Pomalyst, Imnovid (previously pomalidomide celgene)(pomalidomide)
Imnovid, Pomalidomide, Pomalyst (pomalidomide) is a small molecule pharmaceutical. Pomalidomide was first approved as Pomalyst on 2013-02-08. It is used to treat kaposi sarcoma and multiple myeloma in the USA. It has been approved in Europe to treat multiple myeloma. It is known to target protein cereblon.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Pomalidomide, Pomalyst (discontinued: Pomalidomide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pomalidomide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| POMALYST | Bristol Myers Squibb | N-204026 RX | 2013-02-08 | 4 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| pomalyst | New Drug Application | 2023-03-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| multiple myeloma | — | D009101 | C90.0 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
POMALIDOMIDE, POMALYST, BRISTOL | |||
| 2027-11-14 | PED | ||
| 2027-05-14 | ODE-296, ODE-297 | ||
| 2024-05-20 | PED | ||
| 2023-11-20 | M-14 | ||
HCPCS
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Clinical
Clinical Trials
293 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 84 | 120 | 38 | 3 | 18 | 223 |
| Plasma cell neoplasms | D054219 | — | — | 80 | 114 | 37 | 3 | 16 | 211 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 5 | 7 | 3 | — | 1 | 15 |
| Neoplasms | D009369 | — | C80 | 9 | 7 | 2 | — | — | 14 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 3 | 4 | 1 | — | — | 6 |
| Primary myelofibrosis | D055728 | — | D47.4 | 2 | 4 | 1 | — | — | 5 |
| Plasmacytoma | D010954 | — | C90.3 | — | 2 | 1 | — | — | 3 |
| Polycythemia vera | D011087 | — | D45 | 1 | 2 | 1 | — | — | 3 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | 2 | 1 | — | — | 3 |
| Blood protein disorders | D001796 | — | — | 1 | 2 | 1 | — | — | 3 |
| Paraproteinemias | D010265 | — | D47.2 | 1 | 2 | 1 | — | — | 3 |
| Polycythemia | D011086 | EFO_0005804 | D75.1 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 10 | 10 | — | — | — | 16 |
| Amyloidosis | D000686 | EFO_1001875 | E85 | 5 | 10 | — | — | 2 | 14 |
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | 4 | 7 | — | — | 1 | 10 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 5 | 4 | — | — | 1 | 9 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 6 | 4 | — | — | — | 7 |
| B-cell lymphoma | D016393 | — | — | 4 | 3 | — | — | 1 | 7 |
| Leukemia | D007938 | — | C95 | 2 | 5 | — | — | — | 7 |
| Sarcoma | D012509 | — | — | 2 | 4 | — | — | — | 5 |
| Kaposi sarcoma | D012514 | — | C46 | 3 | 3 | — | — | — | 5 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | 3 | — | — | — | 5 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 4 | — | — | — | — | 4 |
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Intraocular lymphoma | D064090 | — | — | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Neurofibromatosis 1 | D009456 | — | Q85.01 | 1 | — | — | — | — | 1 |
| Neurofibromatoses | D017253 | — | Q85.00 | 1 | — | — | — | — | 1 |
| Pathologic dilatation | D004108 | — | — | 1 | — | — | — | — | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypoxia | D000860 | HP_0012418 | R09.02 | — | — | — | — | 1 | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
| Communicable diseases | D003141 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pomalidomide |
| INN | pomalidomide |
| Description | Pomalidomide is an aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies. It has a role as an antineoplastic agent, an immunomodulator and an angiogenesis inhibitor. It is a dicarboximide, a member of isoindoles, a member of piperidones and an aromatic amine. It is functionally related to a thalidomide. |
| Classification | Small molecule |
| Drug class | thalidomide derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O |
Identifiers
| PDB | — |
| CAS-ID | 19171-19-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL43452 |
| ChEBI ID | 72690 |
| PubChem CID | 134780 |
| DrugBank | DB08910 |
| UNII ID | D2UX06XLB5 (ChemIDplus, GSRS) |
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Pomalyst – Bristol Myers Squibb
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Pomalyst – Celgene
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Safety
Black-box Warning
Black-box warning for: Pomalyst
Adverse Events
Top Adverse Reactions
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83,040 adverse events reported
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