Resiniferatoxin
Resiniferatoxin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target voltage-gated potassium channel KCNC1, potassium voltage-gated channel subfamily A member 2, potassium voltage-gated channel subfamily A member 5, transient receptor potential cation channel subfamily V member 1, potassium voltage-gated channel subfamily A member 7, and potassium voltage-gated channel subfamily A member 1.
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Commercial
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Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 2 | 1 | 2 | — | — | 5 |
| Intractable pain | D010148 | — | — | 2 | 2 | 1 | — | — | 4 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 1 | 1 | 2 | — | — | 4 |
| Cancer pain | D000072716 | — | G89.3 | 1 | 1 | 1 | — | — | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Palliative care | D010166 | — | — | 2 | 1 | — | — | — | 2 |
| Facial pain | D005157 | — | R51.9 | — | 1 | — | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arthralgia | D018771 | HP_0002829 | M25.5 | 1 | — | — | — | — | 1 |
| Morton neuroma | D000070607 | — | G57.6 | 1 | — | — | — | — | 1 |
| Neuroma | D009463 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Resiniferatoxin |
| INN | resiniferatoxin |
| Description | Resiniferatoxin (RTX) is a naturally occurring chemical found in resin spurge (Euphorbia resinifera), a cactus-like plant commonly found in Morocco, and in Euphorbia poissonii found in northern Nigeria. It is a potent functional analog of capsaicin, the active ingredient in chili peppers.
|
| Classification | Small molecule |
| Drug class | fluoroquinolone derivatives, nonantibacterial indication (e.g., antineoplastic antibiotics) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C(C)[C@]12C[C@@H](C)[C@@]34O[C@](Cc5ccccc5)(O[C@@H]1[C@@H]3C=C(COC(=O)Cc1ccc(O)c(OC)c1)C[C@]1(O)C(=O)C(C)=C[C@H]14)O2 |
Identifiers
| PDB | — |
| CAS-ID | 57444-62-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL17976 |
| ChEBI ID | — |
| PubChem CID | 104826 |
| DrugBank | DB06515 |
| UNII ID | A5O6P1UL4I (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNC1
KCNC1
Organism
Homo sapiens
Gene name
KCNC1
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily C member 1
Protein synonyms
NGK2, potassium channel, voltage gated Shaw related subfamily C, member 1, voltage-gated potassium channel protein KV3.1, Voltage-gated potassium channel subunit Kv3.1, Voltage-gated potassium channel subunit Kv4
Uniprot ID
Mouse ortholog
Kcnc1 (16502)
potassium voltage-gated channel subfamily C member 1 (P15388)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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