Pramoxine
Epifoam, Pramosone, Proctofoam (pramoxine) is a small molecule pharmaceutical. Pramoxine was first approved as Pramosone on 1982-01-01. It is used to treat contact dermatitis, fissure in ano, hemorrhoids, pain, and pruritus in the USA.
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Commercial
Trade Name
FDA
EMA
Combinations
Epifoam, Pramosone, Proctofoam (discontinued: Hydrocortisone pramoxine, Pramosone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| analpram hc | unapproved drug other | 2024-11-11 |
| anesthetic hemorrhoidal | OTC monograph not final | 2020-07-23 |
| anti itch | C200263 | 2025-01-15 |
| anti itch soothing 1 pramoxine hydrochloride | C200263 | 2024-08-01 |
| anti-itch | OTC monograph not final | 2016-07-01 |
| anti-itch soothing wipes 1 pramoxine hydrochloride | C200263 | 2024-08-01 |
| antibiotic | C200263 | 2024-10-14 |
| antibiotic and pain relief | C200263 | 2024-10-14 |
| antibiotic plus pain relief | C200263 | 2024-11-01 |
| antibiotic, pain and scar | C200263 | 2024-11-05 |
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Indications
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Agency Specific
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Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
— C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
— C05AD07: Pramocaine
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AB: Anesthetics for topical use
— D04AB07: Pramocaine
HCPCS
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Essential tremor | D020329 | EFO_0003108 | G25.0 | — | 3 | — | — | — | 3 |
| Tremor | D014202 | — | R25.1 | — | 3 | — | — | — | 3 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | — | — | — | 1 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 1 | — | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 1 | — | — | — | 1 |
| Traumatic stress disorders | D040921 | — | — | — | 1 | — | — | — | 1 |
| Trauma and stressor related disorders | D000068099 | — | F43.9 | — | 1 | — | — | — | 1 |
| Brain diseases | D001927 | — | G93.40 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhoids | D006484 | EFO_0009552 | K64 | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Ichthyosis | D007057 | — | E50.8 | — | — | — | — | 1 | 1 |
| Myalgia | D063806 | — | M79.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pramoxine |
| INN | pramocaine |
| Description | Pramocaine is a member of the class of morpholines that is morpholine substituted at the nitrogen atom by a 3-(4-butoxyphenoxy)propyl group. It has a role as a local anaesthetic. It is a member of morpholines and an aromatic ether. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCOc1ccc(OCCCN2CCOCC2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 140-65-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1198 |
| ChEBI ID | 8357 |
| PubChem CID | 4886 |
| DrugBank | DB09345 |
| UNII ID | 068X84E056 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
Revenue by drug
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Estimated US medical usage
Pramoxine
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Bacitracin
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Polymyxin b
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Pramoxine
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Calamine
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Pramoxine
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Hydrocortisone
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Pramoxine
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Neomycin
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Polymyxin b
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Pramoxine
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Trends
PubMed Central
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Additional graphs summarizing 227 documents
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Safety
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670 adverse events reported
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