Pirarubicin
Pirarubicin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
55 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | — | 11 | 6 | 1 | 7 | 23 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | 8 | 6 | 1 | 8 | 21 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 4 | 4 | 1 | 7 | 14 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 5 | 4 | 1 | 2 | 12 |
| Lymphoma | D008223 | — | C85.9 | — | 3 | — | 1 | — | 4 |
| T-cell lymphoma | D016399 | — | — | — | 1 | — | 1 | — | 2 |
| T-cell lymphoma peripheral | D016411 | — | — | — | 1 | — | 1 | — | 2 |
| Therapeutic chemoembolization | D016461 | — | — | — | — | — | 1 | 1 | 2 |
| Multiple myeloma | D009101 | — | C90.0 | — | — | — | 1 | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | — | 3 | 1 | — | — | 3 |
| Progression-free survival | D000077982 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | — | 4 | — | — | 1 | 5 |
| Transitional cell carcinoma | D002295 | — | — | — | 4 | — | — | — | 4 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | — | 2 | — | — | — | 2 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | 1 | — | — | 1 | 2 |
| Osteosarcoma | D012516 | — | — | — | 2 | — | — | — | 2 |
| Neoadjuvant therapy | D020360 | — | — | — | 1 | — | — | — | 1 |
| Antineoplastic combined chemotherapy protocols | D000971 | — | — | — | 1 | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | — | 1 | — | — | — | 1 |
| Lymphoid leukemia | D007945 | — | C91 | — | 1 | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | — | — | — | 1 | — | — | — | 1 |
Show 7 more
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Radiofrequency ablation | D000078703 | — | — | — | — | — | — | 1 | 1 |
| Catheter ablation | D017115 | — | — | — | — | — | — | 1 | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 1 | 1 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pirarubicin |
| INN | pirarubicin |
| Description | Pirarubicin (INN) is an anthracycline drug.
An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.
|
| Classification | Small molecule |
| Drug class | antineoplastic antibiotics (daunorubicin type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O[C@@H]2CCCCO2)[C@H](C)O1 |
Identifiers
| PDB | — |
| CAS-ID | 72496-41-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2354444 |
| ChEBI ID | — |
| PubChem CID | 3033521 |
| DrugBank | DB11616 |
| UNII ID | D58G680W0G (ChemIDplus, GSRS) |
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Trends
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Safety
Black-box Warning
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Adverse Events
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1,474 adverse events reported
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