Prochlorperazine
Compro, Prochlorperazine, Procomp (prochlorperazine) is a small molecule pharmaceutical. Prochlorperazine was first approved as Compazine on 1982-01-01. It is used to treat anxiety disorders, dementia, nausea, psychotic disorders, and schizophrenia amongst others in the USA. The pharmaceutical is active against D(3) dopamine receptor and D(2) dopamine receptor. In addition, it is known to target D(1A) dopamine receptor and D(4) dopamine receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Compro, Prochlorperazine, Procomp (discontinued: Compazine, Prochlorperazine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Prochlorperazine maleate
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| compro | ANDA | 2024-11-20 |
| prochlorperazine | ANDA | 2023-11-29 |
| prochlorperazine edisylate | ANDA | 2024-12-19 |
| prochlorperazine maleate | ANDA | 2025-01-08 |
| prochlorperazine maleate prochlorperazine maleate | ANDA | 2024-11-21 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0780 | Injection, prochlorperazine, up to 10 mg |
| Q0164 | Prochlorperazine maleate, 5 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen |
| S0183 | Prochlorperazine maleate, oral, 5 mg (for circumstances falling under the medicare statute, use q0164) |
Clinical
Clinical Trials
54 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Prochlorperazine |
| INN | prochlorperazine |
| Description | Prochlorperazine is a member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. It has a role as an antiemetic, a dopaminergic antagonist, an alpha-adrenergic antagonist, a cholinergic antagonist, a first generation antipsychotic, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and a dopamine receptor D2 antagonist. It is an organochlorine compound, a N-alkylpiperazine, a N-methylpiperazine and a member of phenothiazines. It derives from a hydride of a 10H-phenothiazine. |
| Classification | Small molecule |
| Drug class | Typical antipsychotic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 58-38-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL728 |
| ChEBI ID | 8435 |
| PubChem CID | 4917 |
| DrugBank | DB00433 |
| UNII ID | YHP6YLT61T (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
S100A4
S100A4
Organism
Homo sapiens
Gene name
S100A4
Gene synonyms
CAPL, MTS1
NCBI Gene ID
Protein name
protein S100-A4
Protein synonyms
calcium placental protein, Calvasculin, fibroblast-specific protein-1, leukemia multidrug resistance associated protein, malignant transformation suppression 1, Metastasin, metastasin 1, murine placental homolog, Placental calcium-binding protein, Protein Mts1, S100 calcium-binding protein A4, S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
Uniprot ID
Mouse ortholog
S100a4 (20198)
protein S100-A4 (P20066)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
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Estimated US medical usage
Prochlorperazine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,284 documents
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Safety
Black-box Warning
Black-box warning for: Compro, Prochlorperazine, Prochlorperazine edisylate, Prochlorperazine maleate, Prochlorperazine maleate prochlorperazine maleate
Adverse Events
Top Adverse Reactions
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3,252 adverse events reported
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