Altabax, Altargo(retapamulin)
Altabax, Altargo (retapamulin) is a small molecule pharmaceutical. Retapamulin was first approved as Altabax on 2007-04-12. It is used to treat bacterial infections and impetigo in the USA. It has been approved in Europe to treat impetigo and staphylococcal skin infections.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| altabax | New Drug Application | 2010-09-02 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bacterial infections | — | D001424 | A49 |
| impetigo | EFO_1000714 | D007169 | L01 |
Agency Specific
FDA
EMA
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HCPCS
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Clinical
Clinical Trials
19 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial infections | D001424 | — | A49 | 1 | 1 | 3 | 1 | 2 | 8 |
| Infectious skin diseases | D012874 | — | — | 1 | — | 3 | 1 | 2 | 7 |
| Bacterial skin diseases | D017192 | — | — | 1 | — | 3 | 1 | 2 | 7 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | 1 | — | 3 | 1 | 2 | 7 |
| Impetigo | D007169 | EFO_1000714 | L01 | — | — | 3 | 1 | 1 | 5 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 3 | — | 3 |
| Eczema | D004485 | — | L30.9 | — | — | — | 2 | — | 2 |
| Communicable diseases | D003141 | — | — | — | — | — | 2 | — | 2 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | 2 | — | 2 |
| Methicillin-resistant staphylococcus aureus | D055624 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Retapamulin |
| INN | retapamulin |
| Description | Retapamulin is a carbotricyclic compound, a carboxylic ester and a cyclic ketone. |
| Classification | Small molecule |
| Drug class | antibacterials, pleuromulin derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C[C@]1(C)C[C@@H](OC(=O)CS[C@H]2C[C@@H]3CC[C@H](C2)N3C)[C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@H]32)[C@@H](C)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 224452-66-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1658 |
| ChEBI ID | — |
| PubChem CID | 6918462 |
| DrugBank | DB01256 |
| UNII ID | 4MG6O8991R (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Retapamulin
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 808 documents
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Safety
Black-box Warning
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Adverse Events
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711 adverse events reported
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