Lexiscan, Rapiscan(regadenoson)
Lexiscan, Rapiscan, Regadenoson (regadenoson) is a small molecule pharmaceutical. Regadenoson was first approved as Lexiscan on 2008-04-10. It has been approved in Europe to treat myocardial perfusion imaging. The pharmaceutical is active against adenosine receptor A2a. In addition, it is known to target adenosine receptor A3, adenosine receptor A1, and adenosine receptor A2b.
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Commercial
Trade Name
FDA
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Lexiscan, Regadenoson
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Regadenoson
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LEXISCAN | Astellas Pharma | N-022161 RX | 2008-04-10 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| lexiscan | New Drug Application | 2018-12-21 |
| lexiscan(r) (regadenoson) | New Drug Application | 2024-01-28 |
| regadenoson | ANDA | 2024-09-30 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
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HCPCS
Code | Description |
|---|---|
| J2785 | Injection, regadenoson, 0.1 mg |
Clinical
Clinical Trials
94 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | 6 | 8 | 8 | 10 | 25 | 56 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 3 | 6 | 6 | 6 | 12 | 32 |
| Coronary disease | D003327 | — | — | 1 | 4 | 6 | 5 | 8 | 24 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 2 | 1 | — | 1 | 1 | 5 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | — | 2 | 3 | 5 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | — | 1 | 2 | 4 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | 1 | 2 | 3 |
| Heart transplantation | D016027 | EFO_0010673 | — | — | — | — | 2 | 1 | 3 |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | — | — | 1 | 2 | 3 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | 1 | 2 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial perfusion imaging | D055414 | — | — | 1 | — | 1 | — | 3 | 5 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 2 | — | — | 2 | 5 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 1 | — | — | 1 | 2 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 1 | — | — | — | 1 |
| Stable angina | D060050 | — | I20.89 | — | 1 | — | — | — | 1 |
| Covid-19 | D000086382 | — | — | 1 | 1 | — | — | — | 1 |
| Pneumonia | D011014 | EFO_0003106 | — | 1 | 1 | — | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | — | — | — | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | — | — | — | 1 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | — | 1 | — | — | — | 1 |
| Retinal artery occlusion | D015356 | EFO_1001154 | H34.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Magnetic resonance imaging | D008279 | — | — | 1 | — | — | — | 1 | 2 |
| Lung transplantation | D016040 | — | — | 2 | — | — | — | — | 2 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | 1 | — | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | — | — | — | — | 1 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Hyperemia | D006940 | EFO_0003822 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
| Chest pain | D002637 | HP_0100749 | R07.9 | — | — | — | — | 2 | 2 |
| Hyperglycemia | D006943 | HP_0003074 | R73.9 | — | — | — | — | 1 | 1 |
| Percutaneous coronary intervention | D062645 | — | — | — | — | — | — | 1 | 1 |
| Coronary occlusion | D054059 | — | I21 | — | — | — | — | 1 | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
| Infarction | D007238 | EFO_0009463 | — | — | — | — | — | 1 | 1 |
| Microvascular angina | D017566 | — | — | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Regadenoson |
| INN | regadenoson |
| Description | Regadenoson is a purine nucleoside. |
| Classification | Small molecule |
| Drug class | adenosine A receptor agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNC(=O)c1cnn(-c2nc(N)c3ncn([C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)c3n2)c1.O |
Identifiers
| PDB | — |
| CAS-ID | 313348-27-5 |
| RxCUI | 1546015 |
| ChEMBL ID | CHEMBL3989695 |
| ChEBI ID | — |
| PubChem CID | 219024 |
| DrugBank | DB06213 |
| UNII ID | 7AXV542LZ4 (ChemIDplus, GSRS) |
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Safety
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4,905 adverse events reported
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