Probenecid
Orlynvah, Polycillin-prb, Probalan, Probampacin, Probenecid (probenecid) is a small molecule pharmaceutical. Probenecid was first approved as Principen w/ probenecid on 1982-01-01. It is used to treat gonorrhea, gout, and neurosyphilis in the USA. The pharmaceutical is active against solute carrier family 22 member 6. In addition, it is known to target solute carrier organic anion transporter family member 1C1 and transient receptor potential cation channel subfamily V member 2.
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Commercial
Trade Name
FDA
EMA
Probalan, Probenecid (discontinued: Benemid, Probenecid)
CombinationsCol-probenecid, Orlynvah, Probenecid colchicine (discontinued: Colbenemid, Polycillin-prb, Principen w/ probenecid, Probampacin, Proben-c, Probenecid colchicine, Probenecid w/ colchicine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Probenecid
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BENEMID | Merck & Co | N-007898 DISCN | 1982-01-01 | 1 products, RLD |
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Colchicine
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Probenecid
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COLBENEMID | Merck & Co | N-012383 DISCN | 1982-01-01 | 1 products, RLD |
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Ampicillin
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Ampicillin trihydrate
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Probenecid
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRINCIPEN W/ PROBENECID | Bristol Myers Squibb | N-050488 DISCN | 1982-01-01 | 1 products |
| POLYCILLIN-PRB | Bristol Myers Squibb | N-050457 DISCN | 1982-01-01 | 1 products |
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Probenecid
+
Sulopenem etzadroxil
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ORLYNVAH | Iterum Therapeutics | N-213972 RX | 2024-10-25 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| probalance hand sanitizer advanced | OTC monograph not final | 2020-05-20 |
| probenecid | ANDA | 2024-10-16 |
| probenecid and colchicine | ANDA | 2023-11-06 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
63 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 1 | — | 1 | 5 | 8 |
| Cytomegalovirus retinitis | D017726 | EFO_1001302 | — | 1 | 1 | — | 1 | 2 | 5 |
| Retinitis | D012173 | — | H30.9 | 1 | 1 | — | 1 | 2 | 5 |
| Drug interactions | D004347 | — | — | 3 | — | — | 1 | — | 4 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | — | — | — | 1 | — | 1 |
| Fontan procedure | D018729 | — | — | — | — | — | 1 | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | — | 3 | — | 1 | 6 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | 1 | — | 3 | — | 1 | 5 |
| Communicable diseases | D003141 | — | — | 2 | — | 2 | — | 1 | 5 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | 1 | — | — | 3 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | 1 | — | — | 2 |
| Intraabdominal infections | D059413 | — | — | 1 | — | 1 | — | — | 2 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | 1 | 1 | — | — | 2 |
| Heart failure | D006333 | HP_0001635 | I50 | — | 2 | 1 | — | — | 2 |
| Cystitis | D003556 | EFO_1000025 | N30 | 1 | — | 1 | — | — | 2 |
| Blood pressure | D001794 | EFO_0004325 | — | — | — | 1 | — | — | 1 |
Show 6 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial infections | D001424 | — | A49 | 1 | 1 | — | — | 1 | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | — | 1 |
| Prehypertension | D058246 | — | — | — | 1 | — | — | — | 1 |
| Hyperuricemia | D033461 | HP_0002149 | — | — | 1 | — | — | — | 1 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | 1 | — | — | — | 1 |
| Systolic murmurs | D054160 | — | R01.1 | — | 1 | — | — | — | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | 1 | 1 | — | — | — | 1 |
| Brain injuries | D001930 | — | S06.9 | 1 | 1 | — | — | — | 1 |
| Substance withdrawal syndrome | D013375 | EFO_0005800 | — | — | 1 | — | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | — | — | — | 1 |
Show 2 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 12 | — | — | — | — | 12 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 3 | — | — | — | — | 3 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | 1 | — | — | — | 1 | 2 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | — | — | — | — | 1 |
| Influenza in birds | D005585 | — | J09.X | 1 | — | — | — | — | 1 |
| Influenza a virus | D009980 | NCBITaxon_11320 | — | 1 | — | — | — | — | 1 |
| Hematopoietic stem cell transplantation | D018380 | — | — | 1 | — | — | — | — | 1 |
| Hemorrhagic cystitis | D000096722 | — | — | 1 | — | — | — | — | 1 |
| Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
Show 5 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sprains and strains | D013180 | — | — | — | — | — | — | 1 | 1 |
| Breast milk expression | D061186 | — | — | — | — | — | — | 1 | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 1 | 1 |
| Leukoencephalopathies | D056784 | HP_0002352 | — | — | — | — | — | 1 | 1 |
| Progressive multifocal leukoencephalopathy | D007968 | EFO_0007455 | A81.2 | — | — | — | — | 1 | 1 |
| Gout | D006073 | EFO_0004274 | M10 | — | — | — | — | 1 | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
| Abscess | D000038 | EFO_0003030 | — | — | — | — | — | 1 | 1 |
| Surgical wound | D000072836 | — | — | — | — | — | — | 1 | 1 |
| Peritonsillar abscess | D000039 | EFO_0007429 | J36 | — | — | — | — | 1 | 1 |
Show 3 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Probenecid |
| INN | probenecid |
| Description | Probenecid is a sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups. It has a role as a uricosuric drug. It is a sulfonamide and a member of benzoic acids. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCN(CCC)S(=O)(=O)c1ccc(C(=O)O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 57-66-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL897 |
| ChEBI ID | 8426 |
| PubChem CID | 4911 |
| DrugBank | DB01032 |
| UNII ID | PO572Z7917 (ChemIDplus, GSRS) |
Target
Agency Approved
SLC22A6
SLC22A6
Organism
Homo sapiens
Gene name
SLC22A6
Gene synonyms
OAT1, PAHT
NCBI Gene ID
Protein name
solute carrier family 22 member 6
Protein synonyms
hOAT1, hPAHT, hROAT1, Organic anion transporter 1, PAH transporter, para-aminohippurate transporter, Renal organic anion transporter 1, solute carrier family 22 (organic anion transporter), member 6
Uniprot ID
Mouse ortholog
Slc22a6 (18399)
solute carrier family 22 member 6 (Q8VC69)
Alternate
SLCO1C1
SLCO1C1
TRPV2
TRPV2
Organism
Homo sapiens
Gene name
SLCO1C1
Gene synonyms
OATP14, OATP1C1, OATPF, SLC21A14
NCBI Gene ID
Protein name
solute carrier organic anion transporter family member 1C1
Protein synonyms
OAT-RP-5, OATP-14, OATP-F, OATP-RP5, OATP1C1, Organic anion transporter 1C1, Organic anion transporter F, Organic anion transporter polypeptide-related protein 5, organic anion transporting polypeptide 14, Organic anion-transporting polypeptide 14, solute carrier family 21 (organic anion transporter), member 14, Solute carrier family 21 member 14, Thyroxine transporter
Uniprot ID
Mouse ortholog
Slco1c1 (58807)
solute carrier organic anion transporter family member 1C1 (Q9ERB5)
Variants
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Financial
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Estimated US medical usage
Probenecid
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Colchicine
Total medical expenditures per year (USD, in millions)
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Probenecid
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Trends
PubMed Central
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Safety
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Adverse Events
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261 adverse events reported
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