Proparacaine
Alcaine, Proparacaine (proparacaine) is a small molecule pharmaceutical. Proparacaine was first approved as Ophthetic on 1982-01-01.
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Commercial
Therapeutic Areas
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Trade Name
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Alcaine, Proparacaine (discontinued: Ophthaine, Ophthetic)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Proparacaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| OPHTHETIC | Allergan | N-012583 DISCN | 1982-01-01 | 1 products, RLD |
| OPHTHAINE | Bristol Myers Squibb | N-008883 DISCN | 1982-01-01 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alcaine | ANDA | 2024-07-17 |
| fluorecein sodium and proparacaine hydrochloride | unapproved drug other | 2014-07-17 |
| fluorescein sodium and proparacaine hydrochloride | unapproved drug other | 2022-10-28 |
| proparacaine hydrochloride | ANDA | 2024-08-14 |
Indications
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Agency Specific
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Clinical
Clinical Trials
61 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | 1 | 4 | 6 |
| Cataract | D002386 | HP_0000518 | H26.9 | — | — | — | 1 | 4 | 5 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | 1 | 1 | 3 | 5 |
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | 1 | 2 | 3 |
| Astigmatism | D001251 | EFO_0004222 | H52.2 | — | — | — | 2 | 1 | 3 |
| Vitreous detachment | D020255 | EFO_1001238 | H43.81 | — | — | — | 1 | 1 | 2 |
| Refractive errors | D012030 | EFO_0003908 | H52.7 | — | — | — | 1 | 1 | 2 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | — | 1 | 1 | 2 |
| Dacryocystitis | D003607 | — | H04.0 | — | — | — | 2 | — | 2 |
| Lacrimal apparatus diseases | D007766 | HP_0009926 | H04 | — | — | — | 2 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Keratoconus | D007640 | EFO_0004223 | H18.6 | — | — | 1 | — | 5 | 6 |
| Local anesthesia | D000772 | — | — | — | — | 1 | — | 3 | 4 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | — | 1 | 2 |
| Ocular hypertension | D009798 | EFO_1001069 | H40.0 | — | — | 1 | — | 1 | 2 |
| Exfoliation syndrome | D017889 | EFO_0004235 | — | — | — | 1 | — | — | 1 |
| Pathologic dilatation | D004108 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinitis pigmentosa | D012174 | HP_0000580 | H35.52 | 1 | 1 | — | — | — | 2 |
| Retinitis | D012173 | — | H30.9 | 1 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Corneal injuries | D065306 | HP_0000559 | — | 1 | — | — | — | — | 1 |
| Retinoblastoma | D012175 | — | — | 1 | — | — | — | — | 1 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Nervous system diseases | D009422 | — | G00-G99 | 1 | — | — | — | — | 1 |
| Primary dysautonomias | D054969 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic intolerance | D054971 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | — | — | — | — | — | 4 | 4 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 4 | 4 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | — | — | — | — | 4 | 4 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | — | — | — | 3 | 3 |
| Dry eye syndromes | D015352 | — | H04.12 | — | — | — | — | 3 | 3 |
| Meibomian gland dysfunction | D000080343 | — | H02.88 | — | — | — | — | 3 | 3 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | — | 2 | 2 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 2 | 2 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | — | — | 2 | 2 |
| Eyelid diseases | D005141 | EFO_0009547 | H02.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Proparacaine |
| INN | proxymetacaine |
| Description | Proparacaine is a benzoate ester. |
| Classification | Small molecule |
| Drug class | local anesthetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCOc1ccc(C(=O)OCCN(CC)CC)cc1N |
Identifiers
| PDB | — |
| CAS-ID | 499-67-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1196 |
| ChEBI ID | 8485 |
| PubChem CID | 4935 |
| DrugBank | DB00807 |
| UNII ID | B4OB0JHI1X (ChemIDplus, GSRS) |
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Financial
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Proparacaine
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Trends
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Safety
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456 adverse events reported
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