Retinol
Berocca Pn, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vitamin A, Vitaped (retinol) is a small molecule pharmaceutical. Retinol was first approved as Aquasol a on 1982-01-01. It is known to target nuclear receptor subfamily 2 group C member 2.
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Commercial
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 5% retinol | C200263 | 2024-10-16 |
| acne relief retinol treatment and moisturizer | OTC monograph final | 2022-02-10 |
| acne wipeout clinical acne system | OTC monograph final | 2020-10-15 |
| advanced retinol moisturizer | C200263 | 2024-10-20 |
| advanced retinol rejuvenating eye cream | C200263 | 2024-11-07 |
| anyi beauty retinol brightening anti aging face cream | C200263 | 2024-04-29 |
| aoao retinol anti-aging box set | C200263 | 2025-01-08 |
| aoao retinol anti-aging eye cream | C200263 | 2024-11-06 |
| aoao retinol anti-aging milk | C200263 | 2024-11-07 |
| aoao retinol anti-aging neck cream | C200263 | 2024-11-07 |
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11C: Vitamin a and d, incl. combinations of the two
— A11CA: Vitamin a, plain
— A11CA01: Retinol (vit a)
D: Dermatologicals
— D10: Anti-acne preparations
— D10A: Anti-acne preparations for topical use
— D10AD: Retinoids for topical use in acne
— D10AD02: Retinol
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AX: Other nasal preparations in atc
— R01AX02: Retinol
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA02: Retinol
HCPCS
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Clinical
Clinical Trials
3188 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 3 | 2 | 12 | 17 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | — | 1 | 1 | 4 | 6 |
| Energy metabolism | D004734 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | 1 | 1 | — | 5 | 7 |
| Venous thrombosis | D020246 | — | I82.40 | — | 1 | 1 | — | 4 | 6 |
| Thromboembolism | D013923 | — | — | — | — | 2 | — | — | 2 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | 1 | 2 |
| Transcatheter aortic valve replacement | D065467 | — | — | — | — | 1 | — | — | 1 |
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | — | 1 | — | — | 1 |
| Memory disorders | D008569 | — | — | — | — | 1 | — | — | 1 |
| Percutaneous coronary intervention | D062645 | — | — | — | — | 1 | — | — | 1 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 4 | 4 |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | — | — | 2 | 2 |
| Gastrointestinal hemorrhage | D006471 | — | K92.2 | — | — | — | — | 2 | 2 |
| Thrombosis | D013927 | — | — | — | — | — | — | 2 | 2 |
| Embolism | D004617 | — | — | — | — | — | — | 2 | 2 |
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Retinol |
| INN | retinol |
| Description | All-trans-retinol is a retinol in which all four exocyclic double bonds have E- (trans-) geometry. It has a role as a human metabolite, a mouse metabolite and a plant metabolite. It is a retinol and a vitamin A. |
| Classification | Small molecule |
| Drug class | retinol derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/CO)C(C)(C)CCC1 |
Identifiers
| PDB | — |
| CAS-ID | 11103-57-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL986 |
| ChEBI ID | 17336 |
| PubChem CID | 445354 |
| DrugBank | DB00162 |
| UNII ID | G2SH0XKK91 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NR2C2
NR2C2
Organism
Homo sapiens
Gene name
NR2C2
Gene synonyms
TAK1, TR4
NCBI Gene ID
Protein name
nuclear receptor subfamily 2 group C member 2
Protein synonyms
Nuclear hormone receptor TR4, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, orphan receptor TR4, testicular nuclear receptor 4, Testicular receptor 4
Uniprot ID
Mouse ortholog
Nr2c2 (22026)
nuclear receptor subfamily 2 group C member 2 (P55093)
Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 9,999 documents
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Safety
Black-box Warning
Black-box warning for: Prenatal plus multivitamin plus dha minicaps
Adverse Events
Top Adverse Reactions
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68,796 adverse events reported
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