Pyrazinamide
Pyrazinamide, Rifater (pyrazinamide) is a small molecule pharmaceutical. Pyrazinamide was first approved as Pyrazinamide on 1982-01-01. It is used to treat mycobacterium infections and tuberculosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| mycobacterium infections | — | D009164 | A31.9 |
| tuberculosis | EFO_0000774 | D014376 | A15-A19 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AK: Other drugs for treatment of tuberculosis in atc
— J04AK01: Pyrazinamide
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM05: Rifampicin, pyrazinamide and isoniazid
— J04AM06: Rifampicin, pyrazinamide, ethambutol and isoniazid
HCPCS
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Clinical
Clinical Trials
174 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 9 | 30 | 19 | 6 | 17 | 75 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | 3 | 36 | 15 | 5 | 7 | 58 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 4 | 6 | 5 | 6 | 21 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | — | 6 | 8 | 4 | 4 | 20 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | — | — | 1 | 2 | 3 |
| Spinal tuberculosis | D014399 | — | A18.01 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Meningeal tuberculosis | D014390 | — | A17.0 | 1 | 7 | 2 | — | — | 8 |
| Hiv | D006678 | — | O98.7 | — | 2 | 2 | — | 1 | 5 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 1 | 2 | — | 1 | 3 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | 1 | — | — | 2 |
| Extensively drug-resistant tuberculosis | D054908 | — | — | — | 1 | 2 | — | — | 2 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 1 | 1 | — | — | 1 |
| Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | — | 1 | 1 | — | — | 1 |
| Anterior uveitis | D014606 | EFO_1000811 | — | — | — | 1 | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | — | — | 1 |
| Bacterial infections | D001424 | — | A49 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sars-cov-2 | D000086402 | — | — | — | 1 | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | — | 1 | — | — | — | 1 |
| Aids-related complex | D000386 | EFO_0007137 | B20 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Body weight changes | D001836 | — | — | — | — | — | — | 1 | 1 |
| Motor activity | D009043 | EFO_0003940 | — | — | — | — | — | 1 | 1 |
| Coinfection | D060085 | — | — | — | — | — | — | 1 | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pyrazinamide |
| INN | pyrazinamide |
| Description | Pyrazinecarboxamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis. It has a role as an antitubercular agent and a prodrug. It is a member of pyrazines, a N-acylammonia and a monocarboxylic acid amide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)c1cnccn1 |
Identifiers
| PDB | — |
| CAS-ID | 98-96-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL614 |
| ChEBI ID | 45285 |
| PubChem CID | 1046 |
| DrugBank | DB00339 |
| UNII ID | 2KNI5N06TI (ChemIDplus, GSRS) |
Target
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Financial
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Estimated US medical usage
Pyrazinamide
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Trends
PubMed Central
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Safety
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Adverse Events
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8,764 adverse events reported
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