Rabeprazole
Aciphex, Rabeprazole (rabeprazole) is a small molecule pharmaceutical. Rabeprazole was first approved as Aciphex on 1999-08-19. It is used to treat duodenal ulcer, gastroesophageal reflux, heartburn, helicobacter infections, and zollinger-ellison syndrome in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Aciphex, Rabeprazole (discontinued: Aciphex, Rabeprazole)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Rabeprazole sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ACIPHEX | Waylis Therapeutics | N-020973 RX | 1999-08-19 | 1 products, RLD, RS |
Show 2 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aciphex | New Drug Application | 2025-01-24 |
| rabeprazole sodium | ANDA | 2025-05-13 |
| rabeprazole sodium delayed-release | NDA authorized generic | 2020-12-29 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A02: Drugs for acid related disorders
— A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
— A02BC: Proton pump inhibitors for peptic ulcer and gord
— A02BC04: Rabeprazole
— A02BC54: Rabeprazole, combinations
— A02BD: Combinations for eradication of helicobacter pylori
— A02BD12: Rabeprazole, amoxicillin and clarithromycin
— A02BD13: Rabeprazole, amoxicillin and metronidazole
HCPCS
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Clinical
Clinical Trials
269 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 8 | 5 | — | — | — | 9 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
| Female genital neoplasms | D005833 | — | — | 1 | 1 | — | — | — | 1 |
| Urologic neoplasms | D014571 | — | C64-C68 | 1 | 1 | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 1 | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | 1 | — | — | — | 1 |
| Esophageal motility disorders | D015154 | — | K22.4 | — | 1 | — | — | — | 1 |
| Diffuse esophageal spasm | D015155 | EFO_1001785 | K22.4 | — | 1 | — | — | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug interactions | D004347 | — | — | 4 | — | — | — | — | 4 |
| Pharmacokinetics | D010599 | — | — | 3 | — | — | — | — | 3 |
| Lymphoma | D008223 | — | C85.9 | 2 | — | — | — | 1 | 3 |
| Covid-19 | D000086382 | — | U07.1 | 1 | — | — | — | 1 | 2 |
| Biological availability | D001682 | — | — | 2 | — | — | — | — | 2 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | 2 | — | — | — | — | 2 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | 2 | — | — | — | — | 2 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | — | — | — | — | 1 |
| Fatty liver | D005234 | EFO_0003934 | — | 1 | — | — | — | — | 1 |
Show 10 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 1 | 1 |
| Community-acquired pneumonia | D000098968 | — | — | — | — | — | — | 1 | 1 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | — | 1 | 1 |
| Calcium metabolism disorders | D002128 | EFO_0005769 | E83.5 | — | — | — | — | 1 | 1 |
| Sudden death cardiac | D016757 | EFO_0004278 | — | — | — | — | — | 1 | 1 |
| Death | D003643 | PATO_0001422 | — | — | — | — | — | 1 | 1 |
| Sudden death | D003645 | — | — | — | — | — | — | 1 | 1 |
| Signs and symptoms | D012816 | EFO_0003765 | R68 | — | — | — | — | 1 | 1 |
| Pharyngeal diseases | D010608 | — | — | — | — | — | — | 1 | 1 |
| Patient compliance | D010349 | — | — | — | — | — | — | 1 | 1 |
Show 12 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rabeprazole |
| INN | rabeprazole |
| Description | Rabeprazole is a member of benzimidazoles, a sulfoxide and a member of pyridines. It has a role as an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor and an anti-ulcer drug. It is a conjugate acid of a rabeprazole(1-). |
| Classification | Small molecule |
| Drug class | antiulcer agents (benzimidazole derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C |
Identifiers
| PDB | — |
| CAS-ID | 117976-89-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1219 |
| ChEBI ID | 8768 |
| PubChem CID | 5029 |
| DrugBank | DB01129 |
| UNII ID | 32828355LL (ChemIDplus, GSRS) |
Target
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Financial
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Estimated US medical usage
Rabeprazole
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Trends
PubMed Central
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Additional graphs summarizing 4,673 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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14,028 adverse events reported
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