Propranolol - PharmaKB

Inderide-40/25, Hemangiol(propranolol)

Hemangeol, Hemangiol, Inderal, Inderide, Inderide-, Innopran, Propranolol (propranolol) is a small molecule pharmaceutical. Propranolol was first approved as Inderide-40/25 on 1982-01-01. It is used to treat angina pectoris, esophageal and gastric varices, essential tremor, heart failure, and hypertension amongst others in the USA. It has been approved in Europe to treat hemangioma. The pharmaceutical is active against beta-1 adrenergic receptor, beta-2 adrenergic receptor, and beta-3 adrenergic receptor. In addition, it is known to target 5-hydroxytryptamine receptor 5A, hepatic sodium/bile acid cotransporter, and 5-hydroxytryptamine receptor 1A.

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Financial

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FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

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Completion date

Results first post date

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
neoplasms	D009369
digestive system diseases	D004066
nervous system diseases	D009422
cardiovascular diseases	D002318
signs and symptoms pathological conditions	D013568
mental disorders	D001523

Trade Name

FDA

EMA

Hemangeol, Inderal, Innopran (generic drugs available since 1985-10-22)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Hydrochlorothiazide

Propranolol hydrochloride

Tradename	Company	Number	Date	Products
INDERIDE LA 80/50	Wyeth	N-019059 DISCN	1985-07-03	1 products
INDERIDE LA 120/50	Wyeth	N-019059 DISCN	1985-07-03	1 products
INDERIDE LA 160/50	Wyeth	N-019059 DISCN	1985-07-03	1 products
INDERIDE-40/25	WYETH PHARMS INC	N-018031 DISCN	1982-01-01	1 products, RLD
INDERIDE-80/25	WYETH PHARMS INC	N-018031 DISCN	1982-01-01	1 products, RLD

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Propranolol hydrochloride

Tradename	Company	Number	Date	Products
INDERAL LA	ANI PHARMS	N-018553 RX	1983-04-19	4 products, RLD
INNOPRAN XL	ANI PHARMS	N-021438 RX	2003-03-12	2 products, RLD, RS
HEMANGEOL	Laboratoires Pierre Fabre	N-205410 RX	2014-03-14	1 products, RLD, RS

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Labels

FDA

EMA

No data

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
angina pectoris	EFO_0003913	D000787	I20
esophageal and gastric varices	EFO_0009545	D004932	I85
essential tremor	EFO_0003108	D020329	G25.0
heart failure	EFO_0003144	D006333	I50
hypertension	EFO_0000537	D006973	I10
myocardial infarction	EFO_0000612	D009203	I21
panic disorder	EFO_0004262	D016584	F41.0
pheochromocytoma	—	D010673	—
supraventricular tachycardia	HP_0004755	D013617	I47.1
ventricular fibrillation	EFO_0004287	D014693	I49.01

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Agency Specific

FDA

EMA

No data

Patent Expiration

Patent	Expires	FDA Information
Propranolol Hydrochloride, Hemangeol, Pierre Fabre Derma
8338489	2028-10-16	U-1496
8987262	2028-10-16	U-1988

ATC Codes

C: Cardiovascular system drugs

— C07: Beta-adrenergic blocking agents

— C07A: Beta blocking agents

— C07AA: Beta blocking agents, non-selective

— C07AA05: Propranolol

— C07B: Beta blocking agents and thiazides

— C07BA: Beta blocking agents, non-selective, and thiazides

— C07BA05: Propranolol and thiazides

— C07F: Beta blocking agents, other combinations

— C07FX: Beta blocking agents, other combinations

— C07FX01: Propranolol and other combinations

HCPCS

Code	Description
J1800	Injection, propranolol hcl, up to 1 mg

Clinical

Clinical Trials

373 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Liver cirrhosis	D008103	EFO_0001422	K74.0	1	4	11	10	14	36
Post-traumatic stress disorders	D013313	EFO_0001358	F43.1	4	13	5	6	3	28
Portal hypertension	D006975	EFO_0000666	K76.6	1	2	6	2	12	21
Esophageal and gastric varices	D004932	EFO_0009545	I85	1	—	4	6	5	16
Migraine disorders	D008881	EFO_0003821	G43	—	1	2	4	4	11
Hemangioma	D006391	—	D18.0	1	4	2	1	4	11
Traumatic brain injuries	D000070642	—	S06	2	3	1	3	—	8
Heart diseases	D006331	EFO_0003777	I51.9	—	—	2	5	—	7
Hypertension	D006973	EFO_0000537	I10	—	1	1	1	3	5
Postural orthostatic tachycardia syndrome	D054972	—	G90.A	1	1	—	1	2	5

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Healthy volunteers/patients	—	—	—	11	3	1	—	4	18
Retinopathy of prematurity	D012178	EFO_1001158	H35.1	1	6	1	—	1	7
Burns	D002056	—	T30.0	—	6	5	—	1	7
Cardiac arrhythmias	D001145	EFO_0004269	I49.9	—	—	1	—	3	4
Migraine without aura	D020326	EFO_0005296	G43.0	—	1	2	—	1	3
Melanoma	D008545	—	—	1	2	1	—	—	3
Supraventricular tachycardia	D013617	HP_0004755	I47.1	—	—	1	—	2	3
Adjustment disorders	D000275	—	F43.2	—	3	1	—	—	3
Trauma and stressor related disorders	D000068099	—	F43.9	—	3	1	—	—	3
Covid-19	D000086382	—	U07.1	—	—	1	—	1	2

