Piperacillin - PharmaKB

Piperacillin

Piperacillin, Zosyn (piperacillin) is a small molecule pharmaceutical. Piperacillin was first approved as Pipracil on 1982-01-01. It is used to treat bacterial infections, escherichia coli infections, infectious skin diseases, intraabdominal infections, and pelvic infection amongst others in the USA.

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Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
respiratory tract diseases	D012140
urogenital diseases	D000091642
skin and connective tissue diseases	D017437

Trade Name

FDA

EMA

Combinations

Piperacillin tazobactam, Zosyn (discontinued: Piperacillin tazobactam, Zosyn)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Piperacillin sodium

Tradename	Company	Number	Date	Products
PIPRACIL	Wyeth	N-050545 DISCN	1982-01-01	4 products, RLD

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Piperacillin sodium

Tazobactam sodium

Tradename	Company	Number	Date	Products
ZOSYN IN PLASTIC CONTAINER	Baxter	N-050750 RX	1998-02-24	3 products, RLD, RS

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Labels

FDA

EMA

Brand Name	Status	Last Update
piperacillin and tazobactam	ANDA	2025-02-26
piperacillin sodium and tazobactam sodium	ANDA	2024-12-10
piperacillin, tazobactam	ANDA	2024-08-31
pipracil		2007-04-24
zosyn	New Drug Application	2024-12-03

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
pneumonia	EFO_0003106	D011014	J18
urinary tract infections	EFO_0003103	D014552	N39.0
bacterial infections	—	D001424	A49
intraabdominal infections	—	D059413	—
pseudomonas infections	EFO_0001076	D011552	A41.52
infectious skin diseases	—	D012874	—
escherichia coli infections	EFO_1001318	D004927	B96.20
pelvic infection	—	D034161	—
soft tissue infections	—	D018461	—
streptococcal infections	EFO_1001476	D013290	—

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Agency Specific

FDA

EMA

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Patent Expiration

No data

ATC Codes

J: Antiinfectives for systemic use

— J01: Antibacterials for systemic use

— J01C: Beta-lactam antibacterials, penicillins

— J01CA: Penicillins with extended spectrum

— J01CA12: Piperacillin

— J01CR: Combinations of penicillins, incl. beta-lactamase inhibitors

— J01CR05: Piperacillin and beta-lactamase inhibitor

HCPCS

Code	Description
J2543	Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)
S0081	Injection, piperacillin sodium, 500 mg

Clinical

Clinical Trials

199 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Infections	D007239	EFO_0000544	—	1	6	14	14	15	47
Sepsis	D018805	EFO_0001420	A41.9	1	1	5	8	19	33
Communicable diseases	D003141	—	—	—	3	8	8	6	24
Pneumonia	D011014	EFO_0003106	J18	—	2	11	5	6	23
Bacterial infections	D001424	—	A49	1	—	—	5	11	17
Neutropenia	D009503	—	D70	—	2	—	5	6	13
Critical illness	D016638	—	—	—	1	—	1	11	13
Appendicitis	D001064	EFO_0007149	K37	—	2	—	5	6	13
Toxemia	D014115	—	—	—	—	1	4	8	13
Fever	D005334	—	R50.9	—	3	1	5	3	12

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Covid-19	D000086382	—	U07.1	—	—	1	—	3	4
Healthcare-associated pneumonia	D000077299	—	—	—	1	3	—	1	4
Hematologic neoplasms	D019337	—	—	—	1	1	—	2	4
Systemic inflammatory response syndrome	D018746	EFO_1001478	R65.10	—	1	1	—	1	3
Bacterial pneumonia	D018410	EFO_1001272	J15.9	—	—	3	—	—	3
Pyelonephritis	D011704	EFO_1001141	N10-N16	—	2	2	—	—	3
Neoplasms	D009369	—	C80	—	2	1	—	—	3
Bronchitis	D001991	—	J40	—	1	1	—	1	2
Inflammation	D007249	MP_0001845	—	—	—	1	—	1	2
Acute cholecystitis	D041881	EFO_1001289	K81.0	—	—	1	—	1	2

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Osteomyelitis	D010019	EFO_0003102	M86	1	1	—	—	—	2
Gastrointestinal microbiome	D000069196	—	—	—	1	—	—	—	1
Otitis media	D010033	EFO_0004992	H66.9	1	1	—	—	—	1
Otitis	D010031	—	—	1	1	—	—	—	1
Graft vs host disease	D006086	—	D89.81	—	1	—	—	—	1
Cross infection	D003428	—	—	—	1	—	—	—	1
Pancreatic fistula	D010185	—	—	—	1	—	—	—	1
Fistula	D005402	—	—	—	1	—	—	—	1

Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Healthy volunteers/patients	—	—	—	4	—	—	—	1	5

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Pharmacokinetics	D010599	—	—	—	—	—	—	3	3
Acute disease	D000208	—	—	—	—	—	—	2	2
Hemorrhage	D006470	MP_0001914	R58	—	—	—	—	2	2
Drug monitoring	D016903	—	—	—	—	—	—	2	2
Chronic kidney failure	D007676	EFO_0003884	N18.6	—	—	—	—	2	2
Antibiotic prophylaxis	D019072	—	—	—	—	—	—	2	2
Hematopoietic stem cell transplantation	D018380	—	—	—	—	—	—	2	2
Heart arrest	D006323	EFO_0009492	I46	—	—	—	—	2	2
Gram-positive bacterial infections	D016908	—	—	—	—	—	—	2	2
Cytokine release syndrome	D000080424	—	D89.83	—	—	—	—	1	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Piperacillin
INN	piperacillin
Description	Piperacillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group. It has a role as an antibacterial drug. It is a penicillin and a penicillin allergen. It is a conjugate acid of a piperacillin(1-).
Classification	Small molecule
Drug class	penicillins
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CCN1CCN(C(=O)N[C@@H](C(=O)N[C@@H]2C(=O)N3[C@@H](C(=O)O)C(C)(C)S[C@H]23)c2ccccc2)C(=O)C1=O