Pyrazinamide
Pyrazinamide, Rifater (pyrazinamide) is a small molecule pharmaceutical. Pyrazinamide was first approved as Pyrazinamide on 1982-01-01. It is used to treat mycobacterium infections and tuberculosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
Pyrazinamide
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| pyrazinamide | ANDA | 2026-03-02 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AK: Other drugs for treatment of tuberculosis in atc
— J04AK01: Pyrazinamide
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM05: Rifampicin, pyrazinamide and isoniazid
— J04AM06: Rifampicin, pyrazinamide, ethambutol and isoniazid
HCPCS
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Clinical
Clinical Trials
245 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 16 | 68 | 35 | 15 | 29 | 150 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | 5 | 49 | 26 | 5 | 8 | 83 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | — | 10 | 12 | 5 | 5 | 30 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 7 | 9 | 5 | 7 | 28 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | 3 | 6 | 2 | 6 | 16 |
| Hepatitis | D006505 | — | K75.9 | — | 1 | — | 1 | 2 | 4 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | 1 | 1 | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | 1 | 1 | 2 |
| Chemical and drug induced liver injury | D056486 | EFO_0004228 | — | 1 | — | — | 1 | — | 2 |
| Conduct disorder | D019955 | EFO_0004216 | F91 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Meningeal tuberculosis | D014390 | — | A17.0 | 1 | 10 | 3 | — | — | 12 |
| Hiv | D006678 | — | O98.7 | 1 | 3 | 2 | — | 2 | 8 |
| Aids-related opportunistic infections | D017088 | — | — | — | — | 1 | — | 4 | 5 |
| Latent tuberculosis | D055985 | — | Z22.7 | 1 | 2 | 1 | — | 2 | 5 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | 1 | 1 | — | 1 | 3 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | 1 | — | 2 | — | — | 3 |
| Extensively drug-resistant tuberculosis | D054908 | — | — | — | 2 | 2 | — | — | 3 |
| Infections | D007239 | EFO_0000544 | — | — | — | 2 | — | — | 2 |
| Coinfection | D060085 | — | — | — | — | 1 | — | 1 | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | 1 | — | — | 2 |
Show 22 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aids-related complex | D000386 | EFO_0007137 | B20 | — | 1 | — | — | 2 | 3 |
| Meningitis | D008581 | EFO_0000584 | G03 | — | 3 | — | — | — | 3 |
| Carcinoma | D002277 | — | C80.0 | 1 | 2 | — | — | 1 | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 1 | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 1 | 1 | — | — | — | 2 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 1 | — | — | 1 | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | — | — | 1 | 2 |
| Gram-positive bacterial infections | D016908 | — | — | 1 | 1 | — | — | — | 1 |
| Sars-cov-2 | D000086402 | — | — | — | 1 | — | — | — | 1 |
| Hepatitis c | D006526 | — | B19.2 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | — | — | — | — | 2 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | — | 1 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 1 | — | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Magnetic resonance imaging | D008279 | — | — | 1 | — | — | — | — | 1 |
| Overweight | D050177 | — | E66.3 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | — | — | — | 3 | 3 |
| Ocular hypotension | D015814 | — | H44.4 | — | — | — | — | 1 | 1 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | — | — | 1 | 1 |
| Body weight | D001835 | EFO_0004338 | — | — | — | — | — | 1 | 1 |
| Wasting syndrome | D019282 | — | — | — | — | — | — | 1 | 1 |
| Body weight changes | D001836 | — | — | — | — | — | — | 1 | 1 |
| Motor activity | D009043 | EFO_0003940 | — | — | — | — | — | 1 | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | — | — | 1 | 1 |
Show 17 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pyrazinamide |
| INN | pyrazinamide |
| Description | Pyrazinecarboxamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis. It has a role as an antitubercular agent and a prodrug. It is a member of pyrazines, a N-acylammonia and a monocarboxylic acid amide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)c1cnccn1 |
Identifiers
| PDB | — |
| CAS-ID | 98-96-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL614 |
| ChEBI ID | 45285 |
| PubChem CID | 1046 |
| DrugBank | DB00339 |
| UNII ID | 2KNI5N06TI (ChemIDplus, GSRS) |
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Estimated US medical usage
Pyrazinamide
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Trends
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Safety
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Adverse Events
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12,246 adverse events reported
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