Piroxicam
Feldene, Piroxicam (piroxicam) is a small molecule pharmaceutical. Piroxicam was first approved as Feldene on 1982-04-06. It is used to treat ankylosing spondylitis, inflammation, osteoarthritis, rheumatoid arthritis, and sunburn in the USA.
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Commercial
Trade Name
FDA
EMA
Feldene (generic drugs available since 1992-12-11)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| feldene | ANDA | 2010-02-09 |
| piroxicam | ANDA | 2024-08-01 |
| therafeldamine | unapproved drug other | 2011-08-01 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AC: Oxicams, antiinflammatory and antirheumatic drugs
— M01AC01: Piroxicam
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA07: Piroxicam
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01B: Antiinflammatory agents, ophthalmologic
— S01BC: Antiinflammatory agents, non-steroidal, ophthalmologic
— S01BC06: Piroxicam
HCPCS
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Clinical
Clinical Trials
34 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulpitis | D011671 | EFO_1001139 | K04.0 | 1 | — | — | 1 | 2 | 4 |
| Dysmenorrhea | D004412 | HP_0100607 | N94.6 | — | — | — | 2 | 1 | 3 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | 1 | — | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 1 | — | 1 |
| Impacted tooth | D014095 | HP_0011079 | K01.1 | — | — | — | 1 | — | 1 |
| Cardiac surgical procedures | D006348 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 1 | 1 | 2 | — | 2 | 5 |
| Postcoital contraception | D044363 | — | — | — | 2 | 1 | — | — | 2 |
| Acute pain | D059787 | — | R52 | — | 1 | 2 | — | — | 2 |
| Renal colic | D056844 | EFO_1001412 | N23 | — | 1 | 1 | — | — | 2 |
| Colic | D003085 | HP_0011848 | R10.83 | — | 1 | 1 | — | — | 2 |
| Wound infection | D014946 | — | — | — | 1 | 1 | — | — | 1 |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | — | 1 | — | — | 1 |
| Hernia | D006547 | HP_0100790 | K40-K46 | — | — | 1 | — | — | 1 |
| Tennis elbow | D013716 | EFO_1001896 | M77.1 | — | 1 | 1 | — | — | 1 |
| Endodontics | D004708 | — | — | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 1 | — | — | 1 | 2 |
| Bunion | D000071378 | — | M21.61 | — | 1 | — | — | — | 1 |
| Orthopedic procedures | D019637 | — | — | — | 1 | — | — | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | — | — | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | — | — | 1 |
| Headache | D006261 | HP_0002315 | R51 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | — | — | — | 2 | 2 |
| Premenstrual syndrome | D011293 | — | N94.3 | — | — | — | — | 2 | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | — | — | — | — | 1 | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | — | — | 1 | 1 |
| Breakthrough pain | D059390 | — | — | — | — | — | — | 1 | 1 |
| Dermatitis | D003872 | HP_0011123 | L30.9 | — | — | — | — | 1 | 1 |
| Photoallergic dermatitis | D017454 | — | — | — | — | — | — | 1 | 1 |
| Nonvital tooth | D019553 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Piroxicam |
| INN | piroxicam |
| Description | Piroxicam is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling. It has a role as an analgesic, a cyclooxygenase 1 inhibitor, a non-steroidal anti-inflammatory drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and an antirheumatic drug. It is a benzothiazine, a member of pyridines and a monocarboxylic acid amide. |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (isoxicam type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O |
Identifiers
| PDB | — |
| CAS-ID | 36322-90-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL527 |
| ChEBI ID | 8249 |
| PubChem CID | 54676228 |
| DrugBank | DB00554 |
| UNII ID | 13T4O6VMAM (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Piroxicam
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Number of purchases
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Feldene, Piroxicam, Therafeldamine
Adverse Events
Top Adverse Reactions
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2,870 adverse events reported
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