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Drug ReportsRADAFAXINE
RADAFAXINE
Radafaxine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863F33.933
Major depressive disorderD003865EFO_0003761F2233
Depressive disorderD003866EFO_1002014F32.A33
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRADAFAXINE
INNradafaxine
Description
Radafaxine (developmental code GW-353,162; also known as (2S,3S)-hydroxybupropion or (S,S)-hydroxybupropion) is a norepinephrine–dopamine reuptake inhibitor (NDRI) which was under development by GlaxoSmithKline in the 2000s for a variety of different indications but was never marketed. These uses included treatment of restless legs syndrome, major depressive disorder, bipolar disorder, neuropathic pain, fibromyalgia, and obesity. Regulatory filing was planned for 2007, but development was discontinued in 2006 due to "poor test results".
Classification
Small molecule
Drug classantianxiety, antidepressant inhibitor of norepinephrine and dopamine re-uptake
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Structure (InChI/SMILES or Protein Sequence)
C[C@@H]1NC(C)(C)CO[C@@]1(O)c1cccc(Cl)c1
Identifiers
PDB
CAS-ID192374-14-4
RxCUI
ChEMBL IDCHEMBL1172928
ChEBI ID
PubChem CID9795056
DrugBank
UNII IDQ47741214K (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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