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Drug ReportsPyrilamine
Pyrilamine
Prefrin-a (pyrilamine) is a small molecule pharmaceutical. Pyrilamine was first approved as Prefrin-a on 1982-01-01. It is used to treat allergic conjunctivitis, allergic rhinitis perennial, allergic rhinitis seasonal, and pruritus in the USA. The pharmaceutical is active against histamine H1 receptor. In addition, it is known to target histamine H4 receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
eye diseasesD005128
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phenylephrine hydrochloride
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Pyrilamine maleate
Tradename
Company
Number
Date
Products
PREFRIN-AAllerganN-007953 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
acetaminophen 500mg caffeine 60mg pyrilamine maleate 15mgC2002632024-12-25
broncochemC2002632025-03-23
buscapinaC2002632024-12-03
capron dmC2002632025-06-18
capron dmtunapproved drug other2024-11-29
capron maxC2002632025-06-11
childrens pediaclear 8C2002632025-10-03
comfort-timeOTC monograph not final2018-12-14
cramp tabsC2002632024-10-04
curahist dmC2002632024-04-04
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
septic shock—D012772A48.3
hypotensionEFO_0005251D007022I95
pruritus—D011537L29
pruritus ani—D011538L29.0
open-angle glaucomaEFO_0004190D005902H40.1
fissure in ano—D005401K60.2
allergic conjunctivitisEFO_0007141D003233H10.44
allergic rhinitis seasonalEFO_0003956D006255J30
allergic rhinitis perennialEFO_1001417D012221J30.89
hemorrhoidsEFO_0009552D006484K64
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AA: Antihistamines for topical use
— D04AA02: Mepyramine
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03D: Other systemic drugs for obstructive airway diseases in atc
— R03DA: Xanthines, systemic for obstructive airway disease
— R03DA12: Mepyramine theophyllinacetate
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AC: Substituted ethylene diamines, systemic antihistamines
— R06AC01: Mepyramine
HCPCS
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Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Nasal obstructionD015508————1——1
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peripheral nervous system diseasesD010523—G64————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePyrilamine
INNmepyramine
Description
Mepyramine is an ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group. It has a role as a H1-receptor antagonist. It is an ethylenediamine derivative and an aromatic ether.
Classification
Small molecule
Drug classFirst-generation antihistamine
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Structure (InChI/SMILES or Protein Sequence)
COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
Identifiers
PDB—
CAS-ID91-84-9
RxCUI—
ChEMBL IDCHEMBL511
ChEBI ID6762
PubChem CID4992
DrugBankDB06691
UNII IDHPE317O9TL (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
3269
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Q6P9E5
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
HRH4
HRH4
Organism
Homo sapiens
Gene name
HRH4
Gene synonyms
GPCR105
NCBI Gene ID
59340
Protein name
histamine H4 receptor
Protein synonyms
AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144
Uniprot ID
Q9H3N8
Mouse ortholog
Hrh4 (225192)
histamine H4 receptor (Q91ZY2)
Variants
No data
Financial
Revenue by drug
$
€
£
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Estimated US medical usage
Pyrilamine
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Pentoxyverine
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Phenylephrine
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Pyrilamine
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Pentoxyverine
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Pyrilamine
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Chlophedianol
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Pyrilamine
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Phenylephrine
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Chlorpheniramine
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Pyrilamine
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Dextromethorphan
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Phenylephrine
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Pyrilamine
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Dextromethorphan
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Pyrilamine
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Phenylephrine
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Hydrocodone
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Pyrilamine
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Phenylephrine
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Trends
PubMed Central
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Additional graphs summarizing 3,234 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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268 adverse events reported
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