Citanest, Fortacin(prilocaine)
/ Prilocaine, Citanest, Fortacin, Oraqix, Prilocaine (prilocaine) is a small molecule pharmaceutical. Prilocaine was first approved as Citanest forte on 1982-01-01. It is used to treat pain in the USA. It has been approved in Europe to treat physiological sexual dysfunction and premature ejaculation.
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Commercial
Trade Name
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Prilocaine (discontinued: Citanest)
CombinationsCitanest, Lidocaine prilocaine, Oraqix, Prilocaine epinephrine (discontinued: Citanest, Emla, Lidocaine prilocaine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lidocaine
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Prilocaine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ORAQIX | Dentsply Pharmaceutical | N-021451 RX | 2003-12-19 | 1 products, RLD, RS |
Show 2 discontinued
Prilocaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CITANEST | AstraZeneca | N-014763 DISCN | 1982-01-01 | 3 products, RLD |
| CITANEST PLAIN | AstraZeneca | N-014763 DISCN | 1982-01-01 | 1 products, RLD |
| CITANEST PLAIN DENTAL | Dentsply Pharmaceutical | N-021382 DISCN | 1982-01-01 | 1 products, RLD |
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Epinephrine bitartrate
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Prilocaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CITANEST FORTE DENTAL | Dentsply Pharmaceutical | N-021383 RX | 1982-01-01 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| agoneaze | unapproved drug other | 2018-04-18 |
| anodyne lpt | NDA authorized generic | 2017-03-17 |
| cadira compliant blood stat | unapproved drug other | 2018-11-01 |
| citanest forte | New Drug Application | 2017-10-17 |
| citanest forte citanest plain | New Drug Application | 2010-04-26 |
| citanest forte dental | ANDA | 2024-02-29 |
| citanest plain | ANDA | 2021-11-10 |
| dermacinrx prikaan | NDA authorized generic | 2016-09-19 |
| dibucaine hcl 0.5% / lidocaine 15% / phenylephrine hcl 1% / prilocaine 5% | unapproved drug other | 2019-05-10 |
| inflammation reduction pack | ANDA | 2015-11-18 |
Show 24 more
Indications
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Agency Specific
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253 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 2 | 4 | 6 | 6 | 11 | 28 |
| Postoperative pain | D010149 | — | G89.18 | 1 | — | — | 3 | 6 | 10 |
| Healthy volunteers/patients | — | — | — | 5 | — | — | 1 | 4 | 10 |
| Local anesthesia | D000772 | — | — | 1 | 2 | 2 | 2 | 4 | 10 |
| Spinal anesthesia | D000775 | — | — | 1 | — | — | 1 | 5 | 7 |
| Anesthesia | D000758 | — | — | 1 | — | — | 2 | 4 | 7 |
| Analgesia | D000698 | — | — | — | — | 1 | 1 | 4 | 6 |
| Brachial plexus block | D065527 | — | — | — | — | — | 3 | 2 | 5 |
| Contraception | D003267 | — | — | — | — | 3 | 2 | — | 5 |
| Actinic keratosis | D055623 | — | L57.0 | 3 | — | — | 1 | 1 | 5 |
Show 43 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Procedural pain | D000073818 | — | — | — | — | 1 | — | 4 | 5 |
| Premature ejaculation | D061686 | HP_0012876 | F52.4 | 2 | 2 | 2 | — | — | 5 |
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | 2 | 2 | — | — | 4 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | 1 | — | 1 | 2 |
| Atrophy | D001284 | — | — | — | 1 | 1 | — | 1 | 2 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34.0 | — | — | 1 | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | 1 | — | — | 1 |
| Raynaud disease | D011928 | EFO_1001145 | I73.0 | — | — | 1 | — | — | 1 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | — | — | 1 | — | — | 1 |
| Sclerosis | D012598 | — | — | — | — | 1 | — | — | 1 |
Show 11 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuralgia | D009437 | EFO_0009430 | — | — | 3 | — | — | 2 | 5 |
| Wounds and injuries | D014947 | — | T14.8 | — | 2 | — | — | 1 | 3 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | 1 | — | — | 2 | 3 |
| Headache | D006261 | HP_0002315 | R51 | 1 | 1 | — | — | 2 | 3 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | 2 | 3 |
| Back pain | D001416 | HP_0003418 | M54 | — | 1 | — | — | 1 | 2 |
| Cesarean section | D002585 | — | — | — | 1 | — | — | 1 | 2 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 1 | 1 | — | — | 1 | 2 |
| Carcinoma | D002277 | — | C80.0 | 1 | 1 | — | — | — | 2 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | — | — | 1 | 2 |
Show 21 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Skin diseases | D012871 | — | L00-L99 | 2 | — | — | — | — | 2 |
| Mouth diseases | D009059 | EFO_1001047 | K13 | 2 | — | — | — | — | 2 |
| Bowen's disease | D001913 | — | D00-D09 | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | 1 | — | — | — | — | 1 |
| Compartment syndromes | D003161 | — | T79.A0 | 1 | — | — | — | — | 1 |
| Topical administration | D000287 | — | — | 1 | — | — | — | — | 1 |
| Dental anesthesia | D000766 | — | — | 1 | — | — | — | — | 1 |
| Hidradenitis suppurativa | D017497 | — | L73.2 | 1 | — | — | — | — | 1 |
| Hidradenitis | D016575 | — | — | 1 | — | — | — | — | 1 |
| Traumatic dental occlusion | D003769 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Radiculopathy | D011843 | — | M54.1 | — | — | — | — | 5 | 5 |
| Intervertebral disc displacement | D007405 | EFO_1001800 | — | — | — | — | — | 5 | 5 |
| Pruritus | D011537 | HP_0000989 | L29 | — | — | — | — | 3 | 3 |
| Neck pain | D019547 | HP_0030833 | M54.2 | — | — | — | — | 3 | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 2 | 2 |
| Ambulatory surgical procedures | D000556 | — | — | — | — | — | — | 2 | 2 |
| Urinary incontinence | D014549 | HP_0000020 | R32 | — | — | — | — | 2 | 2 |
| Stress urinary incontinence | D014550 | HP_0010992 | — | — | — | — | — | 2 | 2 |
| Carotid stenosis | D016893 | — | — | — | — | — | — | 2 | 2 |
| Chronic pain | D059350 | HP_0012532 | — | — | — | — | — | 2 | 2 |
Show 88 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Prilocaine |
| INN | prilocaine |
| Description | Prilocaine is an amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic. It has a role as a local anaesthetic and an anticonvulsant. It is an amino acid amide and a monocarboxylic acid amide. |
| Classification | Small molecule |
| Drug class | local anesthetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCNC(C)C(=O)Nc1ccccc1C |
Identifiers
| PDB | — |
| CAS-ID | 721-50-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1194 |
| ChEBI ID | 8404 |
| PubChem CID | 4906 |
| DrugBank | DB00750 |
| UNII ID | 046O35D44R (ChemIDplus, GSRS) |
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Prilocaine
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Lidocaine
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Prilocaine
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Safety
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888 adverse events reported
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