Primaquine
Primaquine (primaquine) is a small molecule pharmaceutical. Primaquine was first approved as Aralen phosphate w/ primaquine phosphate on 1982-01-01. It is used to treat falciparum malaria, malaria, and vivax malaria in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| primaquine phosphate | ANDA | 2024-08-13 |
Indications
FDA
EMA
Agency Specific
FDA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
130 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | 11 | 22 | 24 | 27 | 26 | 101 |
| Vivax malaria | D016780 | EFO_0007445 | B51 | 3 | 9 | 15 | 11 | 17 | 52 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | 1 | 12 | 7 | 10 | 10 | 37 |
| Glucosephosphate dehydrogenase deficiency | D005955 | EFO_0007287 | — | 3 | 1 | — | 2 | 5 | 11 |
| Recurrence | D012008 | — | — | — | 1 | 1 | 1 | 6 | 8 |
| Infections | D007239 | EFO_0000544 | — | 1 | 1 | 1 | 2 | — | 5 |
| Pneumonia | D011014 | EFO_0003106 | — | — | — | 1 | 1 | 1 | 3 |
| Pneumocystis pneumonia | D011020 | EFO_0007448 | B59 | — | — | 1 | 1 | 1 | 3 |
| Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | — | 1 | — | 1 |
| Communicable diseases | D003141 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parasitemia | D018512 | — | — | — | — | 1 | — | 1 | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | 1 | — | 1 | 2 |
| Asymptomatic diseases | D058070 | — | — | — | 1 | 2 | — | — | 2 |
| Covid-19 | D000086382 | — | — | — | 1 | 1 | — | — | 1 |
| Therapeutics | D013812 | — | — | — | — | 1 | — | — | 1 |
| Hemolysis | D006461 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | 1 | — | — | — | 7 |
| Pharmacokinetics | D010599 | — | — | 3 | 1 | — | — | — | 3 |
| Combination drug therapy | D004359 | — | — | 2 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Favism | D005236 | — | D55.0 | — | — | — | — | 1 | 1 |
| Mass drug administration | D000074381 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Primaquine |
| INN | primaquine |
| Description | Primaquine is an N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia. It has a role as an antimalarial. It is an aminoquinoline, a N-substituted diamine and an aromatic ether. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc(NC(C)CCCN)c2ncccc2c1 |
Identifiers
| PDB | — |
| CAS-ID | 90-34-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL506 |
| ChEBI ID | 8405 |
| PubChem CID | 4908 |
| DrugBank | DB01087 |
| UNII ID | MVR3634GX1 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Primaquine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 7,562 documents
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Safety
Black-box Warning
Black-box warning for: Primaquine phosphate
Adverse Events
Top Adverse Reactions
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256 adverse events reported
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