Pracinostat
Pracinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against polyamine deacetylase HDAC10. In addition, it is known to target histone deacetylase 1, histone deacetylase 5, and histone deacetylase 3.
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Commercial
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Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 2 | 1 | 1 | — | — | 4 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 1 | 1 | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 1 | 1 | — | — | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | 3 | — | — | — | 4 |
| Preleukemia | D011289 | — | — | 1 | 3 | — | — | — | 4 |
| Syndrome | D013577 | — | — | — | 3 | — | — | — | 3 |
| Myeloproliferative disorders | D009196 | — | D47.1 | — | 2 | — | — | — | 2 |
| Primary myelofibrosis | D055728 | — | D47.4 | — | 2 | — | — | — | 2 |
| Polycythemia vera | D011087 | — | D45 | — | 1 | — | — | — | 1 |
| Polycythemia | D011086 | EFO_0005804 | D75.1 | — | 1 | — | — | — | 1 |
| Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pracinostat |
| INN | pracinostat |
| Description | Pracinostat is a hydroxamic acid that is N-hydroxyacrylamide which is substituted at position 3 by a 2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl group (the E isomer). An orally available pan-histone deacetylase inhibitor with demonstrated activity in the treatment of advanced solid tumours. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor, an antineoplastic agent, an apoptosis inducer and an antimalarial. It is an olefinic compound, a hydroxamic acid, a benzimidazole and a tertiary amino compound. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: histone deacetylase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCc1nc2cc(/C=C/C(=O)NO)ccc2n1CCN(CC)CC |
Identifiers
| PDB | — |
| CAS-ID | 929016-96-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1851943 |
| ChEBI ID | — |
| PubChem CID | 49855250 |
| DrugBank | DB05223 |
| UNII ID | GPO2JN4UON (ChemIDplus, GSRS) |
Target
Alternate
HDAC1
HDAC1
HDAC5
HDAC5
HDAC3
HDAC3
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Safety
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24 adverse events reported
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