PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
AboutPricing
Drug ReportsProcaine
Procaine
Achromycin, Novocain, Ravocaine Novocain W/, Tetracyn (procaine) is a small molecule pharmaceutical. Procaine was first approved as Procaine hydrochloride w/ epinephrine on 1982-01-01. It is used to treat pain and substance withdrawal syndrome in the USA. It is known to target ryanodine receptor 1 and ryanodine receptor 2.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
psychological phenomenaD011579
mental disordersD001523
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Procaine hydrochloride
+
Tetracycline hydrochloride
Tradename
Company
Number
Date
Products
ACHROMYCINLederle LaboratoriesN-050276 DISCN1982-01-01
2 products
Hide discontinued
Norepinephrine bitartrate
+
Procaine hydrochloride
+
Propoxycaine hydrochloride
Tradename
Company
Number
Date
Products
RAVOCAINE AND NOVOCAIN W/ LEVOPHEDEastman KodakN-008592 DISCN1982-01-01
1 products
Hide discontinued
Levonordefrin
+
Procaine hydrochloride
+
Propoxycaine hydrochloride
Tradename
Company
Number
Date
Products
RAVOCAINE AND NOVOCAIN W/ NEO-COBEFRINEastman KodakN-008592 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bicillin c-r 900/300New Drug Application2024-06-03
bicillin crNew Drug Application2024-06-04
novocain2007-04-16
novocaine2007-08-28
npag tattoo numbing creamC2002632025-02-21
tktx numbC2002632025-03-19
txtk numbC2002632025-03-14
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C05: Vasoprotectives
C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
C05AD05: Procaine
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01C: Beta-lactam antibacterials, penicillins
J01CE: Beta-lactamase sensitive penicillins
J01CE09: Procaine benzylpenicillin
N: Nervous system drugs
N01: Anesthetics
N01B: Local anesthetics
N01BA: Esters of aminobenzoic acid for local anesthesia
N01BA02: Procaine
N01BA52: Procaine, combinations
S: Sensory organ drugs
S01: Ophthalmologicals
S01H: Local anesthetics, ophthalmologic
S01HA: Local anesthetics
S01HA05: Procaine
HCPCS
Code
Description
J0558
Injection, penicillin g benzathine and penicillin g procaine, 100,000 units
J2401
Injection, chloroprocaine hydrochloride, per 1 mg
J2402
Injection, chloroprocaine hydrochloride (clorotekal), per 1 mg
J2510
Injection, penicillin g procaine, aqueous, up to 600,000 units
Clinical
Clinical Trials
72 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients11
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameProcaine
INNprocaine
Description
Procaine is a benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol. It has a role as a local anaesthetic, a central nervous system depressant, a peripheral nervous system drug and a drug allergen. It is a benzoate ester, a substituted aniline and a tertiary amino compound. It is functionally related to a 2-diethylaminoethanol and a 4-aminobenzoic acid. It is a conjugate base of a procaine(1+).
Classification
Small molecule
Drug classlocal anesthetics
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)CCOC(=O)c1ccc(N)cc1
Identifiers
PDB
CAS-ID59-46-1
RxCUI
ChEMBL IDCHEMBL569
ChEBI ID8430
PubChem CID4914
DrugBankDB00721
UNII ID4Z8Y51M438 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
RYR1
RYR1
RYR2
RYR2
Organism
Homo sapiens
Gene name
RYR1
Gene synonyms
RYDR
NCBI Gene ID
Protein name
ryanodine receptor 1
Protein synonyms
central core disease of muscle, protein phosphatase 1, regulatory subunit 137, ryanodine receptor 1 (skeletal), sarcoplasmic reticulum calcium release channel, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle-type ryanodine receptor, Type 1 ryanodine receptor, type 1-like ryanodine receptor
Uniprot ID
Mouse ortholog
Ryr1 (20190)
ryanodine receptor 1 (Q99JF9)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 15,854 documents
View more details
Safety
Black-box Warning
Black-box warning for: Bicillin c-r 900/300, Bicillin cr
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
1,075 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use