Protirelin
Thypinone, Thyrel (protirelin) is a protein pharmaceutical. Protirelin was first approved as Thypinone on 1982-01-01. The pharmaceutical is active against thyrotropin-releasing hormone receptor.
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Protirelin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| THYPINONE | Abbott Biotherapeutics | N-017638 DISCN | 1982-01-01 | 1 products |
| THYREL TRH | Ferring Pharmaceuticals | N-018087 DISCN | 1982-01-01 | 1 products |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| thryotropin releasing hormone | unapproved drug other | 2012-06-19 |
| thyrotropin releasing hormone | unapproved drug other | 2012-06-19 |
Indications
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| J2725 | Injection, protirelin, per 250 mcg |
Clinical
Clinical Trials
38 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fertilization in vitro | D005307 | — | — | — | — | — | 2 | — | 2 |
| Oocyte donation | D018587 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinocerebellar degenerations | D013132 | — | G11 | — | 3 | 4 | — | — | 7 |
| Spinocerebellar ataxias | D020754 | — | — | — | 2 | 4 | — | — | 6 |
| Infertility | D007246 | EFO_0000545 | — | — | 1 | 2 | — | 1 | 4 |
| Ovulation induction | D010062 | — | — | — | 1 | 1 | — | — | 2 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | 1 | — | 1 | 2 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | — | 1 | — | 1 | 2 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thyroid diseases | D013959 | — | E00-E07 | — | 2 | — | — | 2 | 4 |
| Healthy volunteers/patients | — | — | — | 2 | 1 | — | — | 1 | 4 |
| Pituitary diseases | D010900 | — | E23.7 | — | 1 | — | — | 1 | 2 |
| Goiter | D006042 | EFO_0004283 | E04.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | — | — | — | — | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypothyroidism | D007037 | EFO_0004705 | E03.9 | — | — | — | — | 2 | 2 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Laron syndrome | D046150 | Orphanet_633 | E34.321 | — | — | — | — | 1 | 1 |
| Chromosome aberrations | D002869 | Orphanet_68335 | — | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | — | — | — | 1 | 1 |
| Neuroendocrine carcinoma | D018278 | — | — | — | — | — | — | 1 | 1 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 1 | 1 |
| Acute kidney injury | D058186 | — | N17 | — | — | — | — | 1 | 1 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Protirelin |
| INN | protirelin |
| Description | Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide. |
| Classification | Peptide |
| Drug class | prehormones or hormone-release stimulating peptides: thyrotropin releasing hormone analogues |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 |
Identifiers
| PDB | — |
| CAS-ID | 24305-27-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1472 |
| ChEBI ID | 35940 |
| PubChem CID | — |
| DrugBank | DB09421 |
| UNII ID | 5Y5F15120W (ChemIDplus, GSRS) |
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20 adverse events reported
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