Propoxyphene
Darvocet, Darvon, Dolene, Kesso-gesic, Prophene, Wygesic (propoxyphene) is a small molecule pharmaceutical. Propoxyphene was first approved as Darvocet on 1982-01-01. It is used to treat pain in the USA.
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Abbreviated New Drug Application (ANDA)
Aspirin
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Propoxyphene hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DARVON W/ ASA | Xanodyne Pharmaceuticals | N-010996 DISCN | 1982-01-01 | 1 products |
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Aspirin
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Caffeine
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Propoxyphene hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DARVON COMPOUND | Xanodyne Pharmaceuticals | N-010996 DISCN | 1983-03-08 | 1 products |
| DARVON COMPOUND-65 | Xanodyne Pharmaceuticals | N-010996 DISCN | 1983-03-08 | 1 products |
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Propoxyphene hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DARVON | Xanodyne Pharmaceuticals | N-010997 DISCN | 1982-01-01 | 2 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| darvon-n | New Drug Application | 2009-10-27 |
| propoxyphene | ANDA | 2009-10-27 |
| propoxyphene and acetaminophen | ANDA | 2010-08-03 |
| propoxyphene hydrochloride and acetaminophen | 2007-02-16 | |
| propoxyphene napsylate and acetaminophen | ANDA | 2011-06-20 |
| propoxyphene napsylate and acetominophen | 2008-11-18 |
Indications
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4 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | — | — | 1 | — | 1 |
| Cancer pain | D000072716 | — | G89.3 | — | — | — | 1 | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | 1 | — | 1 |
| Pathologic constriction | D003251 | — | — | — | — | — | 1 | — | 1 |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | — | — | — | 1 | — | 1 |
| Healthy volunteers/patients | — | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | — | 1 | 1 | — | — | 1 |
| Tissue adhesions | D000267 | — | — | — | 1 | 1 | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Propoxyphene |
| INN | dextropropoxyphene |
| Description | Levopropoxyphene is a 1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate. It has a role as an antitussive. It is an enantiomer of a dextropropoxyphene. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC(=O)O[C@](Cc1ccccc1)(c1ccccc1)[C@H](C)CN(C)C |
Identifiers
| PDB | — |
| CAS-ID | 469-62-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1213351 |
| ChEBI ID | 51173 |
| PubChem CID | 200742 |
| DrugBank | DB00647 |
| UNII ID | S2F83W92TK (ChemIDplus, GSRS) |
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Estimated US medical usage
Propoxyphene
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Acetaminophen
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Propoxyphene
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Safety
Black-box Warning
Black-box warning for: Darvon-n, Propoxyphene, Propoxyphene and acetaminophen
Adverse Events
Top Adverse Reactions
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12,991 adverse events reported
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