REFAMETINIB
Refametinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against dual specificity mitogen-activated protein kinase kinase 1 and dual specificity mitogen-activated protein kinase kinase 2.
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Events Timeline
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Commercial
No data
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | 1 | — | — | — | 6 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | 3 | — | — | — | 3 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 3 | — | — | — | 3 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | — | 2 |
| Biliary tract neoplasms | D001661 | — | C24.9 | — | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | REFAMETINIB |
| INN | refametinib |
| Description | Refametinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against dual specificity mitogen-activated protein kinase kinase 1 and dual specificity mitogen-activated protein kinase kinase 2. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors: tyrosine kinase inhibitors; MEK (MAPK kinase) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1NS(=O)(=O)C1(C[C@H](O)CO)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 923032-36-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1236682 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB06309 |
| UNII ID | JPX07AFM0N (ChemIDplus, GSRS) |
Target
Agency Approved
MAP2K1
MAP2K1
MAP2K2
MAP2K2
Organism
Homo sapiens
Gene name
MAP2K1
Gene synonyms
MEK1, PRKMK1
NCBI Gene ID
Protein name
dual specificity mitogen-activated protein kinase kinase 1
Protein synonyms
ERK activator kinase 1, MAPK/ERK kinase 1, MAPKK 1, MEK 1, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Uniprot ID
Mouse ortholog
Map2k1 (26395)
dual specificity mitogen-activated protein kinase kinase 1 (P31938)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 752 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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30 adverse events reported
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