Piperacillin
Piperacillin, Zosyn (piperacillin) is a small molecule pharmaceutical. Piperacillin was first approved as Pipracil on 1982-01-01. It is used to treat bacterial infections, escherichia coli infections, infectious skin diseases, intraabdominal infections, and pelvic infection amongst others in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Combinations
Zosyn (generic drugs available since 2003-11-14)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| piperacillin and tazobactam | ANDA | 2024-09-12 |
| piperacillin sodium and tazobactam sodium | ANDA | 2022-08-26 |
| piperacillin, tazobactam | ANDA | 2024-01-17 |
| pipracil | 2007-04-24 | |
| zosyn | New Drug Application | 2024-05-01 |
Indications
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EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01C: Beta-lactam antibacterials, penicillins
— J01CA: Penicillins with extended spectrum
— J01CA12: Piperacillin
— J01CR: Combinations of penicillins, incl. beta-lactamase inhibitors
— J01CR05: Piperacillin and beta-lactamase inhibitor
Clinical
Clinical Trials
196 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | 6 | 14 | 13 | 14 | 45 |
| Sepsis | D018805 | HP_0100806 | A41.9 | 1 | 1 | 5 | 7 | 18 | 31 |
| Communicable diseases | D003141 | — | — | — | 3 | 8 | 8 | 6 | 24 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 2 | 11 | 5 | 6 | 23 |
| Bacterial infections | D001424 | — | A49 | 1 | — | — | 5 | 11 | 17 |
| Appendicitis | D001064 | EFO_0007149 | K37 | 1 | 2 | — | 5 | 6 | 14 |
| Neutropenia | D009503 | — | D70 | — | 2 | — | 5 | 6 | 13 |
| Fever | D005334 | HP_0001945 | R50.9 | — | 3 | 1 | 5 | 3 | 12 |
| Critical illness | D016638 | — | — | — | 1 | — | 1 | 10 | 12 |
| Septic shock | D012772 | — | A48.3 | — | — | 3 | 3 | 6 | 12 |
Show 40 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | 1 | — | 3 | 4 |
| Healthcare-associated pneumonia | D000077299 | — | — | — | 1 | 3 | — | 1 | 4 |
| Hematologic neoplasms | D019337 | — | — | — | 1 | 1 | — | 2 | 4 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | — | 1 | 1 | — | 1 | 3 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | — | 3 | — | — | 3 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | 2 | 2 | — | — | 3 |
| Neoplasms | D009369 | — | C80 | — | 2 | 1 | — | — | 3 |
| Bronchitis | D001991 | — | J40 | — | 1 | 1 | — | 1 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | 1 | — | 1 | 2 |
| Acute cholecystitis | D041881 | EFO_1001289 | K81.0 | — | — | 1 | — | 1 | 2 |
Show 32 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | 1 | — | — | — | 2 |
| Gastrointestinal microbiome | D000069196 | — | — | — | 1 | — | — | — | 1 |
| Otitis media | D010033 | EFO_0004992 | H66.9 | 1 | 1 | — | — | — | 1 |
| Otitis | D010031 | — | — | 1 | 1 | — | — | — | 1 |
| Graft vs host disease | D006086 | — | D89.81 | — | 1 | — | — | — | 1 |
| Cross infection | D003428 | — | — | — | 1 | — | — | — | 1 |
| Pancreatic fistula | D010185 | — | — | — | 1 | — | — | — | 1 |
| Fistula | D005402 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | 1 | 5 |
| Acute disease | D000208 | — | — | 1 | — | — | — | 2 | 3 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | — | — | — | — | 3 | 3 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 2 | 2 |
| Drug monitoring | D016903 | — | — | — | — | — | — | 2 | 2 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | — | 2 | 2 |
| Hematopoietic stem cell transplantation | D018380 | — | — | — | — | — | — | 2 | 2 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | — | — | 2 | 2 |
| Gram-positive bacterial infections | D016908 | — | — | — | — | — | — | 2 | 2 |
| Cytokine release syndrome | D000080424 | — | D89.83 | — | — | — | — | 1 | 1 |
| Viral pneumonia | D011024 | EFO_0007541 | J12.9 | — | — | — | — | 1 | 1 |
| Chronic bronchitis | D029481 | — | J42 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Piperacillin |
| INN | piperacillin |
| Description | Piperacillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group. It has a role as an antibacterial drug. It is a penicillin and a penicillin allergen. It is a conjugate acid of a piperacillin(1-). |
| Classification | Small molecule |
| Drug class | penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN1CCN(C(=O)N[C@@H](C(=O)N[C@@H]2C(=O)N3[C@@H](C(=O)O)C(C)(C)S[C@H]23)c2ccccc2)C(=O)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 61477-96-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL702 |
| ChEBI ID | 8232 |
| PubChem CID | 43672 |
| DrugBank | DB00319 |
| UNII ID | 9I628532GX (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Zosyn – Pfizer
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Estimated US medical usage
Piperacillin
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Tazobactam
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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21,513 adverse events reported
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