—2————2
Show 43 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Critical illnessD016638——————22
Body weightD001835EFO_0004338—————22
Metabolic syndromeD024821EFO_0000195E88.810————22
Bone diseasesD001847—M89.9————11
Infectious bone diseasesD001850——————11
Acinetobacter infectionsD000151EFO_1000792—————11
Scrub typhusD012612EFO_0007480A75.3————11
Epidemic louse-borne typhusD014438EFO_0007182A75————11
Birth weightD001724EFO_0004344—————11
GranulomaD006099——————11
Show 19 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRifampin
INNrifampicin
Description
Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease. It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended" for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended. Rifampicin may be given either by mouth or intravenously.
Classification
Small molecule
Drug classtricyclic compounds; antibiotics (rifamycin derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C
Identifiers
PDB—
CAS-ID13292-46-1
RxCUI—
ChEMBL IDCHEMBL374478
ChEBI ID28077
PubChem CID5381226
DrugBankDB01045
UNII IDVJT6J7R4TR (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SLCO1A2
SLCO1A2
SLCO1B1
SLCO1B1
SLCO1B3
SLCO1B3
NR1I2
NR1I2
Organism
Homo sapiens
Gene name
SLCO1A2
Gene synonyms
OATP, OATP1, OATP1A2, SLC21A3
NCBI Gene ID
Protein name
solute carrier organic anion transporter family member 1A2
Protein synonyms
OATP-1, OATP-A, organic anion transporting polypeptide A, Organic anion-transporting polypeptide 1, Sodium-independent organic anion transporter, solute carrier family 21 (organic anion transporter), member 3, Solute carrier family 21 member 3
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Rifampin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 48,414 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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36,446 adverse events reported
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