RASEGLURANT
Raseglurant is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | 2 | — | — | — | 2 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | RASEGLURANT |
| INN | raseglurant |
| Description | Raseglurant (INN) (code name ADX-10059) is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP which was under development by Addex Therapeutics for the treatment of migraine, gastroesophageal reflux disease, and dental anxiety. It reached phase II clinical trials for all of the aforementioned indications before being discontinued due to the observation of possible predictive signs of hepatotoxicity in patients with long-term use.
|
| Classification | Small molecule |
| Drug class | metabotropic glutamate receptor antagonists, negative allosteric modulators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(C)c(N)c(C#Cc2cccc(F)c2)n1 |
Identifiers
| PDB | — |
| CAS-ID | 757950-09-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545036 |
| ChEBI ID | — |
| PubChem CID | 10331863 |
| DrugBank | — |
| UNII ID | 66UCJ8Z8L1 (ChemIDplus, GSRS) |
Target
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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