Drug common name | Pirarubicin |
INN | pirarubicin |
Description | Pirarubicin (INN) is an anthracycline drug.
An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.
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Classification | Small molecule |
Drug class | antineoplastic antibiotics (daunorubicin type) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O[C@@H]2CCCCO2)[C@H](C)O1 |
PDB | — |
CAS-ID | 72496-41-4 |
RxCUI | — |
ChEMBL ID | CHEMBL2354444 |
ChEBI ID | — |
PubChem CID | 3033521 |
DrugBank | — |
UNII ID | D58G680W0G (ChemIDplus, GSRS) |