Quinine
Qualaquin, Quinine (quinine) is a small molecule pharmaceutical. Quinine was first approved as Qualaquin on 2005-08-12. It is used to treat babesiosis, falciparum malaria, malaria, and muscle cramp in the USA. It is known to target equilibrative nucleoside transporter 4, potassium voltage-gated channel subfamily B member 2, and potassium channel subfamily K member 18.
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Commercial
Trade Name
FDA
EMA
Quinine (discontinued: Qualaquin, Quinine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Quinine sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| QUALAQUIN | Sun Pharmaceutical Industries | N-021799 DISCN | 2005-08-12 | 1 products, RLD |
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Brand Name | Status | Last Update |
|---|---|---|
| qualaquin | New Drug Application | 2013-04-23 |
| quinine sulfate | ANDA | 2024-12-09 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M09: Other drugs for disorders of the musculo-skeletal system in atc
— M09A: Other drugs for disorders of the musculo-skeletal system in atc
— M09AA: Quinine and derivatives for disorders of the musculo-skeletal system
— M09AA72: Quinine, combinations with psycholeptics
P: Antiparasitic products, insecticides and repellents
— P01: Antiprotozoals
— P01B: Antimalarials
— P01BC: Methanolquinolines, antimalarial
— P01BC01: Quinine
HCPCS
No data
Clinical
No data
Drug
General
| Drug common name | Quinine |
| INN | — |
| Description | Quinine is a cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy. It has a role as an antimalarial, a muscle relaxant and a non-narcotic analgesic. It is a conjugate base of a quinine(1+). It derives from a hydride of an (8S)-cinchonan. |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (salicylic acid derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12 |
Target
Agency Approved
No data
Alternate
SLC29A4
SLC29A4
KCNB2
KCNB2
KCNK18
KCNK18
Organism
Homo sapiens
Gene name
SLC29A4
Gene synonyms
ENT4, PMAT
NCBI Gene ID
Protein name
equilibrative nucleoside transporter 4
Protein synonyms
Plasma membrane monoamine transporter, PMAT, solute carrier family 29 (equilibrative nucleoside transporter), member 4, solute carrier family 29 (nucleoside transporters), member 4, Solute carrier family 29 member 4
Uniprot ID
Mouse ortholog
Slc29a4 (243328)
equilibrative nucleoside transporter 4 (Q8R139)
Variants
No data
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Estimated US medical usage
Quinine
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Tabular view
Trends
No data
Safety
Black-box Warning
Black-box warning for: Qualaquin, Quinine sulfate
Adverse Events
0 adverse events reported
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