RABUSERTIB
Rabusertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against serine/threonine-protein kinase Chk1.
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2Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
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Start date
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Commercial
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 1 | 1 | — | — | — | 1 |
| Mesothelioma | D008654 | — | C45 | 1 | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 1 | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | RABUSERTIB |
| INN | rabusertib |
| Description | 1-[5-bromo-4-methyl-2-[[(2S)-2-morpholinyl]methoxy]phenyl]-3-(5-methyl-2-pyrazinyl)urea is a member of ureas. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cnc(NC(=O)Nc2cc(Br)c(C)cc2OC[C@@H]2CNCCO2)cn1 |
Identifiers
| PDB | — |
| CAS-ID | 911222-45-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3039517 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 3S9L1NU6U7 (ChemIDplus, GSRS) |
Target
Agency Approved
CHEK1
CHEK1
Organism
Homo sapiens
Gene name
CHEK1
Gene synonyms
CHK1
NCBI Gene ID
Protein name
serine/threonine-protein kinase Chk1
Protein synonyms
Cell cycle checkpoint kinase, Checkpoint kinase-1, Checkpoint, S. pombe, homolog of, 1, CHK1 checkpoint homolog, Chk1-S
Uniprot ID
Mouse ortholog
Chek1 (12649)
serine/threonine-protein kinase Chk1 (Q9D0N2)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 435 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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16 adverse events reported
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