Retinol
Berocca Pn, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vitamin A, Vitaped (retinol) is a small molecule pharmaceutical. Retinol was first approved as Aquasol a on 1982-01-01. It is known to target nuclear receptor subfamily 2 group C member 2.
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Drug Products
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 5% retinol | C200263 | 2024-10-16 |
| acne relief retinol treatment and moisturizer | OTC monograph final | 2022-02-10 |
| acne wipeout clinical acne system | OTC monograph final | 2020-10-15 |
| advanced retinol moisturizer | C200263 | 2024-10-20 |
| advanced retinol rejuvenating eye cream | C200263 | 2024-11-07 |
| anyi beauty retinol brightening anti aging face cream | C200263 | 2024-04-29 |
| aoao retinol anti-aging box set | C200263 | 2025-01-08 |
| aoao retinol anti-aging eye cream | C200263 | 2024-11-06 |
| aoao retinol anti-aging milk | C200263 | 2024-11-07 |
| aoao retinol anti-aging neck cream | C200263 | 2024-11-07 |
Show 113 more
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ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11C: Vitamin a and d, incl. combinations of the two
— A11CA: Vitamin a, plain
— A11CA01: Retinol (vit a)
D: Dermatologicals
— D10: Anti-acne preparations
— D10A: Anti-acne preparations for topical use
— D10AD: Retinoids for topical use in acne
— D10AD02: Retinol
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AX: Other nasal preparations in atc
— R01AX02: Retinol
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA02: Retinol
HCPCS
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Clinical
Clinical Trials
3304 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 16 | 20 | 22 | 32 | 115 | 201 |
| Healthy volunteers/patients | — | — | — | 33 | 7 | 2 | 5 | 51 | 96 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | 9 | 15 | 28 | 18 | 24 | 92 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 6 | 11 | 4 | 4 | 54 | 77 |
| Neoplasms | D009369 | — | C80 | 28 | 9 | 11 | 7 | 20 | 72 |
| Anemia | D000740 | EFO_0004272 | D64.9 | 2 | 4 | 11 | 10 | 46 | 71 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 6 | 14 | 3 | 51 | 71 |
| Covid-19 | D000086382 | — | U07.1 | 3 | 19 | 17 | 7 | 24 | 67 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 7 | 16 | 10 | 4 | 35 | 67 |
| Vitamin a deficiency | D014802 | EFO_1001237 | E50 | 2 | 8 | 9 | 1 | 44 | 62 |
Show 326 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 10 | 16 | 9 | — | 13 | 47 |
| Non-small-cell lung carcinoma | D002289 | — | — | 11 | 29 | 10 | — | 4 | 47 |
| Uterine cervical neoplasms | D002583 | — | — | 3 | 5 | 3 | — | 37 | 47 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 14 | 14 | 3 | — | 6 | 35 |
| Prostatic neoplasms | D011471 | — | C61 | 8 | 16 | 9 | — | 4 | 33 |
| Asthma | D001249 | EFO_0000270 | J45 | 4 | 15 | 3 | — | 8 | 28 |
| Depression | D003863 | — | F33.9 | — | 7 | 2 | — | 18 | 27 |
| Hypercholesterolemia | D006937 | — | — | 1 | 4 | 12 | — | 8 | 25 |
| Cognitive dysfunction | D060825 | — | G31.84 | 2 | 8 | 2 | — | 13 | 24 |
| Myeloid leukemia | D007951 | — | C92 | 8 | 11 | 8 | — | — | 21 |
Show 266 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | 1 | 1 | — | — | 19 | 21 |
| Multiple myeloma | D009101 | — | C90.0 | 15 | 10 | — | — | — | 19 |
| Glioblastoma | D005909 | EFO_0000515 | — | 10 | 6 | — | — | 1 | 15 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 3 | 2 | — | — | 10 | 15 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 7 | 8 | — | — | 1 | 13 |
| Alopecia | D000505 | — | L64 | 2 | 1 | — | — | 10 | 13 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 8 | 7 | — | — | 1 | 12 |
| Melanoma | D008545 | — | — | 8 | 8 | — | — | 1 | 12 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | 5 | 1 | — | — | 5 | 11 |
| Dementia | D003704 | EFO_0003862 | F03 | 3 | 2 | — | — | 6 | 10 |
Show 260 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alopecia areata | D000506 | EFO_0004192 | L63 | 1 | — | — | — | 8 | 9 |
| Heart disease risk factors | D000082742 | — | — | 1 | — | — | — | 6 | 7 |
| Gestational diabetes | D016640 | — | O24.4 | 1 | — | — | — | 5 | 6 |
| Gingivitis | D005891 | — | K05.10 | 1 | — | — | — | 5 | 6 |
| Hot flashes | D019584 | — | — | 1 | — | — | — | 4 | 5 |
| Colitis | D003092 | EFO_0003872 | K52.9 | 2 | — | — | — | 2 | 4 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | 3 | 4 |
| Biological availability | D001682 | — | — | 1 | — | — | — | 3 | 4 |
| Carpal tunnel syndrome | D002349 | EFO_0004143 | G56.0 | 1 | — | — | — | 3 | 4 |
| Periodontal diseases | D010510 | — | K05.6 | 1 | — | — | — | 3 | 4 |
Show 70 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cognition | D003071 | EFO_0003925 | — | — | — | — | — | 10 | 10 |
| Diet therapy | D004035 | — | — | — | — | — | — | 8 | 8 |
| Healthy diet | D000072001 | — | — | — | — | — | — | 8 | 8 |
| Food diet and nutrition | D000066888 | — | — | — | — | — | — | 7 | 7 |
| Deglutition disorders | D003680 | — | R13.1 | — | — | — | — | 6 | 6 |
| Body weight changes | D001836 | — | — | — | — | — | — | 5 | 5 |
| Nutrition disorders | D009748 | EFO_0001069 | — | — | — | — | — | 5 | 5 |
| Behavior | D001519 | GO_0007610 | STY/T053 | — | — | — | — | 5 | 5 |
| Abdominal obesity | D056128 | — | — | — | — | — | — | 5 | 5 |
| Infertility | D007246 | EFO_0000545 | — | — | — | — | — | 5 | 5 |
Show 415 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Retinol |
| INN | retinol |
| Description | All-trans-retinol is a retinol in which all four exocyclic double bonds have E- (trans-) geometry. It has a role as a human metabolite, a mouse metabolite and a plant metabolite. It is a retinol and a vitamin A. |
| Classification | Small molecule |
| Drug class | retinol derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/CO)C(C)(C)CCC1 |
Identifiers
| PDB | — |
| CAS-ID | 11103-57-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL986 |
| ChEBI ID | 17336 |
| PubChem CID | 445354 |
| DrugBank | DB00162 |
| UNII ID | G2SH0XKK91 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NR2C2
NR2C2
Organism
Homo sapiens
Gene name
NR2C2
Gene synonyms
TAK1, TR4
NCBI Gene ID
Protein name
nuclear receptor subfamily 2 group C member 2
Protein synonyms
Nuclear hormone receptor TR4, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, orphan receptor TR4, testicular nuclear receptor 4, Testicular receptor 4
Uniprot ID
Mouse ortholog
Nr2c2 (22026)
nuclear receptor subfamily 2 group C member 2 (P55093)
Variants
No data
Financial
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Trends
PubMed Central
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Additional graphs summarizing 9,999 documents
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Safety
Black-box Warning
Black-box warning for: Prenatal plus multivitamin plus dha minicaps
Adverse Events
Top Adverse Reactions
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71,520 adverse events reported
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