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Drug ReportsQuinidine
Quinidex, Nuedexta(quinidine)
Cardioquin, Nuedexta, Quinidine (quinidine) is a small molecule pharmaceutical. Quinidine was first approved as Quinaglute on 1982-01-01. It is used to treat atrial fibrillation, atrial flutter, and cardiac arrhythmias in the USA. It has been approved in Europe to treat neurobehavioral manifestations. It is known to target voltage-gated delayed rectifier potassium channel KCNH5; potassium voltage-gated channel subfamily H member 5, potassium channel subfamily K member 5, voltage-gated delayed rectifier potassium channel KCNH1; potassium voltage-gated channel subfamily H member 1, potassium channel subfamily T member 1, potassium channel subfamily T member 2, potassium channel subfamily K member 18, potassium channel subfamily K member 6, equilibrative nucleoside transporter 4, potassium channel subfamily K member 16, potassium channel subfamily K member 10, potassium voltage-gated channel subfamily A member 5, potassium voltage-gated channel subfamily A member 4, sodium channel protein type 5 subunit alpha, potassium voltage-gated channel subfamily A member 7, A-type voltage-gated potassium channel KCND2, and potassium channel subfamily U member 1.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
behavior and behavior mechanismsD001520
Trade Name
FDA
EMA
Quinidine (discontinued: Cin-quin, Duraquin, Quinact, Quinaglute, Quinalan, Quinatime, Quinidex, Quinidine, Quinora)
Combinations
Dextromethorphan quinidine, Nuedexta
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dextromethorphan hydrobromide
+
Quinidine sulfate
Tradename
Company
Number
Date
Products
NUEDEXTAAvanir PharmaceuticalsN-021879 RX2010-10-29
1 products, RLD, RS
Quinidine sulfate
Tradename
Company
Number
Date
Products
QUINIDEXWyethN-012796 DISCN1982-01-01
1 products
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Quinidine gluconate
Tradename
Company
Number
Date
Products
QUINAGLUTEBayerN-016647 DISCN1982-01-01
1 products, RLD
QUINIDINE GLUCONATEEli LillyN-007529 DISCN1989-02-10
1 products, RLD
DURAQUINWarner ChilcottN-017917 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
dextromethorphan hydrobromide and quinidine sulfateANDA2025-02-03
nuedextaNew Drug Application2025-10-21
quinidine gluconateANDA2024-08-27
quinidine sulfateANDA2023-11-08
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
atrial fibrillationEFO_0000275D001281I48.0
atrial flutterEFO_0003911D001282—
cardiac arrhythmiasEFO_0004269D001145I49.9
cough—D003371R05
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Dextromethorphan Hydrobromide / Quinidine Sulfate, Nuedexta, Avanir Pharms
76592822026-08-13U-1093
82274842023-07-17U-1093
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01B: Antiarrhythmics, class i and iii
— C01BA: Antiarrhythmics, class ia
— C01BA01: Quinidine
— C01BA51: Quinidine, combinations excl. psycholeptics
— C01BA71: Quinidine, combinations with psycholeptics
HCPCS
No data
Clinical
Clinical Trials
68 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Major depressive disorderD003865EFO_0003761F221————1
Depressive disorderD003866EFO_1002014F32.A1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameQuinidine
INN—
Description
Quinidine is a cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. It has a role as an alpha-adrenergic antagonist, an antimalarial, an anti-arrhythmia drug, a sodium channel blocker, a muscarinic antagonist, a potassium channel blocker, a P450 inhibitor, an EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor, an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor and a drug allergen. It derives from a hydride of a cinchonan.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12
Identifiers
PDB—
CAS-ID56-54-2
RxCUI—
ChEMBL IDCHEMBL1294
ChEBI ID28593
PubChem CID441074
DrugBankDB00908
UNII ID—
Target
Agency Approved
No data
Alternate
KCNT2
KCNT2
KCND2
KCND2
Organism
Homo sapiens
Gene name
KCNT2
Gene synonyms
SLICK
NCBI Gene ID
343450
Protein name
potassium channel subfamily T member 2
Protein synonyms
potassium channel, subfamily T, member 2, Sequence like an intermediate conductance potassium channel subunit, Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1, sodium-and chloride-activated ATP-sensitive potassium channel (SLICK)
Uniprot ID
Q6UVM3
Mouse ortholog
Kcnt2 (240776)
potassium channel subfamily T member 2 (D3YTU6)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Quinidine
+
Dextromethorphan
Total medical expenditures per year (USD, in millions)
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Quinidine
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 14,505 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,759 adverse events reported
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