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Drug ReportsRetinol
Retinol
Berocca Pn, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vitamin A, Vitaped (retinol) is a small molecule pharmaceutical. Retinol was first approved as Aquasol a on 1982-01-01. It is known to target nuclear receptor subfamily 2 group C member 2.
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Variants
Financial
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Safety
Events Timeline
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FDA approval date
EMA approval date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
5% retinolC2002632024-10-16
acne relief retinol treatment and moisturizerOTC monograph final2022-02-10
acne wipeout clinical acne systemOTC monograph final2020-10-15
advanced retinol moisturizerC2002632024-10-20
advanced retinol rejuvenating eye creamC2002632024-11-07
anyi beauty retinol brightening anti aging face creamC2002632024-04-29
aoao retinol anti-aging box setC2002632025-01-08
aoao retinol anti-aging eye creamC2002632024-11-06
aoao retinol anti-aging milkC2002632024-11-07
aoao retinol anti-aging neck creamC2002632024-11-07
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A11: Vitamins
A11C: Vitamin a and d, incl. combinations of the two
A11CA: Vitamin a, plain
A11CA01: Retinol (vit a)
D: Dermatologicals
D10: Anti-acne preparations
D10A: Anti-acne preparations for topical use
D10AD: Retinoids for topical use in acne
D10AD02: Retinol
R: Respiratory system drugs
R01: Nasal preparations
R01A: Decongestants and other nasal preparations for topical use
R01AX: Other nasal preparations in atc
R01AX02: Retinol
S: Sensory organ drugs
S01: Ophthalmologicals
S01X: Other ophthalmologicals in atc
S01XA: Other ophthalmologicals in atc
S01XA02: Retinol
HCPCS
No data
Clinical
Clinical Trials
3102 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E1311
Type 1 diabetes mellitusD003922EFO_0001359E1011
HypertriglyceridemiaD015228EFO_0004211111
HallucinationsD006212F06.0111
SchizophreniaD012559EFO_0000692F20111
Psychotic disordersD011618F20.81111
DelusionsD003702111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atrial fibrillationD001281EFO_0000275I48.022
Ocular hypertensionD009798EFO_1001069H40.011
Non-small-cell lung carcinomaD00228911
Lung injuryD055370S27.3011
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients33
NeuroblastomaD009447EFO_000062111
NeoplasmsD009369C8011
PharmacokineticsD01059911
ObesityD009765EFO_0001073E66.911
Type 2 diabetes mellitusD003924EFO_0001360E1111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Metabolic diseasesD008659EFO_0000589E88.911
Calcium metabolism disordersD002128EFO_0005769E83.511
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRetinol
INNretinol
Description
All-trans-retinol is a retinol in which all four exocyclic double bonds have E- (trans-) geometry. It has a role as a human metabolite, a mouse metabolite and a plant metabolite. It is a retinol and a vitamin A.
Classification
Small molecule
Drug classretinol derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC1=C(/C=C/C(C)=C/C=C/C(C)=C/CO)C(C)(C)CCC1
Identifiers
PDB
CAS-ID11103-57-4
RxCUI
ChEMBL IDCHEMBL986
ChEBI ID17336
PubChem CID445354
DrugBankDB00162
UNII IDG2SH0XKK91 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NR2C2
NR2C2
Organism
Homo sapiens
Gene name
NR2C2
Gene synonyms
TAK1, TR4
NCBI Gene ID
Protein name
nuclear receptor subfamily 2 group C member 2
Protein synonyms
Nuclear hormone receptor TR4, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, orphan receptor TR4, testicular nuclear receptor 4, Testicular receptor 4
Uniprot ID
Mouse ortholog
Nr2c2 (22026)
nuclear receptor subfamily 2 group C member 2 (P55093)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 44,468 documents
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Safety
Black-box Warning
Black-box warning for: Prenatal plus multivitamin plus dha minicaps
Adverse Events
Top Adverse Reactions
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68,882 adverse events reported
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