Ramipril
Altace, Ramipril (ramipril) is a small molecule pharmaceutical. Ramipril was first approved as Altace on 1991-01-28. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Altace (generic drugs available since 2005-10-24)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ramipril
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ALTACE | King Pharmaceuticals | N-019901 RX | 1991-01-28 | 4 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| altace | New Drug Application | 2023-11-28 |
| delixir g toothpaste | unapproved drug other | 2023-05-17 |
| ramipril | ANDA | 2024-07-31 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| heart failure | HP_0001635 | D006333 | I50 |
| diabetic nephropathies | EFO_0000401 | D003928 | — |
| hypertension | EFO_0000537 | D006973 | I10 |
| left ventricular dysfunction | — | D018487 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09A: Ace inhibitors, plain
— C09AA: Ace inhibitors, plain
— C09AA05: Ramipril
— C09B: Ace inhibitors, combinations
— C09BA: Ace inhibitors and diuretics
— C09BA05: Ramipril and diuretics
— C09BB: Ace inhibitors and calcium channel blockers
— C09BB05: Ramipril and felodipine
— C09BB07: Ramipril and amlodipine
— C09BX: Ace inhibitors, other combinations in atc
— C09BX03: Ramipril, amlodipine and hydrochlorothiazide
— C09BX05: Ramipril and bisoprolol
— C10: Lipid modifying agents
— C10B: Lipid modifying agents, combinations
— C10BX: Lipid modifying agents in combination with other drugs
— C10BX04: Simvastatin, acetylsalicylic acid and ramipril
— C10BX06: Atorvastatin, acetylsalicylic acid and ramipril
— C10BX17: Rosuvastatin and ramipril
— C10BX18: Atorvastatin, amlodipine and ramipril
HCPCS
No data
Clinical
Clinical Trials
194 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 3 | 7 | 19 | 28 | 9 | 65 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 4 | 5 | 8 | 4 | 20 |
| Healthy volunteers/patients | — | — | — | 17 | — | — | 1 | 2 | 20 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | 2 | 8 | 4 | 3 | 17 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | 4 | 5 | 3 | 14 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | 3 | 5 | 2 | 11 |
| Heart failure | D006333 | HP_0001635 | I50 | — | 1 | 2 | 3 | 5 | 11 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 6 | 3 | 1 | 10 |
| Essential hypertension | D000075222 | — | I10 | — | — | 4 | 5 | — | 9 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | 4 | 3 | — | 8 |
Show 46 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | 3 | — | 1 | 4 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 1 | 2 | — | 1 | 3 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | 2 | 1 | — | — | 3 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | 3 | — | — | 3 |
| Hereditary nephritis | D009394 | EFO_0004128 | Q87.81 | — | — | 1 | — | 2 | 3 |
| Fibrosis | D005355 | — | — | — | — | 2 | — | — | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | — | 2 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | — | 1 | 1 | — | — | 2 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | — | 2 | 1 | — | — | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | 1 | — | — | 2 |
Show 27 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pheochromocytoma | D010673 | — | — | — | 1 | — | — | — | 1 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | 1 | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | 1 | — | — | — | 1 |
| Chemoradiotherapy | D059248 | — | — | — | 1 | — | — | — | 1 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 1 | — | — | — | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | — | — | 1 |
| Vasculitis | D014657 | HP_0002633 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 2 | — | — | — | 1 | 3 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | 1 | — | — | — | 1 | 2 |
| Stable angina | D060050 | — | I20.89 | 1 | — | — | — | 1 | 2 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Crush injuries | D000071576 | — | T14.8 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 2 | 2 |
| Oligospermia | D009845 | — | N46.1 | — | — | — | — | 1 | 1 |
| Teratozoospermia | D000072660 | HP_0012205 | — | — | — | — | — | 1 | 1 |
| Asthenozoospermia | D053627 | — | — | — | — | — | — | 1 | 1 |
| Male infertility | D007248 | EFO_0004248 | N46 | — | — | — | — | 1 | 1 |
| Infertility | D007246 | HP_0000789 | — | — | — | — | — | 1 | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 1 | 1 |
| Hematuria | D006417 | HP_0000790 | R31 | — | — | — | — | 1 | 1 |
| Wasting syndrome | D019282 | — | — | — | — | — | — | 1 | 1 |
| Cachexia | D002100 | HP_0004326 | R64 | — | — | — | — | 1 | 1 |
Show 7 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ramipril |
| INN | ramipril |
| Description | Ramipril is a dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug, a cardioprotective agent, a matrix metalloproteinase inhibitor and a bradykinin receptor B2 agonist. It is a dicarboxylic acid monoester, an azabicycloalkane, a cyclopentapyrrole, a dipeptide and an ethyl ester. |
| Classification | Small molecule |
| Drug class | antihypertensives (ACE inhibitors) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCC[C@@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 87333-19-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1168 |
| ChEBI ID | 8774 |
| PubChem CID | 5362129 |
| DrugBank | DB00178 |
| UNII ID | L35JN3I7SJ (ChemIDplus, GSRS) |
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
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Variants
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Financial
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Estimated US medical usage
Ramipril
Total medical expenditures per year (USD, in millions)
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 13,131 documents
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Safety
Black-box Warning
Black-box warning for: Altace
Adverse Events
Top Adverse Reactions
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41,371 adverse events reported
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