Pyrazinamide
Pyrazinamide, Rifater (pyrazinamide) is a small molecule pharmaceutical. Pyrazinamide was first approved as Pyrazinamide on 1982-01-01. It is used to treat mycobacterium infections and tuberculosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
Pyrazinamide
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| pyrazinamide | ANDA | 2024-10-16 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AK: Other drugs for treatment of tuberculosis in atc
— J04AK01: Pyrazinamide
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM05: Rifampicin, pyrazinamide and isoniazid
— J04AM06: Rifampicin, pyrazinamide, ethambutol and isoniazid
HCPCS
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Clinical
Clinical Trials
215 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 3 | 1 | — | — | 4 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | 2 | 1 | — | — | 3 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pyrazinamide |
| INN | pyrazinamide |
| Description | Pyrazinecarboxamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis. It has a role as an antitubercular agent and a prodrug. It is a member of pyrazines, a N-acylammonia and a monocarboxylic acid amide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)c1cnccn1 |
Identifiers
| PDB | — |
| CAS-ID | 98-96-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL614 |
| ChEBI ID | 45285 |
| PubChem CID | 1046 |
| DrugBank | DB00339 |
| UNII ID | 2KNI5N06TI (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Pyrazinamide
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 31,857 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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11,120 adverse events reported
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