Propafenone
Propafenone (propafenone) is a small molecule pharmaceutical. Propafenone was first approved as Rythmol on 1989-11-27. It is used to treat atrial fibrillation, cardiac arrhythmias, and supraventricular tachycardia in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target potassium voltage-gated channel subfamily A member 5 and beta-2 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Propafenone (discontinued: Propafenone, Rythmol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| propafenone | ANDA | 2011-04-13 |
| propafenone hcl | ANDA | 2019-10-09 |
| propafenone hydrochloride | ANDA | 2025-01-13 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
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HCPCS
No data
Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 2 | 7 | 7 | 22 | 38 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | 1 | — | 2 | 2 | 4 | 9 |
| Ventricular premature complexes | D018879 | — | I49.3 | — | — | — | 2 | 1 | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | 1 | — | 2 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | 1 | 1 | 2 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | 1 | — | 1 |
| Premature cardiac complexes | D005117 | — | I49.40 | — | — | — | 1 | — | 1 |
| Septic shock | D012772 | — | A48.3 | — | — | — | 1 | — | 1 |
| Shock | D012769 | — | R57.1 | — | — | — | 1 | — | 1 |
| Supraventricular tachycardia | D013617 | HP_0004755 | I47.1 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 1 | — | 2 | 3 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 2 | — | 1 | 3 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 2 | — | — | 2 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | — | 1 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | 1 | — | — | 1 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 1 | — | — | 1 |
| Ventricular fibrillation | D014693 | HP_0001663 | I49.01 | — | — | 1 | — | — | 1 |
| Ischemic stroke | D000083242 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Sick sinus syndrome | D012804 | EFO_0004275 | I49.5 | — | — | — | — | 1 | 1 |
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Atrial flutter | D001282 | EFO_0003911 | — | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Propafenone |
| INN | propafenone |
| Description | Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It is a secondary amino compound, a secondary alcohol and an aromatic ketone. It is a conjugate base of a propafenone(1+). |
| Classification | Small molecule |
| Drug class | antiarrhythmics (propafenone derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 54063-53-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL631 |
| ChEBI ID | 63619 |
| PubChem CID | 4932 |
| DrugBank | DB01182 |
| UNII ID | 68IQX3T69U (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
KCNA5
KCNA5
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
KCNA5
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily A member 5
Protein synonyms
cardiac potassium channel, HPCN1, insulinoma and islet potassium channel, potassium channel 1, potassium channel, voltage gated shaker related subfamily A, member 5, potassium voltage-gated channel, shaker-related subfamily, member 5, Voltage-gated potassium channel HK2, voltage-gated potassium channel protein Kv1.5, Voltage-gated potassium channel subunit Kv1.5
Uniprot ID
Mouse ortholog
Kcna5 (16493)
potassium voltage-gated channel subfamily A member 5 (Q9Z1R6)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Propafenone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,890 documents
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Safety
Black-box Warning
Black-box warning for: Propafenone hcl, Propafenone hydrochloride
Adverse Events
Top Adverse Reactions
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3,708 adverse events reported
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