Quinapril
Quinapril (quinapril) is a small molecule pharmaceutical. Quinapril was first approved as Accupril on 1991-11-19. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. It is known to target angiotensin-converting enzyme.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Quinapril (discontinued: Accupril, Quinapril)
CombinationsQuinapril hydrochlorothiazide (discontinued: Accuretic, Quinapril hydrochlorothiazide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| accupril | New Drug Application | 2023-09-15 |
| accuretic | New Drug Application | 2023-09-18 |
| quinapril | ANDA | 2024-05-30 |
| quinapril and hydrochlorothiazide 20/12.5 quinapril and hydrochlorothiazide 10/12.5 quinapril and hydrochlorothiazide 20/25 | ANDA | 2022-01-07 |
| quinapril and hydrochlorothiazide | ANDA | 2023-12-11 |
| quinapril and hydrochlorothiazide 10/12.5 | ANDA | 2018-12-20 |
| quinapril hcl and hydrochlorothiazide | ANDA | 2024-01-30 |
| quinapril hydrochloride | NDA authorized generic | 2014-06-13 |
| quinapril hydrochloride and hydrochlorothiazide | ANDA | 2016-01-08 |
| quinapril hydrochloride/hydrochlorothiazide | ANDA | 2024-04-28 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
31 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 9 | 6 | 15 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | 1 | 3 | 1 | 5 |
| Covid-19 | D000086382 | — | — | — | — | — | 1 | 1 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | 2 | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 2 | — | 2 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | 2 | — | 2 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | 1 | 1 | 2 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | — | — | 2 | — | 2 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | — | — | 1 | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | 2 | 6 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | — | — | — | 1 | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 1 | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | — | — | 1 | 1 |
| Ovarian epithelial carcinoma | D000077216 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Quinapril |
| INN | quinapril |
| Description | Quinapril is a member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a member of isoquinolines, a dicarboxylic acid monoester, an ethyl ester and a tertiary carboxamide. |
| Classification | Small molecule |
| Drug class | antihypertensives (ACE inhibitors) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 85441-61-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1592 |
| ChEBI ID | 8713 |
| PubChem CID | 54892 |
| DrugBank | DB00881 |
| UNII ID | RJ84Y44811 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Quinapril
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Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
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Quinapril
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Trends
PubMed Central
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Additional graphs summarizing 1,977 documents
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Safety
Black-box Warning
Black-box warning for: Accupril, Accuretic, Quinapril, Quinapril and hydrochlorothiazide 20/12.5 quinapril and hydrochlorothiazide 10/12.5 quinapril and hydrochlorothiazide 20/25, Quinapril and hydrochlorothiazide, Quinapril and hydrochlorothiazide 10/12.5, Quinapril hcl and hydrochlorothiazide, Quinapril hydrochloride, Quinapril hydrochloride and hydrochlorothiazide, Quinapril hydrochloride/hydrochlorothiazide
Adverse Events
Top Adverse Reactions
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4,331 adverse events reported
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