Ramelteon
Ramelteon, Rozerem (ramelteon) is a small molecule pharmaceutical. Ramelteon was first approved as Rozerem on 2005-07-22. It is used to treat sleep initiation and maintenance disorders in the USA. The pharmaceutical is active against melatonin receptor type 1A and melatonin receptor type 1B.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Rozerem (generic drugs available since 2013-07-26)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| sleep initiation and maintenance disorders | — | D007319 | F51.01 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
77 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 2 | 4 | 17 | 13 | 4 | 40 |
| Delirium | D003693 | — | R41.0 | — | 1 | — | 5 | 1 | 7 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | 4 | 1 | — | 5 |
| Sleep wake disorders | D012893 | — | G47 | — | 2 | — | 1 | 1 | 4 |
| Parasomnias | D020447 | — | G47.5 | — | 1 | 1 | 1 | 1 | 4 |
| Depression | D003863 | — | F33.9 | — | — | 2 | 1 | — | 3 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | 2 | 1 | — | 3 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | 2 | — | 2 |
| Sleep deprivation | D012892 | — | F51.12 | — | — | — | 1 | 1 | 2 |
| Rem sleep behavior disorder | D020187 | EFO_0007462 | G47.52 | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | 1 | 1 | — | 1 | 3 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | — | 1 | 1 | — | 1 | 3 |
| Apnea | D001049 | HP_0002104 | R06.81 | — | 1 | 1 | — | — | 2 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | 1 | — | — | 1 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | — | 1 | — | — | — | 1 |
| Lung injury | D055370 | — | S27.30 | — | 1 | — | — | — | 1 |
| Tobacco use disorder | D014029 | — | F17 | — | 1 | — | — | — | 1 |
| Delayed emergence from anesthesia | D055191 | — | — | — | 1 | — | — | — | 1 |
| Emergence delirium | D000071257 | — | — | — | 1 | — | — | — | 1 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 1 | — | — | — | 1 |
| Cognition disorders | D003072 | — | — | — | 1 | — | — | — | 1 |
| Neurocognitive disorders | D019965 | — | F09 | — | 1 | — | — | — | 1 |
| Migraine without aura | D020326 | EFO_0005296 | G43.0 | — | 1 | — | — | — | 1 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Marijuana abuse | D002189 | EFO_0007191 | F12 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinsonian disorders | D020734 | HP_0001300 | G20.C | — | — | — | — | 1 | 1 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 1 | 1 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 1 | 1 |
| Panic disorder | D016584 | EFO_0004262 | F41.0 | — | — | — | — | 1 | 1 |
| Lewy body disease | D020961 | EFO_0006792 | G31.83 | — | — | — | — | 1 | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | — | — | 1 | 1 |
| Huntington disease | D006816 | Orphanet_399 | G10 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ramelteon |
| INN | ramelteon |
| Description | N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e]benzofuran-8-yl]ethyl]propanamide is a member of indanes. |
| Classification | Small molecule |
| Drug class | selective melatonin receptor agonist |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC(=O)NCC[C@@H]1CCc2ccc3c(c21)CCO3 |
Identifiers
| PDB | — |
| CAS-ID | 196597-26-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1218 |
| ChEBI ID | — |
| PubChem CID | 208902 |
| DrugBank | DB00980 |
| UNII ID | 901AS54I69 (ChemIDplus, GSRS) |
Target
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Estimated US medical usage
Ramelteon
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 1,718 documents
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Safety
Black-box Warning
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Adverse Events
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3,678 adverse events reported
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