Rifabutin
Mycobutin, Rifabutin, Talicia (rifabutin) is a small molecule pharmaceutical. Rifabutin was first approved as Mycobutin on 1992-12-23. It is used to treat mycobacterium avium-intracellulare infection, mycobacterium infections, and pulmonary tuberculosis in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| respiratory tract diseases | D012140 |
Trade Name
FDA
EMA
Mycobutin, Rifabutin
CombinationsTalicia
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amoxicillin
+
Omeprazole magnesium
+
Rifabutin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TALICIA | RedHill Biopharma | N-213004 RX | 2019-11-01 | 1 products, RLD, RS |
Indications
FDA
EMA
Show 12 more
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
AMOXICILLIN / OMEPRAZOLE MAGNESIUM / RIFABUTIN, TALICIA, REDHILL | |||
| 2027-11-01 | GAIN | ||
| 2022-11-01 | NP | ||
ATC Codes
A: Alimentary tract and metabolism drugs
— A02: Drugs for acid related disorders
— A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
— A02BD: Combinations for eradication of helicobacter pylori
— A02BD16: Omeprazole, amoxicillin and rifabutin
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AB: Antibiotics, antitubercular
— J04AB04: Rifabutin
HCPCS
No data
Clinical
Clinical Trials
87 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 11 | 7 | 5 | 4 | 9 | 35 |
| Infections | D007239 | EFO_0000544 | — | 5 | 5 | 10 | 4 | 7 | 31 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 4 | 11 | 2 | 4 | 6 | 25 |
| Mycobacterium avium-intracellulare infection | D015270 | EFO_0007386 | — | 1 | 3 | 7 | 4 | 6 | 20 |
| Mycobacterium infections | D009164 | — | A31.9 | — | 4 | 8 | 1 | 7 | 18 |
| Communicable diseases | D003141 | — | — | 3 | 3 | 5 | 1 | 5 | 17 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | 3 | 3 | 2 | — | 6 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | 1 | 1 | 4 | 6 |
| Mycobacterium avium complex | D015269 | — | — | 1 | 1 | 1 | 2 | — | 5 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | 2 | 1 | 1 | 1 | 4 |
Show 9 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 4 | 2 | 1 | — | 2 | 9 |
| Mycoses | D009181 | — | B35-B49 | 1 | — | 1 | — | — | 2 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | 2 | — | — | 2 |
| Nontuberculous mycobacterium infections | D009165 | EFO_0007461 | A31.9 | — | — | 1 | — | 1 | 2 |
| Bronchiectasis | D001987 | HP_0002110 | J47 | — | — | 1 | — | — | 1 |
| Prosthesis-related infections | D016459 | EFO_1001406 | — | — | — | 1 | — | — | 1 |
| Latent tuberculosis | D055985 | — | Z22.7 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv | D006678 | — | — | 1 | 2 | — | — | — | 3 |
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | 1 | 1 | — | — | — | 2 |
| Pulmonary sarcoidosis | D017565 | DOID_13406 | D86.0 | 1 | 1 | — | — | — | 2 |
| Coronary disease | D003327 | — | — | — | 1 | — | — | — | 1 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | — | — | — | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | — | — | 1 |
| Chlamydophila infections | D023521 | EFO_1000863 | — | — | 1 | — | — | — | 1 |
| Chlamydial pneumonia | D061387 | — | J16.0 | — | 1 | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | — | — | — | 1 |
Show 6 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 8 | — | — | — | — | 8 |
| Bacterial infections | D001424 | — | A49 | 3 | — | — | — | — | 3 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 1 | — | — | — | — | 1 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Immunologic deficiency syndromes | D007153 | HP_0002721 | D84.9 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Rifabutin |
| INN | rifabutin |
| Description | Rifabutin (Rfb) is an antibiotic used to treat tuberculosis and prevent and treat Mycobacterium avium complex. It is typically only used in those who cannot tolerate rifampin such as people with HIV/AIDS on antiretrovirals. For active tuberculosis it is used with other antimycobacterial medications. For latent tuberculosis it may be used by itself when the exposure was with drug-resistant TB.
|
| Classification | Small molecule |
| Drug class | antibiotics (rifamycin derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(c3C2=O)C2=NC3(CCN(CC(C)C)CC3)NC2=C(NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C4=O |
Identifiers
| PDB | — |
| CAS-ID | 72559-06-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL444633 |
| ChEBI ID | 45367 |
| PubChem CID | 6323490 |
| DrugBank | DB00615 |
| UNII ID | 1W306TDA6S (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Rifabutin
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 7,197 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
2,026 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use