Propofol
Diprivan, Propofol (propofol) is a small molecule pharmaceutical. Propofol was first approved as Diprivan on 1989-10-02. It is used to treat delirium, pain, psychomotor agitation, and status epilepticus in the USA. It is known to target potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1.
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Commercial
Trade Name
FDA
EMA
Diprivan, Propofol (discontinued: Diprivan, Propofol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Propofol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DIPRIVAN | Fresenius Kabi | N-019627 RX | 1996-06-11 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| diprivan | New Drug Application | 2025-04-21 |
| propofol | ANDA | 2025-05-26 |
| propofol 1% | unapproved drug other | 2023-12-27 |
| propofol injectable emulsion | ANDA | 2022-09-30 |
| propofol lipuro | unapproved drug other | 2021-12-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
| delirium | — | D003693 | R41.0 |
| psychomotor agitation | — | D011595 | — |
| status epilepticus | EFO_0008526 | D013226 | G41 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2704 | Injection, propofol, 10 mg |
Clinical
Clinical Trials
2516 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| General anesthesia | D000768 | — | — | — | — | 1 | — | — | 1 |
| Elective surgical procedures | D017558 | — | — | — | — | 1 | — | — | 1 |
| Critical illness | D016638 | — | — | — | — | 1 | — | — | 1 |
| Nutrition therapy | D044623 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Subdural hematoma chronic | D020200 | — | — | 1 | 3 | — | — | 2 | 5 |
| Lung injury | D055370 | — | S27.30 | 1 | 1 | — | — | 4 | 5 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 1 | 1 | — | — | 2 | 4 |
| Traumatic stress disorders | D040921 | — | — | 1 | 1 | — | — | 2 | 4 |
| Airway remodeling | D056151 | — | — | — | 1 | — | — | 1 | 2 |
| Newborn infant diseases | D007232 | — | — | — | 1 | — | — | 1 | 2 |
| Intracranial pressure | D007427 | — | — | 1 | 1 | — | — | 1 | 2 |
| Obstructive lung diseases | D008173 | — | — | — | 1 | — | — | 1 | 2 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 2 | 2 | — | — | — | 2 |
| Radical mastectomy | D015409 | — | — | 1 | 1 | — | — | — | 1 |
Show 14 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | — | — | — | 7 | 8 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | 1 | — | — | — | 4 | 5 |
| Sleep deprivation | D012892 | — | F51.12 | 1 | — | — | — | 3 | 4 |
| Respiration disorders | D012120 | — | J00-J99 | 1 | — | — | — | 3 | 4 |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | 2 | — | — | — | 2 | 4 |
| Respiratory tract diseases | D012140 | — | — | 1 | — | — | — | 2 | 3 |
| Tympanic membrane perforation | D018058 | — | H72 | 1 | — | — | — | 1 | 2 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 2 | — | — | — | — | 2 |
| Parkinsonian disorders | D020734 | — | G20.C | 1 | — | — | — | 1 | 2 |
| Circadian rhythm | D002940 | EFO_0004354 | — | 1 | — | — | — | 1 | 2 |
Show 18 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiopulmonary bypass | D002315 | — | — | — | — | — | — | 6 | 6 |
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | — | — | — | — | 6 | 6 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | — | 6 | 6 |
| Colonic polyps | D003111 | — | K63.5 | — | — | — | — | 5 | 5 |
| One-lung ventilation | D061810 | — | — | — | — | — | — | 5 | 5 |
| Consciousness monitors | D056805 | — | — | — | — | — | — | 5 | 5 |
| Acute cholecystitis | D041881 | EFO_1001289 | K81.0 | — | — | — | — | 4 | 4 |
| Spinal diseases | D013122 | — | M45-M49 | — | — | — | — | 4 | 4 |
| Airway management | D058109 | — | — | — | — | — | — | 4 | 4 |
| Invasive hydatidiform mole | D002820 | — | D39.2 | — | — | — | — | 4 | 4 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Propofol |
| INN | propofol |
| Description | Propofol is a phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group. It has a role as an intravenous anaesthetic, a sedative, a radical scavenger, an antiemetic and an anticonvulsant. |
| Classification | Small molecule |
| Drug class | GABAA receptor agonist;sedative;general anesthetic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)c1cccc(C(C)C)c1O |
Identifiers
| PDB | — |
| CAS-ID | 2078-54-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL526 |
| ChEBI ID | 44915 |
| PubChem CID | 4943 |
| DrugBank | DB00818 |
| UNII ID | YI7VU623SF (ChemIDplus, GSRS) |
Target
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Diprivan – AstraZeneca
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Safety
Black-box Warning
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Adverse Events
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22,893 adverse events reported
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