REVAMILAST
Revamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 3',5'-cyclic-AMP phosphodiesterase 4A.
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FDA approval date
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Commercial
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Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | 1 | — | — | — | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | REVAMILAST |
| INN | revamilast |
| Description | Revamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 3',5'-cyclic-AMP phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A. |
| Classification | Small molecule |
| Drug class | antiasthmatics/antiallergics (not acting primarily as antihistamines): type IV phosphodiesterase |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(Nc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c2oc3ccncc3c12 |
Identifiers
| PDB | — |
| CAS-ID | 893555-90-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297527 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 30LE65637T (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDE4A
PDE4A
Organism
Homo sapiens
Gene name
PDE4A
Gene synonyms
DPDE2
NCBI Gene ID
Protein name
3',5'-cyclic-AMP phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Protein synonyms
cAMP-specific phosphodiesterase 4A, DPDE2, PDE46, phosphodiesterase 4A, cAMP-specific (dunce, phosphodiesterase E2 dunce homolog, Drosophila, phosphodiesterase isozyme 4
Uniprot ID
Mouse ortholog
Pde4a (18577)
3',5'-cyclic-AMP phosphodiesterase 4A (Q9QXI8)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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