Resiniferatoxin
Resiniferatoxin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target voltage-gated potassium channel KCNC1, potassium voltage-gated channel subfamily A member 2, potassium voltage-gated channel subfamily A member 5, transient receptor potential cation channel subfamily V member 1, potassium voltage-gated channel subfamily A member 7, and potassium voltage-gated channel subfamily A member 1.
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Clinical Trials
91 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pemphigus | D010392 | EFO_1000749 | L10 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 1 | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | 1 | — | — | — | 1 |
| Follicular lymphoma | D008224 | — | C82 | 1 | 1 | — | — | — | 1 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 1 | — | — | — | 1 |
| B-cell lymphoma | D016393 | — | — | 1 | 1 | — | — | — | 1 |
| Fibrosis | D005355 | — | — | 1 | 1 | — | — | — | 1 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | 1 | 1 | — | — | — | 1 |
| Pseudotumor cerebri | D011559 | EFO_1001132 | G93.2 | 1 | 1 | — | — | — | 1 |
| Sialadenitis | D012793 | EFO_1001179 | K11.2 | 1 | 1 | — | — | — | 1 |
| Autoimmune pancreatitis | D000081012 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Resiniferatoxin |
| INN | resiniferatoxin |
| Description | Resiniferatoxin (RTX) is a naturally occurring chemical found in resin spurge (Euphorbia resinifera), a cactus-like plant commonly found in Morocco, and in Euphorbia poissonii found in northern Nigeria. It is a potent functional analog of capsaicin, the active ingredient in chili peppers.
|
| Classification | Small molecule |
| Drug class | fluoroquinolone derivatives, nonantibacterial indication (e.g., antineoplastic antibiotics) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C(C)[C@]12C[C@@H](C)[C@@]34O[C@](Cc5ccccc5)(O[C@@H]1[C@@H]3C=C(COC(=O)Cc1ccc(O)c(OC)c1)C[C@]1(O)C(=O)C(C)=C[C@H]14)O2 |
Identifiers
| PDB | — |
| CAS-ID | 57444-62-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL17976 |
| ChEBI ID | — |
| PubChem CID | 104826 |
| DrugBank | DB06515 |
| UNII ID | A5O6P1UL4I (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
KCNC1
KCNC1
Organism
Homo sapiens
Gene name
KCNC1
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily C member 1
Protein synonyms
NGK2, potassium channel, voltage gated Shaw related subfamily C, member 1, voltage-gated potassium channel protein KV3.1, Voltage-gated potassium channel subunit Kv3.1, Voltage-gated potassium channel subunit Kv4
Uniprot ID
Mouse ortholog
Kcnc1 (16502)
potassium voltage-gated channel subfamily C member 1 (P15388)
Variants
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Safety
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10 adverse events reported
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