Quetiapine
Quetiapine, Seroquel (quetiapine) is a small molecule pharmaceutical. Quetiapine was first approved as Seroquel on 1997-09-26. It is used to treat autistic disorder, bipolar disorder, major depressive disorder, psychotic disorders, and schizophrenia amongst others in the USA. The pharmaceutical is active against D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A. In addition, it is known to target 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine receptor 1A, histamine H1 receptor, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 1F, and sodium-dependent noradrenaline transporter.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Quetiapine, Seroquel (discontinued: Quetiapine, Seroquel)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Quetiapine fumarate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SEROQUEL | CHEPLAPHARM Arzneimittel | N-020639 RX | 1997-09-26 | 6 products, RLD |
| SEROQUEL XR | CHEPLAPHARM Arzneimittel | N-022047 RX | 2007-05-17 | 5 products, RLD |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| quetiapine | ANDA | 2025-09-25 |
| quetiapine fumarate | ANDA | 2025-09-22 |
| quetiapine fumarate er | ANDA | 2025-09-26 |
| seroquel | New Drug Application | 2025-06-13 |
| seroquel xr | 2008-01-17 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
483 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | 1 | 1 | 3 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | 1 | 1 | — | 2 |
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 1 | 1 |
| Syndrome | D013577 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Quetiapine |
| INN | quetiapine |
| Description | Quetiapine is a dibenzothiazepine, a N-alkylpiperazine and a N-arylpiperazine. It has a role as a serotonergic antagonist, a dopaminergic antagonist, a histamine antagonist, an adrenergic antagonist and a second generation antipsychotic. |
| Classification | Small molecule |
| Drug class | tricyclic compounds; antipsychotics (dibenzothiazepine derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | OCCOCCN1CCN(C2=Nc3ccccc3Sc3ccccc32)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 111974-69-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL716 |
| ChEBI ID | 8707 |
| PubChem CID | 5002 |
| DrugBank | DB01224 |
| UNII ID | BGL0JSY5SI (ChemIDplus, GSRS) |
Target
Alternate
HTR1D
HTR1D
HTR1A
HTR1A
HRH1
HRH1
HTR1E
HTR1E
HTR1F
HTR1F
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
HTR1D
Gene synonyms
HTR1DA, HTRL
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 1D
Protein synonyms
5-HT-1D, 5-HT-1D-alpha, 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled, Serotonin 1D alpha receptor, Serotonin receptor 1D
Uniprot ID
Mouse ortholog
Htr1d (15552)
5-hydroxytryptamine receptor 1D (Q8BUW7)
Variants
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Financial
Revenue by drug
$
€
£
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Seroquel – AstraZeneca
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Estimated US medical usage
Quetiapine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 21,036 documents
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Safety
Black-box Warning
Black-box warning for: Quetiapine, Quetiapine fumarate, Quetiapine fumarate er, Seroquel, Seroquel xr
Adverse Events
Top Adverse Reactions
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138,833 adverse events reported
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