Retaspimycin
Retaspimycin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target heat shock protein HSP 90-alpha.
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Commercial
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Clinical
Clinical Trials
53 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 8 | 1 | 1 | — | — | 10 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 1 | 2 | — | — | 4 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 1 | 2 | — | — | 4 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 20 | 2 | — | — | — | 21 |
| Leukemia | D007938 | — | C95 | 13 | 1 | — | — | — | 14 |
| Lymphoma | D008223 | — | C85.9 | 6 | 3 | — | — | — | 9 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 5 | 1 | — | — | — | 6 |
| Mantle-cell lymphoma | D020522 | — | — | 5 | 1 | — | — | — | 6 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 4 | 1 | — | — | — | 5 |
| Hodgkin disease | D006689 | — | C81 | 3 | 2 | — | — | — | 5 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 4 | — | — | — | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 4 | — | — | — | 5 |
| Prostatic neoplasms | D011471 | — | C61 | 2 | 2 | — | — | — | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 8 | — | — | — | — | 8 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 8 | — | — | — | — | 8 |
| Myeloid leukemia | D007951 | — | C92 | 6 | — | — | — | — | 6 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 5 | — | — | — | — | 5 |
| Follicular lymphoma | D008224 | — | C82 | 5 | — | — | — | — | 5 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 5 | — | — | — | — | 5 |
| B-cell lymphoma | D016393 | — | — | 5 | — | — | — | — | 5 |
| Lymphoid leukemia | D007945 | — | C91 | 4 | — | — | — | — | 4 |
| Mycoses | D009181 | — | B35-B49 | 4 | — | — | — | — | 4 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 4 | — | — | — | — | 4 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Retaspimycin |
| INN | retaspimycin |
| Description | Retaspimycin is an ansamycin that is tanespimycin in which the benzoquinone moiety has been reduced to the corresponding hydroquinone. A semi-synthetic analogue of geldanamycin, it is used (generally as the hydrochloride salt) in cancer treatment. It has a role as a Hsp90 inhibitor and an antineoplastic agent. It is a member of hydroquinones, an ansamycin, an organic heterobicyclic compound, a secondary amino compound, a semisynthetic derivative and a carbamate ester. It is functionally related to a geldanamycin. It is a conjugate base of a retaspimycin(1+). |
| Classification | Small molecule |
| Drug class | antibiotics (Streptomyces strain) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=CCNc1c(O)cc2c(O)c1C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)N2 |
Identifiers
| PDB | — |
| CAS-ID | 857402-23-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1184904 |
| ChEBI ID | 71975 |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | BZF2ZM0I5Z (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HSP90AA1
HSP90AA1
Organism
Homo sapiens
Gene name
HSP90AA1
Gene synonyms
HSP90A, HSPC1, HSPCA
NCBI Gene ID
Protein name
heat shock protein HSP 90-alpha
Protein synonyms
epididymis luminal secretory protein 52, epididymis secretory sperm binding protein Li 65p, Heat shock 86 kDa, heat shock 90kD protein 1, alpha, heat shock 90kD protein 1, alpha-like 4, heat shock 90kD protein, alpha-like 4, heat shock 90kDa protein 1, alpha, heat shock protein 90kDa alpha (cytosolic), class A member 1, heat shock protein 90kDa alpha family class A member 1, HSP 86, HSP86, LAP-2, Lipopolysaccharide-associated protein 2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38
Uniprot ID
Mouse ortholog
Hsp90aa1 (15519)
heat shock protein HSP 90-alpha (P07901)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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