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AboutPricing
Drug ReportsProtirelin
Protirelin
Thypinone, Thyrel (protirelin) is a protein pharmaceutical. Protirelin was first approved as Thypinone on 1982-01-01. The pharmaceutical is active against thyrotropin-releasing hormone receptor.
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Protirelin
Tradename
Company
Number
Date
Products
THYPINONEAbbott BiotherapeuticsN-017638 DISCN1982-01-01
1 products
THYREL TRHFerring PharmaceuticalsN-018087 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
thryotropin releasing hormoneunapproved drug other2012-06-19
thyrotropin releasing hormoneunapproved drug other2012-06-19
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CJ: Thyreoidea function test diagnostic agents
— V04CJ02: Protirelin
HCPCS
Code
Description
J2725
Injection, protirelin, per 250 mcg
Clinical
Clinical Trials
38 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfertilityD007246EFO_0000545———1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameProtirelin
INNprotirelin
Description
Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide.
Classification
Peptide
Drug classprehormones or hormone-release stimulating peptides: thyrotropin releasing hormone analogues
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
Identifiers
PDB—
CAS-ID24305-27-9
RxCUI—
ChEMBL IDCHEMBL1472
ChEBI ID35940
PubChem CID—
DrugBankDB09421
UNII ID5Y5F15120W (ChemIDplus, GSRS)
Target
Agency Approved
TRHR
TRHR
Organism
Homo sapiens
Gene name
TRHR
Gene synonyms
NCBI Gene ID
7201
Protein name
thyrotropin-releasing hormone receptor
Protein synonyms
Thyroliberin receptor
Uniprot ID
Q2M339
Mouse ortholog
Trhr (22045)
thyrotropin-releasing hormone receptor (P21761)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 15,750 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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20 adverse events reported
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