Rebamipide
Rebamipide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cholecystokinin receptor type A.
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Commercial
Therapeutic Areas
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FDA
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Agency Specific
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Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dry eye syndromes | D015352 | — | H04.12 | 1 | 4 | 6 | 4 | — | 15 |
| Keratoconjunctivitis sicca | D007638 | EFO_1000906 | — | — | 4 | 6 | 1 | — | 11 |
| Gastritis | D005756 | EFO_0000217 | K29.7 | 1 | 1 | 4 | 3 | 2 | 11 |
| Stomach ulcer | D013276 | — | K25 | — | 1 | 2 | 3 | 1 | 6 |
| Ulcer | D014456 | MPATH_579 | — | 1 | 3 | 2 | 1 | 1 | 6 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | 2 | 2 | 1 | — | 5 |
| Syndrome | D013577 | — | — | — | 1 | 1 | 2 | 1 | 5 |
| Sjogren's syndrome | D012859 | EFO_0000699 | M35.0 | — | 1 | — | 1 | 1 | 3 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | 1 | 1 | — | 2 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | 1 | 1 | — | — | 2 |
| Mucositis | D052016 | EFO_1001898 | — | — | 1 | 1 | — | — | 2 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | 1 | — | — | 1 |
| Duodenal ulcer | D004381 | EFO_0004607 | K26 | — | 1 | 1 | — | — | 1 |
| Peptic ulcer | D010437 | — | K27 | — | 1 | 1 | — | — | 1 |
| Atrophic gastritis | D005757 | EFO_1000826 | K29.4 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Keratoconjunctivitis | D007637 | — | H16.2 | — | 2 | — | — | — | 2 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | — | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 1 | — | — | — | 1 |
| Colitis | D003092 | EFO_0003872 | K52.9 | — | 1 | — | — | — | 1 |
| Xerostomia | D014987 | — | K11.7 | — | 1 | — | — | — | 1 |
| Behcet syndrome | D001528 | EFO_0003780 | M35.2 | 1 | 1 | — | — | — | 1 |
| Oral ulcer | D019226 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacogenomic testing | D000071185 | — | — | — | — | — | — | 1 | 1 |
| Therapeutic equivalency | D013810 | — | — | — | — | — | — | 1 | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | — | — | 1 | 1 |
| Adenoma | D000236 | — | — | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rebamipide |
| INN | rebamipide |
| Description | 2-[[(4-chlorophenyl)-oxomethyl]amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid is a secondary carboxamide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(NC(Cc1cc(=O)[nH]c2ccccc12)C(=O)O)c1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 90098-04-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1697771 |
| ChEBI ID | — |
| PubChem CID | 5042 |
| DrugBank | DB11656 |
| UNII ID | LR583V32ZR (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CCKAR
CCKAR
Organism
Homo sapiens
Gene name
CCKAR
Gene synonyms
CCKRA
NCBI Gene ID
Protein name
cholecystokinin receptor type A
Protein synonyms
CCK-A receptor, CCK-AR, CCK1-R, cholecystokinin type 1 receptor, cholecystokinin type-A receptor, Cholecystokinin-1 receptor
Uniprot ID
Mouse ortholog
Cckar (12425)
cholecystokinin receptor type A (Q9DBV6)
Variants
No data
Financial
Revenue by drug
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Rebamipide – Kubota Pharmaceutical
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Trends
PubMed Central
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Additional graphs summarizing 2,071 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,079 adverse events reported
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