Polihexanide
Polihexanide is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alcohol free antibacterial hand sanitizer | unapproved drug other | 2022-03-08 |
| drop dream eye 2 | unapproved drug other | 2024-05-28 |
| hba anti bacterial liquid | unapproved drug other | 2020-07-22 |
| hba sanitary wipes | unapproved drug other | 2020-07-22 |
| phmb disinfectant | unapproved drug other | 2020-05-22 |
| wash free hand sanitizer(alcohol free) | unapproved drug other | 2020-03-30 |
Indications
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Agency Specific
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Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wounds and injuries | D014947 | — | T14.8 | — | 2 | 1 | 4 | 9 | 16 |
| Surgical wound | D000072836 | — | — | — | — | — | 1 | 5 | 6 |
| Surgical wound infection | D013530 | — | — | — | — | 1 | 2 | 2 | 5 |
| Wound infection | D014946 | — | — | — | — | 1 | 2 | 1 | 4 |
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | 3 | — | 4 |
| Skin diseases | D012871 | — | L00-L99 | — | 1 | — | 1 | — | 2 |
| Papillomavirus infections | D030361 | — | — | — | — | — | 2 | — | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | — | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | 1 | — | 1 |
| Nail diseases | D009260 | — | L60 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ulcer | D014456 | MPATH_579 | — | — | — | 1 | — | 8 | 9 |
| Keratitis | D007634 | — | H16 | 1 | — | 2 | — | 1 | 4 |
| Acanthamoeba keratitis | D015823 | EFO_0007126 | — | 1 | — | 2 | — | 1 | 4 |
| Skin ulcer | D012883 | — | L98.4 | — | — | 1 | — | 1 | 2 |
| Communicable diseases | D003141 | — | — | — | — | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mycoses | D009181 | — | B35-B49 | — | 1 | — | — | — | 1 |
| Onychomycosis | D014009 | — | B35.1 | — | 1 | — | — | — | 1 |
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pressure ulcer | D003668 | — | L89 | — | — | — | — | 6 | 6 |
| Varicose ulcer | D014647 | — | — | — | — | — | — | 4 | 4 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | — | — | 4 | 4 |
| Foot ulcer | D016523 | — | — | — | — | — | — | 4 | 4 |
| Leg ulcer | D007871 | — | — | — | — | — | — | 2 | 2 |
| Wound healing | D014945 | GO_0042060 | — | — | — | — | — | 2 | 2 |
| Contact lenses | D003261 | — | — | — | — | — | — | 2 | 2 |
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | — | 2 | 2 |
| Diabetes complications | D048909 | — | — | — | — | — | — | 1 | 1 |
| Burns | D002056 | — | T30.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Polihexanide |
| INN | polihexanide |
| Description | Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under the names Lavasept, Serasept, Prontosan, and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCCNC(=N)NC(=N)N |
Identifiers
| PDB | — |
| CAS-ID | 28757-47-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2106939 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB12277 |
| UNII ID | 322U039GMF (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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70 adverse events reported
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