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Drug ReportsPropoxyphene
Propoxyphene
Darvocet, Darvon, Dolene, Kesso-gesic, Prophene, Wygesic (propoxyphene) is a small molecule pharmaceutical. Propoxyphene was first approved as Darvocet on 1982-01-01. It is used to treat pain in the USA.
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Drug
Target
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Events Timeline
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FDA approval date
EMA approval date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
+
Propoxyphene hydrochloride
Tradename
Company
Number
Date
Products
DARVON W/ ASAXanodyne PharmaceuticalsN-010996 DISCN1982-01-01
1 products
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Aspirin
+
Caffeine
+
Propoxyphene hydrochloride
Tradename
Company
Number
Date
Products
DARVON COMPOUNDXanodyne PharmaceuticalsN-010996 DISCN1983-03-08
1 products
DARVON COMPOUND-65Xanodyne PharmaceuticalsN-010996 DISCN1983-03-08
1 products
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Propoxyphene hydrochloride
Tradename
Company
Number
Date
Products
DARVONXanodyne PharmaceuticalsN-010997 DISCN1982-01-01
2 products
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Acetaminophen
+
Propoxyphene hydrochloride
Tradename
Company
Number
Date
Products
DARVOCETAAIPharmaN-016844 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
darvon-nNew Drug Application2009-10-27
propoxypheneANDA2009-10-27
propoxyphene and acetaminophenANDA2010-08-03
propoxyphene hydrochloride and acetaminophen2007-02-16
propoxyphene napsylate and acetaminophenANDA2011-06-20
propoxyphene napsylate and acetominophen2008-11-18
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N02: Analgesics
N02A: Opioid analgesics
N02AC: Diphenylpropylamine derivative analgesics
N02AC04: Dextropropoxyphene
N02AC54: Dextropropoxyphene, combinations excl. psycholeptics
N02AC74: Dextropropoxyphene, combinations with psycholeptics
HCPCS
No data
Clinical
No data
Drug
General
Drug common namePropoxyphene
INNdextropropoxyphene
Description
Levopropoxyphene is a 1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate. It has a role as an antitussive. It is an enantiomer of a dextropropoxyphene.
Classification
Small molecule
Drug class
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Structure (InChI/SMILES or Protein Sequence)
CCC(=O)O[C@](Cc1ccccc1)(c1ccccc1)[C@H](C)CN(C)C
Identifiers
PDB
CAS-ID469-62-5
RxCUI
ChEMBL IDCHEMBL1213351
ChEBI ID51173
PubChem CID200742
DrugBankDB00647
UNII IDS2F83W92TK (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
No data
Estimated US medical usage
Propoxyphene
+
Acetaminophen
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Propoxyphene
Total medical expenditures per year (USD, in millions)
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Trends
No data
Safety
Black-box Warning
Black-box warning for: Darvon-n, Propoxyphene, Propoxyphene and acetaminophen
Adverse Events
0 adverse events reported
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