Preladenant
Preladenant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target adenosine receptor A2a, adenosine receptor A3, adenosine receptor A2b, and adenosine receptor A1.
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Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | 3 | 4 | — | — | 9 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Movement disorders | D009069 | HP_0100022 | — | — | 3 | — | — | — | 3 |
| Central nervous system diseases | D002493 | HP_0002011 | G96.9 | — | 2 | — | — | — | 2 |
| Brain diseases | D001927 | HP_0001298 | G93.40 | — | 2 | — | — | — | 2 |
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | 2 | — | — | — | 2 |
| Drug-induced akathisia | D017109 | EFO_1000903 | G25.71 | — | 2 | — | — | — | 2 |
| Parkinsonian disorders | D020734 | HP_0001300 | G20.C | — | 1 | — | — | — | 1 |
| Drug-induced dyskinesia | D004409 | EFO_1000904 | — | — | 1 | — | — | — | 1 |
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Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Preladenant |
| INN | preladenant |
| Description | Preladenant (SCH 420814) was a drug that was developed by Schering-Plough which acted as a potent and selective antagonist at the adenosine A2A receptor. It was being researched as a potential treatment for Parkinson's disease. Positive results were reported in Phase II clinical trials in humans, but it did not prove itself to be more effective than a placebo during Phase III trials, and so was discontinued in May 2013.
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| Classification | Small molecule |
| Drug class | adenosine receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COCCOc1ccc(N2CCN(CCn3ncc4c3nc(N)n3nc(-c5ccco5)nc43)CC2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 377727-87-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL240624 |
| ChEBI ID | — |
| PubChem CID | 10117987 |
| DrugBank | — |
| UNII ID | 950O97NUPO (ChemIDplus, GSRS) |
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