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Cocaine-related disorders	D019970	—	F14	2	4	—	—	1	7
Orthostatic intolerance	D054971	—	—	2	1	—	—	1	3
Breast neoplasms	D001943	EFO_0003869	C50	1	2	—	—	—	3
Cavernous hemangioma central nervous system	D020786	EFO_1001343	—	1	2	—	—	—	3
Prostatic neoplasms	D011471	—	C61	—	3	—	—	—	3
Traumatic stress disorders acute	D040701	EFO_0005223	F43.0	—	3	—	—	—	3
Fibromyalgia	D005356	EFO_0005687	M79.1	1	2	—	—	—	3
Multiple myeloma	D009101	—	C90.0	—	2	—	—	1	3
Tachycardia	D013610	HP_0001649	R00.0	1	1	—	—	1	2
Type 1 diabetes mellitus	D003922	EFO_0001359	E10	1	1	—	—	—	2

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Chronic obstructive pulmonary disease	D029424	EFO_0000341	J44.9	2	—	—	—	1	3
Ovarian epithelial carcinoma	D000077216	—	—	2	—	—	—	1	3
Fallopian tube neoplasms	D005185	—	—	2	—	—	—	1	3
Obesity	D009765	EFO_0001073	E66.9	1	—	—	—	1	2
Ovarian neoplasms	D010051	EFO_0003893	C56	1	—	—	—	1	2
Kidney diseases	D007674	EFO_0003086	N08	1	—	—	—	—	1
Stem cell transplantation	D033581	—	—	1	—	—	—	—	1
Hypoglycemia	D007003	HP_0001943	E16.2	1	—	—	—	—	1
Prediabetic state	D011236	EFO_1001121	R73.03	1	—	—	—	—	1
Metabolic syndrome	D024821	EFO_0000195	E88.810	1	—	—	—	—	1

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Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Atrial fibrillation	D001281	EFO_0000275	I48.0	—	—	—	—	4	4
Fibrosis	D005355	—	—	—	—	—	—	3	3
Autistic disorder	D001321	HP_0000717	F84.0	—	—	—	—	2	2
Drug-related side effects and adverse reactions	D064420	—	T88.7	—	—	—	—	1	1
Drug interactions	D004347	—	—	—	—	—	—	1	1
Insulin resistance	D007333	HP_0000855	E88.819	—	—	—	—	1	1
Orthodontic extrusion	D050793	—	—	—	—	—	—	1	1
Exercise test	D005080	EFO_0004328	—	—	—	—	—	1	1
Transjugular intrahepatic portasystemic shunt	D019168	—	—	—	—	—	—	1	1
Uterine cervical neoplasms	D002583	HP_0030159	—	—	—	—	—	1	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Propranolol
INN	propranolol
Description	Propranolol is a propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3. It has a role as a beta-adrenergic antagonist, an anxiolytic drug, an anti-arrhythmia drug, a vasodilator agent, an antihypertensive agent, a xenobiotic, an environmental contaminant and a human blood serum metabolite. It is a secondary amine, a propanolamine and a member of naphthalenes. It is functionally related to a 1-naphthol.
Classification	Small molecule
Drug class	beta-blockers (propranolol type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC(C)NCC(O)COc1cccc2ccccc12

Identifiers

PDB	—
CAS-ID	525-66-6
RxCUI	—
ChEMBL ID	CHEMBL27
ChEBI ID	8499
PubChem CID	4946
DrugBank	DB00571
UNII ID	9Y8NXQ24VQ (ChemIDplus, GSRS)

Target

Agency Approved

ADRB1

ADRB2

ADRB3

Organism

Homo sapiens

Gene name

ADRB1

Gene synonyms

ADRB1R, B1AR

NCBI Gene ID

153

Protein name

beta-1 adrenergic receptor

Protein synonyms

adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor

Uniprot ID

Q9UKG8

Mouse ortholog

Adrb1 (11554)

beta-1 adrenergic receptor (P34971)

Alternate

HTR5A

SLC10A1

HTR1A

Organism

Homo sapiens

Gene name

HTR5A

Gene synonyms

NCBI Gene ID

3361

Protein name

5-hydroxytryptamine receptor 5A

Protein synonyms

5-HT-5, 5-HT-5A, 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled, Serotonin receptor 5A

Uniprot ID

Q2M2D2

Mouse ortholog

Htr5a (15563)

5-hydroxytryptamine receptor 5A (Q3URB0)

Variants

No data

Financial

Revenue by drug

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No data

Estimated US medical usage

Propranolol

Hydrochlorothiazide

Total medical expenditures per year (USD, in millions)

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Propranolol

Total medical expenditures per year (USD, in millions)

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Trends

PubMed Central

Top Terms for Disease or Syndrome:

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Additional graphs summarizing 39,969 documents

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Safety

Black-box Warning

No Black-box warning

Adverse Events

Top Adverse Reactions

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14,000 adverse events reported

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