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Drug ReportsPramoxine
Pramoxine
Epifoam, Pramosone, Proctofoam (pramoxine) is a small molecule pharmaceutical. Pramoxine was first approved as Pramosone on 1982-01-01. It is used to treat contact dermatitis, fissure in ano, hemorrhoids, pain, and pruritus in the USA.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
cardiovascular diseasesD002318
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Combinations
Epifoam, Pramosone, Proctofoam (discontinued: Hydrocortisone pramoxine, Pramosone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
analpram hcunapproved drug other2024-11-11
anesthetic hemorrhoidalOTC monograph not final2020-07-23
anti itchC2002632025-01-15
anti itch soothing 1 pramoxine hydrochlorideC2002632024-08-01
anti-itchOTC monograph not final2016-07-01
anti-itch soothing wipes 1 pramoxine hydrochlorideC2002632024-08-01
antibioticC2002632024-10-14
antibiotic and pain reliefC2002632024-10-14
antibiotic plus pain reliefC2002632024-11-01
antibiotic, pain and scarC2002632024-11-05
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Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C05: Vasoprotectives
C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
C05AD07: Pramocaine
D: Dermatologicals
D04: Antipruritics, incl. antihistamines, anesthetics, etc.
D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
D04AB: Anesthetics for topical use
D04AB07: Pramocaine
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PruritusD011537L29112
Indications Phases 3
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HemorrhoidsD006484EFO_0009552K6411
PregnancyD011247EFO_0002950Z33.111
IchthyosisD007057E50.811
MyalgiaD063806M79.111
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePramoxine
INNpramocaine
Description
Pramocaine is a member of the class of morpholines that is morpholine substituted at the nitrogen atom by a 3-(4-butoxyphenoxy)propyl group. It has a role as a local anaesthetic. It is a member of morpholines and an aromatic ether.
Classification
Small molecule
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCCCOc1ccc(OCCCN2CCOCC2)cc1
Identifiers
PDB
CAS-ID140-65-8
RxCUI
ChEMBL IDCHEMBL1198
ChEBI ID8357
PubChem CID4886
DrugBankDB09345
UNII ID068X84E056 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
No data
Estimated US medical usage
Pramoxine
+
Bacitracin
+
Polymyxin b
Total medical expenditures per year (USD, in millions)
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Pramoxine
+
Calamine
Total medical expenditures per year (USD, in millions)
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Pramoxine
+
Hydrocortisone
Total medical expenditures per year (USD, in millions)
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Pramoxine
+
Neomycin
+
Polymyxin b
Total medical expenditures per year (USD, in millions)
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Pramoxine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 226 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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670 adverse events reported
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