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Drug ReportsPosaconazole
Noxafil(posaconazole)
Noxafil, Posaconazole (posaconazole) is a small molecule pharmaceutical. Posaconazole was first approved as Noxafil on 2005-10-25. It is used to treat mycoses and oral candidiasis in the USA. It has been approved in Europe to treat aspergillosis, candidiasis, coccidioidomycosis, and mycoses.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
stomatognathic diseasesD009057
Trade Name
FDA
EMA
Noxafil, Posaconazole (discontinued: Noxafil, Posaconazole)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Posaconazole
Tradename
Company
Number
Date
Products
NOXAFILMerck & CoN-205596 RX2014-03-13
1 products, RLD, RS
NOXAFIL POWDERMIX KITMerck & CoN-214770 RX2021-05-31
1 products, RLD, RS
NOXAFILMerck & CoN-022003 RX2006-09-15
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
noxafilNew Drug Application2024-10-25
posaconazoleANDA2025-06-27
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration
Code
POSACONAZOLE, NOXAFIL, MERCK SHARP DOHME
2028-06-17ODE-355
2024-06-17I-881
2024-05-31NPP
POSACONAZOLE, NOXAFIL POWDERMIX KIT, MSD MERCK CO
2024-05-31NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Posaconazole, Noxafil, Merck Sharp Dohme
94935822033-02-27DP
90237902031-07-04DPU-1698, U-3160, U-3171
93582972031-06-24DPU-3160, U-3171
84100772029-03-13DP
97508222029-03-13DP
101179512029-03-13DP
ATC Codes
J: Antiinfectives for systemic use
J02: Antimycotics for systemic use
J02A: Antimycotics for systemic use
J02AC: Triazole and tetrazole derivatives
J02AC04: Posaconazole
HCPCS
No data
Clinical
Clinical Trials
105 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MycosesD009181B35-B49781071244
Invasive fungal infectionsD0000727424375726
InfectionsD007239EFO_00005445564524
Myeloid leukemia acuteD015470C92.08914420
LeukemiaD007938C957101417
Myeloid leukemiaD007951C925813417
Communicable diseasesD0031415132415
AspergillosisD001228EFO_0007157B441242412
Myelodysplastic syndromesD009190D46141319
Invasive pulmonary aspergillosisD055744B44.0112127
Show 17 more
Indications Phases 3
Indications Phases 2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients112
Multiple myelomaD009101C90.011
Plasma cell neoplasmsD05421911
Large b-cell lymphoma diffuseD016403C83.311
RecurrenceD01200811
Brain neoplasmsD001932EFO_0003833C7111
GliomaD005910EFO_000052011
GlioblastomaD005909EFO_000051511
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hematologic diseasesD006402EFO_0005803D75.933
Critical illnessD01663822
Kidney diseasesD007674EFO_0003086N0811
Fungal lung diseasesD008172EFO_000727811
Genetic predisposition to diseaseD02002211
FusariosisD060585EFO_100179511
InflammationD007249MP_000184511
MucositisD052016EFO_100189811
Lung transplantationD01604011
Covid-19D000086382U07.111
Show 6 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePosaconazole
INNposaconazole
Description
Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication.
Classification
Small molecule
Drug classsystemic antifungals (miconazole type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC[C@@H]([C@H](C)O)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@@](Cn6cncn6)(c6ccc(F)cc6F)C5)cc4)CC3)cc2)c1=O
Identifiers
PDB
CAS-ID171228-49-2
RxCUI
ChEMBL IDCHEMBL1397
ChEBI ID64355
PubChem CID147912
DrugBankDB01263
UNII ID6TK1G07BHZ (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
Noxafil Merck & Co
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Estimated US medical usage
Posaconazole
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,569 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6,815 adverse events reported
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