Prazosin
Minipress, Minizide, Prazosin (prazosin) is a small molecule pharmaceutical. Prazosin was first approved as Minizide on 1982-01-01. It is used to treat hypertension, prostatic hyperplasia, raynaud disease, and urinary retention in the USA. The pharmaceutical is active against alpha-1A adrenergic receptor, alpha-1B adrenergic receptor, and alpha-1D adrenergic receptor. In addition, it is known to target alpha-2B adrenergic receptor, alpha-2A adrenergic receptor, and alpha-2C adrenergic receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Minipress, Prazosin (discontinued: Minipress, Prazosin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| prazosin | ANDA | 2023-09-15 |
| prazosin hcl | ANDA | 2024-09-13 |
| prazosin hydrochloride | ANDA | 2025-01-08 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02C: Antiadrenergic agents, peripherally acting
— C02CA: Alpha-adrenoreceptor antagonists, peripherally acting
— C02CA01: Prazosin
— C02L: Antihypertensives and diuretics in combination
— C02LE: Alpha-adrenoreceptor antagonists and diuretics
— C02LE01: Prazosin and diuretics
HCPCS
No data
Clinical
Clinical Trials
82 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 2 | 5 | 3 | 5 | 10 | 25 |
| Traumatic stress disorders | D040921 | — | — | 2 | 5 | 1 | 4 | 7 | 19 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 5 | 7 | 1 | 1 | 4 | 15 |
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | 1 | — | 3 | 4 | 10 |
| Parasomnias | D020447 | — | G47.5 | — | 1 | — | 1 | 2 | 4 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | — | — | — | 1 | 2 | 3 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | — | — | 1 | 2 | 3 |
| Dyssomnias | D020920 | — | — | — | 1 | — | 1 | 1 | 3 |
| Fibrosis | D005355 | — | — | — | 1 | — | 1 | — | 2 |
| Suicidal ideation | D059020 | EFO_0004320 | R45.851 | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleep wake disorders | D012893 | — | G47 | — | — | 1 | — | 3 | 4 |
| Scorpion stings | D065008 | — | — | — | — | 1 | — | 1 | 2 |
| Poisoning | D011041 | EFO_0008546 | T65.91 | — | — | 1 | — | — | 1 |
| Nephrolithiasis | D053040 | — | N20.0 | — | — | 1 | — | — | 1 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | 1 | — | — | 1 |
| Ureteral calculi | D014514 | — | — | — | — | 1 | — | — | 1 |
| Calculi | D002137 | — | — | — | — | 1 | — | — | 1 |
| Ureterolithiasis | D053039 | EFO_1001228 | N20.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcohol drinking | D000428 | EFO_0004329 | — | — | 2 | — | — | 2 | 4 |
| Combat disorders | D003130 | — | — | 1 | 2 | — | — | 2 | 4 |
| Brain injuries | D001930 | — | S06.9 | 2 | 1 | — | — | 1 | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | 2 | 3 |
| Covid-19 | D000086382 | — | — | — | 1 | — | — | 1 | 2 |
| Pheochromocytoma | D010673 | — | — | — | 1 | — | — | 1 | 2 |
| Psychomotor agitation | D011595 | — | — | — | 1 | — | — | 1 | 2 |
| Traumatic brain injuries | D000070642 | — | S06 | 2 | 1 | — | — | — | 2 |
| Brain concussion | D001924 | — | S06.0 | 2 | 1 | — | — | — | 2 |
| Magnetic resonance imaging | D008279 | — | — | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | — | — | — | 1 | 2 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | 1 | 2 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Cigarette smoking | D000073865 | — | — | 1 | — | — | — | — | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | — | — | — | — | 1 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | 1 | — | — | — | — | 1 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 2 | 2 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 2 | 2 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | — | — | — | — | 2 | 2 |
| Adrenocortical adenoma | D018246 | — | — | — | — | — | — | 1 | 1 |
| Adrenal gland neoplasms | D000310 | EFO_0003850 | C74 | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | — | — | — | 1 | 1 |
| Chronic disease | D002908 | — | — | — | — | — | — | 1 | 1 |
| Alcohol-related disorders | D019973 | — | F10 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Prazosin |
| INN | prazosin |
| Description | Prazosin is a member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively. It has a role as an antihypertensive agent, an alpha-adrenergic antagonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is a member of piperazines, a member of quinazolines, a member of furans, a monocarboxylic acid amide and an aromatic ether. |
| Classification | Small molecule |
| Drug class | antihypertensives (prazosin type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC |
Identifiers
| PDB | — |
| CAS-ID | 19216-56-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2 |
| ChEBI ID | 8364 |
| PubChem CID | 4893 |
| DrugBank | DB00457 |
| UNII ID | XM03YJ541D (ChemIDplus, GSRS) |
Target
Agency Approved
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (P97714)
Alternate
NQO2
NQO2
Organism
Homo sapiens
Gene name
NQO2
Gene synonyms
NMOR2
NCBI Gene ID
Protein name
ribosyldihydronicotinamide dehydrogenase [quinone]
Protein synonyms
N-ribosyldihydronicotinamide:quinone reductase 2, NAD(P)H dehydrogenase, quinone 2, NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2, NAD(P)H quinone dehydrogenase 2, NRH dehydrogenase [quinone] 2, NRH:quinone oxidoreductase 2, QR2, Quinone reductase 2, ribosyldihydronicotinamide dehydrogenase
Uniprot ID
Mouse ortholog
Nqo2 (18105)
ribosyldihydronicotinamide dehydrogenase [quinone] (Q9JI75)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Prazosin
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Polythiazide
Total medical expenditures per year (USD, in millions)
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Prazosin
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,847 adverse events reported
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