Pramoxine
Epifoam, Pramosone, Proctofoam (pramoxine) is a small molecule pharmaceutical. Pramoxine was first approved as Pramosone on 1982-01-01. It is used to treat contact dermatitis, fissure in ano, hemorrhoids, pain, and pruritus in the USA.
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Commercial
Trade Name
FDA
EMA
Combinations
Epifoam, Pramosone, Proctofoam (discontinued: Hydrocortisone pramoxine, Pramosone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| analpram hc | unapproved drug other | 2022-12-20 |
| anesthetic hemorrhoidal | OTC monograph not final | 2020-07-23 |
| anti itch | OTC monograph not final | 2017-11-28 |
| anti itch soothing 1 pramoxine hydrochloride | C200263 | 2024-08-01 |
| anti-itch | OTC monograph not final | 2016-07-01 |
| anti-itch soothing wipes 1 pramoxine hydrochloride | C200263 | 2024-08-01 |
| antibiotic | C200263 | 2024-10-14 |
| antibiotic and pain relief | C200263 | 2024-10-14 |
| antibiotic plus pain relief | C200263 | 2024-10-21 |
| antibiotic, pain and scar | C200263 | 2024-11-05 |
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Indications
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EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
— C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
— C05AD07: Pramocaine
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AB: Anesthetics for topical use
— D04AB07: Pramocaine
HCPCS
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Clinical
Clinical Trials
1314 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 35 | 49 | 23 | 3 | 6 | 99 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 26 | 41 | 19 | 3 | 4 | 79 |
| Lymphoid leukemia | D007945 | — | C91 | 22 | 36 | 18 | 3 | 4 | 70 |
| Adrenal insufficiency | D000309 | — | — | 6 | 6 | 7 | 17 | 34 | 69 |
| Syndrome | D013577 | — | — | 7 | 10 | 12 | 4 | 35 | 67 |
| Lymphoma | D008223 | — | C85.9 | 14 | 28 | 10 | 2 | 2 | 48 |
| Septic shock | D012772 | — | A48.3 | 1 | 10 | 16 | 8 | 15 | 46 |
| Cushing syndrome | D003480 | EFO_0003099 | E24 | — | 6 | 5 | 1 | 31 | 43 |
| Shock | D012769 | — | R57.1 | 1 | 8 | 15 | 10 | 10 | 41 |
| Healthy volunteers/patients | — | — | — | 9 | 2 | 1 | 9 | 17 | 38 |
Show 146 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | — | 8 | 7 | — | 22 | 37 |
| Prostatic neoplasms | D011471 | — | C61 | 4 | 14 | 7 | — | 5 | 28 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 11 | 15 | 4 | — | 2 | 26 |
| Premature birth | D047928 | EFO_0003917 | O60 | 3 | 1 | 1 | — | 19 | 24 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 14 | 9 | 3 | — | — | 23 |
| Covid-19 | D000086382 | — | — | — | — | 5 | — | 14 | 19 |
| Physiological stress | D013312 | — | — | — | — | 1 | — | 18 | 19 |
| Myeloid leukemia | D007951 | — | C92 | 11 | 7 | 2 | — | — | 17 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 3 | 2 | — | 12 | 16 |
| Hyperaldosteronism | D006929 | HP_0011736 | E26 | — | — | 1 | — | 14 | 15 |
Show 97 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 10 | 10 | — | — | 3 | 17 |
| Adrenal gland neoplasms | D000310 | EFO_0003850 | C74 | — | 2 | — | — | 12 | 14 |
| Neoplasms | D009369 | — | C80 | 3 | 7 | — | — | 4 | 13 |
| Hematologic neoplasms | D019337 | — | — | 7 | 8 | — | — | 1 | 12 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 1 | 4 | — | — | 5 | 9 |
| Anorexia | D000855 | HP_0002039 | R63.0 | — | 1 | — | — | 7 | 8 |
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | — | 1 | — | — | 7 | 8 |
| Overweight | D050177 | — | E66.3 | 3 | 1 | — | — | 5 | 8 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | — | — | 7 | 8 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | — | — | 7 | 8 |
Show 118 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcohol drinking | D000428 | EFO_0004329 | — | 3 | — | — | — | 6 | 9 |
| Blood pressure | D001794 | EFO_0004325 | — | 2 | — | — | — | 3 | 5 |
| Chronic pain | D059350 | HP_0012532 | — | 1 | — | — | — | 3 | 4 |
| Cocaine-related disorders | D019970 | — | F14 | 1 | — | — | — | 3 | 4 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | 1 | — | — | — | 3 | 4 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | 1 | — | — | — | 3 | 4 |
| Adrenal gland diseases | D000307 | HP_0000834 | E27.9 | 1 | — | — | — | 2 | 3 |
| Laron syndrome | D046150 | Orphanet_633 | E34.321 | 1 | — | — | — | 2 | 3 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | 2 | 3 |
| Problem behavior | D000066553 | — | — | 1 | — | — | — | 2 | 3 |
Show 48 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psychological distress | D000079225 | — | — | — | — | — | — | 7 | 7 |
| Dental implants | D015921 | — | — | — | — | — | — | 7 | 7 |
| Psychological burnout | D000077062 | — | — | — | — | — | — | 6 | 6 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | — | — | — | 6 | 6 |
| Stress fractures | D015775 | — | M84.3 | — | — | — | — | 6 | 6 |
| Nursing care | D009732 | — | — | — | — | — | — | 6 | 6 |
| Occupational stress | D000073397 | — | — | — | — | — | — | 6 | 6 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 5 | 5 |
| Infertility | D007246 | HP_0000789 | — | — | — | — | — | 5 | 5 |
| Professional burnout | D002055 | — | — | — | — | — | — | 5 | 5 |
Show 332 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pramoxine |
| INN | pramocaine |
| Description | Pramocaine is a member of the class of morpholines that is morpholine substituted at the nitrogen atom by a 3-(4-butoxyphenoxy)propyl group. It has a role as a local anaesthetic. It is a member of morpholines and an aromatic ether. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCOc1ccc(OCCCN2CCOCC2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 140-65-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1198 |
| ChEBI ID | 8357 |
| PubChem CID | 4886 |
| DrugBank | DB09345 |
| UNII ID | 068X84E056 (ChemIDplus, GSRS) |
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Pramoxine
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Bacitracin
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Polymyxin b
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Pramoxine
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Calamine
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Pramoxine
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Hydrocortisone
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Pramoxine
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Neomycin
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Polymyxin b
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Pramoxine
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Trends
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Safety
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637 adverse events reported
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