Azilect(rasagiline)
Azilect, Rasagiline (rasagiline) is a small molecule pharmaceutical. Rasagiline was first approved as Azilect on 2005-02-21. It is used to treat parkinson disease in the USA. It has been approved in Europe to treat parkinson disease. The pharmaceutical is active against amine oxidase [flavin-containing] B.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
Azilect (generic drugs available since 2016-03-15)
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| parkinson disease | EFO_0002508 | D010300 | G20 |
Agency Specific
FDA
EMA
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HCPCS
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Clinical
Clinical Trials
63 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 4 | 3 | 17 | 17 | 9 | 48 |
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | — | — | 1 | — | 1 |
| Apathy | D057565 | HP_0000741 | — | — | — | — | 1 | — | 1 |
| Depression | D003863 | — | F33.9 | — | — | — | 1 | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Progressive supranuclear palsy | D013494 | EFO_0002512 | G23.1 | — | — | 1 | — | — | 1 |
| Restless legs syndrome | D012148 | EFO_0004270 | G25.81 | — | 1 | 1 | — | — | 1 |
| Rem sleep behavior disorder | D020187 | EFO_0007462 | G47.52 | — | 1 | 1 | — | — | 1 |
| Synucleinopathies | D000080874 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | — | 3 | — | — | — | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 2 | — | — | — | 2 |
| Brain injuries | D001930 | — | S06.9 | 1 | 1 | — | — | — | 1 |
| Multiple system atrophy | D019578 | — | — | — | 1 | — | — | — | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Serotonin syndrome | D020230 | EFO_1001842 | — | — | — | — | — | 1 | 1 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | — | — | 1 | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rasagiline |
| INN | rasagiline |
| Description | Rasagiline is an indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and a neuroprotective agent. It is a secondary amine, a member of indanes and a terminal acetylenic compound. |
| Classification | Small molecule |
| Drug class | Monoamine oxidase (MAO) inhibitors, type B |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C#CCN[C@@H]1CCc2ccccc21 |
Identifiers
| PDB | — |
| CAS-ID | 136236-51-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL887 |
| ChEBI ID | 63620 |
| PubChem CID | 3052776 |
| DrugBank | DB01367 |
| UNII ID | 003N66TS6T (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,508 adverse events reported
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