Praziquantel
Praziquantel (praziquantel) is a small molecule pharmaceutical. Praziquantel was first approved as Biltricide on 1982-12-29. It is used to treat clonorchiasis, cysticercosis, helminthiasis, opisthorchiasis, and parasitic intestinal diseases amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| digestive system diseases | D004066 |
Trade Name
FDA
EMA
Praziquantel (discontinued: Biltricide)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| biltricide | New Drug Application | 2023-12-06 |
| praziquantel | ANDA | 2024-02-28 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
55 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schistosomiasis | D012552 | EFO_1001475 | B65 | 1 | 7 | 9 | 4 | 10 | 30 |
| Malaria | D008288 | EFO_0001068 | B54 | — | — | — | 1 | 5 | 6 |
| Schistosomiasis mansoni | D012555 | EFO_1001420 | B65.1 | — | 2 | 1 | 2 | 1 | 6 |
| Taeniasis | D013622 | EFO_1001433 | B68 | — | 2 | 3 | 1 | 1 | 5 |
| Helminthiasis | D006373 | EFO_1001342 | B65-B83 | — | — | — | 1 | 3 | 4 |
| Neurocysticercosis | D020019 | — | — | — | 2 | 3 | 1 | — | 4 |
| Cysticercosis | D003551 | EFO_0007231 | B69 | — | 2 | 3 | 1 | — | 4 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | — | — | 1 | 2 | 3 |
| Hiv | D006678 | — | — | — | — | — | 1 | — | 1 |
| Disease susceptibility | D004198 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schistosomiasis haematobia | D012553 | EFO_0007530 | B65.0 | — | — | 5 | — | 3 | 8 |
| Healthy volunteers/patients | — | — | — | 5 | — | 1 | — | — | 6 |
| Schistosoma haematobium | D012548 | — | — | — | 1 | 3 | — | 1 | 4 |
| Schistosoma mansoni | D012550 | NCBITaxon_6183 | — | — | 1 | 3 | — | 1 | 4 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | 1 | — | — | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | 1 | — | — | 1 |
| Recurrence | D012008 | — | — | — | — | 1 | — | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Schistosomiasis japonica | D012554 | EFO_1001419 | B65.2 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Filariasis | D005368 | — | B74 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 6 | 6 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 4 | 4 |
| Communicable diseases | D003141 | — | — | — | — | — | — | 3 | 3 |
| Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | — | — | 3 | 3 |
| Coinfection | D060085 | — | — | — | — | — | — | 3 | 3 |
| Sexually transmitted diseases | D012749 | — | A50-A64 | — | — | — | — | 1 | 1 |
| Schistosoma | D012547 | — | — | — | — | — | — | 1 | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | — | 1 | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 1 | 1 |
| Immunologic deficiency syndromes | D007153 | HP_0002721 | D84.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Praziquantel |
| INN | praziquantel |
| Description | 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one is a member of isoquinolines. |
| Classification | Small molecule |
| Drug class | anthelmintics (undefined group): 2-deoxoparaherquamide A derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(C1CCCCC1)N1CC(=O)N2CCc3ccccc3C2C1 |
Identifiers
| PDB | — |
| CAS-ID | 55268-74-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL976 |
| ChEBI ID | — |
| PubChem CID | 4891 |
| DrugBank | DB01058 |
| UNII ID | 6490C9U457 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Praziquantel
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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190 adverse events reported
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