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Drug ReportsPropranolol
Propranolol hydrochloride, Hemangiol(propranolol)
Hemangeol, Hemangiol, Inderal, Inderide, Inderide-, Innopran, Propranolol (propranolol) is a small molecule pharmaceutical. Propranolol was first approved as Inderide-40/25 on 1982-01-01. It is used to treat angina pectoris, esophageal and gastric varices, essential tremor, heart failure, and hypertension amongst others in the USA. It has been approved in Europe to treat hemangioma. The pharmaceutical is active against beta-1 adrenergic receptor, beta-2 adrenergic receptor, and beta-3 adrenergic receptor. In addition, it is known to target 5-hydroxytryptamine receptor 5A, hepatic sodium/bile acid cotransporter, and 5-hydroxytryptamine receptor 1A.
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Drug
Target
Variants
Financial
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
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FDA approval date
EMA approval date
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Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
digestive system diseasesD004066
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
Hemangeol, Inderal, Innopran, Propranolol (discontinued: Inderal, Propranolol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Propranolol hydrochloride
Tradename
Company
Number
Date
Products
INDERAL LAANI PharmaceuticalsN-018553 RX1983-04-19
4 products, RLD
INNOPRAN XLANI PharmaceuticalsN-021438 RX2003-03-12
2 products, RLD, RS
HEMANGEOLLaboratoires Pierre FabreN-205410 RX2014-03-14
1 products, RLD, RS
Show 3 discontinued
Hydrochlorothiazide
+
Propranolol hydrochloride
Tradename
Company
Number
Date
Products
INDERIDE LA 80/50WyethN-019059 DISCN1985-07-03
1 products
INDERIDE LA 120/50WyethN-019059 DISCN1985-07-03
1 products
INDERIDE LA 160/50WyethN-019059 DISCN1985-07-03
1 products
INDERIDE-40/25WyethN-018031 DISCN1982-01-01
1 products, RLD
INDERIDE-80/25WyethN-018031 DISCN1982-01-01
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
hemangeolNew Drug Application2024-11-06
inderalNew Drug Application2024-08-01
inderal xlNew Drug Application2024-03-20
innopran xlNew Drug Application2024-03-20
metoclopramideANDA2012-08-29
propranololANDA2024-07-15
propranolol hcl er propranolol hydrochloride erANDA, NDA authorized generic2019-04-19
propranolol hydrochlorideANDA2025-10-01
propranolol hyrochlorideANDA2014-05-15
propranolol scopolamineunapproved drug other2014-10-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
myocardial infarctionEFO_0000612D009203I21
pheochromocytoma—D010673—
angina pectorisEFO_0003913D000787I20
ventricular tachycardia—D017180I47.2
essential tremorEFO_0003108D020329G25.0
esophageal and gastric varicesEFO_0009545D004932I85
ventricular fibrillationEFO_0004287D014693I49.01
supraventricular tachycardia—D013617I47.1
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Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Propranolol Hydrochloride, Hemangeol, Pierre Fabre Derma
83384892028-10-16U-1496
89872622028-10-16U-1988
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AA: Beta blocking agents, non-selective
— C07AA05: Propranolol
— C07B: Beta blocking agents and thiazides
— C07BA: Beta blocking agents, non-selective, and thiazides
— C07BA05: Propranolol and thiazides
— C07F: Beta blocking agents, other combinations
— C07FX: Beta blocking agents, other combinations
— C07FX01: Propranolol and other combinations
HCPCS
Code
Description
J1800
Injection, propranolol hcl, up to 1 mg
Clinical
Clinical Trials
410 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePropranolol
INNpropranolol
Description
Propranolol is a propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3. It has a role as a beta-adrenergic antagonist, an anxiolytic drug, an anti-arrhythmia drug, a vasodilator agent, an antihypertensive agent, a xenobiotic, an environmental contaminant and a human blood serum metabolite. It is a secondary amine, a propanolamine and a member of naphthalenes. It is functionally related to a 1-naphthol.
Classification
Small molecule
Drug classbeta-blockers (propranolol type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)NCC(O)COc1cccc2ccccc12
Identifiers
PDB—
CAS-ID525-66-6
RxCUI—
ChEMBL IDCHEMBL27
ChEBI ID8499
PubChem CID4946
DrugBankDB00571
UNII ID9Y8NXQ24VQ (ChemIDplus, GSRS)
Target
Agency Approved
ADRB1
ADRB1
ADRB2
ADRB2
ADRB3
ADRB3
Organism
Homo sapiens
Gene name
ADRB1
Gene synonyms
ADRB1R, B1AR
NCBI Gene ID
153
Protein name
beta-1 adrenergic receptor
Protein synonyms
adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Uniprot ID
Q9UKG8
Mouse ortholog
Adrb1 (11554)
beta-1 adrenergic receptor (P34971)
Alternate
HTR5A
HTR5A
SLC10A1
SLC10A1
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
HTR5A
Gene synonyms
NCBI Gene ID
3361
Protein name
5-hydroxytryptamine receptor 5A
Protein synonyms
5-HT-5, 5-HT-5A, 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled, Serotonin receptor 5A
Uniprot ID
Q2M2D2
Mouse ortholog
Htr5a (15563)
5-hydroxytryptamine receptor 5A (Q3URB0)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Propranolol
+
Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Propranolol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 44,811 documents
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Safety
Black-box Warning
Black-box warning for: Metoclopramide
Adverse Events
Top Adverse Reactions
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27,175 adverse events reported
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