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Drug ReportsPropafenone
Propafenone
Propafenone (propafenone) is a small molecule pharmaceutical. Propafenone was first approved as Rythmol on 1989-11-27. It is used to treat atrial fibrillation, cardiac arrhythmias, and supraventricular tachycardia in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target potassium voltage-gated channel subfamily A member 5 and beta-2 adrenergic receptor.
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EMA approval date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Propafenone (discontinued: Propafenone, Rythmol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Propafenone hydrochloride
Tradename
Company
Number
Date
Products
RYTHMOLGSKN-019151 DISCN1989-11-27
3 products, RLD
RYTHMOL SRGSKN-021416 DISCN2003-09-04
3 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
propafenoneANDA2011-04-13
propafenone hclANDA2019-10-09
propafenone hydrochlorideANDA2025-12-11
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
atrial fibrillationEFO_0000275D001281I48.0
cardiac arrhythmiasEFO_0004269D001145I49.9
supraventricular tachycardia—D013617I47.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01B: Antiarrhythmics, class i and iii
— C01BC: Antiarrhythmics, class ic
— C01BC03: Propafenone
HCPCS
No data
Clinical
Clinical Trials
51 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiac arrhythmiasD001145EFO_0004269I49.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePropafenone
INNpropafenone
Description
Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It is a secondary amino compound, a secondary alcohol and an aromatic ketone. It is a conjugate base of a propafenone(1+).
Classification
Small molecule
Drug classantiarrhythmics (propafenone derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1
Identifiers
PDB—
CAS-ID54063-53-5
RxCUI—
ChEMBL IDCHEMBL631
ChEBI ID63619
PubChem CID4932
DrugBankDB01182
UNII ID68IQX3T69U (ChemIDplus, GSRS)
Target
Agency Approved
ADRB1
ADRB1
Organism
Homo sapiens
Gene name
ADRB1
Gene synonyms
ADRB1R, B1AR
NCBI Gene ID
153
Protein name
beta-1 adrenergic receptor
Protein synonyms
adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Uniprot ID
Q9UKG8
Mouse ortholog
Adrb1 (11554)
beta-1 adrenergic receptor (P34971)
Alternate
KCNA5
KCNA5
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
KCNA5
Gene synonyms
NCBI Gene ID
3741
Protein name
potassium voltage-gated channel subfamily A member 5
Protein synonyms
cardiac potassium channel, HPCN1, insulinoma and islet potassium channel, potassium channel 1, potassium channel, voltage gated shaker related subfamily A, member 5, potassium voltage-gated channel, shaker-related subfamily, member 5, Voltage-gated potassium channel HK2, voltage-gated potassium channel protein Kv1.5, Voltage-gated potassium channel subunit Kv1.5
Uniprot ID
Q9UDA4
Mouse ortholog
Kcna5 (16493)
potassium voltage-gated channel subfamily A member 5 (Q9Z1R6)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Propafenone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,215 documents
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Safety
Black-box Warning
Black-box warning for: Propafenone hcl, Propafenone hydrochloride
Adverse Events
Top Adverse Reactions
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3,831 adverse events reported
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