Proguanil
Atovaquone / Proguanil, Malarone (proguanil) is a small molecule pharmaceutical. Proguanil was first approved as Malarone on 2000-07-14. It is used to treat falciparum malaria and malaria in the USA.
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Trade Name
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Combinations
Atovaquone proguanil, Malarone
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
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Brand Name | Status | Last Update |
|---|---|---|
| atovaquone and proguanil hcl | NDA authorized generic | 2023-10-23 |
| atovaquone and proguanil hydrochloride | ANDA | 2024-10-10 |
| atovaquone and proguanil hydrochloride atovaquone and proguanil hydrochloride pediatric | ANDA | 2019-12-31 |
| malarone | New Drug Application | 2023-11-14 |
Indications
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Drug
General
| Drug common name | Proguanil |
| INN | proguanil |
| Description | Proguanil is a biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells. It has a role as an antimalarial, an antiprotozoal drug and an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It is a member of biguanides and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 500-92-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1377 |
| ChEBI ID | 8455 |
| PubChem CID | 6178111 |
| DrugBank | DB01131 |
| UNII ID | S61K3P7B2V (ChemIDplus, GSRS) |
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Financial
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Estimated US medical usage
Proguanil
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Atovaquone
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