Proparacaine
Alcaine, Proparacaine (proparacaine) is a small molecule pharmaceutical. Proparacaine was first approved as Ophthaine on 1982-01-01.
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Commercial
Therapeutic Areas
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Trade Name
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Alcaine, Proparacaine (discontinued: Ophthaine, Ophthetic)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Proparacaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| OPHTHETIC | Allergan | N-012583 DISCN | 1982-01-01 | 1 products, RLD |
| OPHTHAINE | Bristol Myers Squibb | N-008883 DISCN | 1982-01-01 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alcaine | ANDA | 2024-07-17 |
| fluorecein sodium and proparacaine hydrochloride | unapproved drug other | 2014-07-17 |
| fluorescein sodium and proparacaine hydrochloride | unapproved drug other | 2022-10-28 |
| proparacaine hydrochloride | ANDA | 2025-08-22 |
Indications
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Agency Specific
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Patent Expiration
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Clinical
Clinical Trials
61 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 1 | 1 |
| Dry eye syndromes | D015352 | — | H04.12 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Proparacaine |
| INN | proxymetacaine |
| Description | Proparacaine is a benzoate ester. |
| Classification | Small molecule |
| Drug class | local anesthetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCOc1ccc(C(=O)OCCN(CC)CC)cc1N |
Identifiers
| PDB | — |
| CAS-ID | 499-67-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1196 |
| ChEBI ID | 8485 |
| PubChem CID | 4935 |
| DrugBank | DB00807 |
| UNII ID | B4OB0JHI1X (ChemIDplus, GSRS) |
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Financial
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Estimated US medical usage
Proparacaine
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Trends
PubMed Central
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Additional graphs summarizing 7,531 documents
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Safety
Black-box Warning
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Adverse Events
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520 adverse events reported
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