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AboutPricing
Drug ReportsPiperacillin
Piperacillin
Piperacillin, Zosyn (piperacillin) is a small molecule pharmaceutical. Piperacillin was first approved as Pipracil on 1982-01-01. It is used to treat bacterial infections, escherichia coli infections, infectious skin diseases, intraabdominal infections, and pelvic infection amongst others in the USA.
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Variants
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FDA approval date
EMA approval date
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Study first post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Combinations
Piperacillin tazobactam, Zosyn (discontinued: Piperacillin tazobactam, Zosyn)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Piperacillin sodium
Tradename
Company
Number
Date
Products
PIPRACILWyethN-050545 DISCN1982-01-01
4 products, RLD
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Piperacillin sodium
+
Tazobactam sodium
Tradename
Company
Number
Date
Products
PIPERACILLIN AND TAZOBACTAM AND SODIUM CHLORIDE IN DUPLEX CONTAINERB. Braun MedicalN-206056 RX2025-04-03
3 products, RLD, RS
ZOSYN IN PLASTIC CONTAINERBaxterN-050750 RX1998-02-24
3 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
piperacillin and tazobactamANDA2025-09-08
piperacillin and tazobactam and sodium chlorideNew Drug Application2025-04-17
piperacillin sodium and tazobactam sodiumANDA2024-12-10
piperacillin, tazobactamANDA2024-08-31
pipracil2007-04-24
zosynNew Drug Application2024-12-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
pneumoniaEFO_0003106D011014J18
urinary tract infectionsEFO_0003103D014552N39.0
bacterial infections—D001424A49
intraabdominal infections—D059413—
pseudomonas infectionsEFO_0001076D011552A41.52
infectious skin diseases—D012874—
escherichia coli infectionsEFO_1001318D004927B96.20
pelvic infection—D034161—
soft tissue infections—D018461—
streptococcal infectionsEFO_1001476D013290—
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01C: Beta-lactam antibacterials, penicillins
— J01CA: Penicillins with extended spectrum
— J01CA12: Piperacillin
— J01CR: Combinations of penicillins, incl. beta-lactamase inhibitors
— J01CR05: Piperacillin and beta-lactamase inhibitor
HCPCS
Code
Description
J2543
Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)
S0081
Injection, piperacillin sodium, 500 mg
Clinical
Clinical Trials
209 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
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Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SepsisD018805EFO_0001420A41.9————11
Acute kidney injuryD058186—N17————11
HemodiafiltrationD017583——————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePiperacillin
INNpiperacillin
Description
Piperacillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group. It has a role as an antibacterial drug. It is a penicillin and a penicillin allergen. It is a conjugate acid of a piperacillin(1-).
Classification
Small molecule
Drug classpenicillins
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Structure (InChI/SMILES or Protein Sequence)
CCN1CCN(C(=O)N[C@@H](C(=O)N[C@@H]2C(=O)N3[C@@H](C(=O)O)C(C)(C)S[C@H]23)c2ccccc2)C(=O)C1=O
Identifiers
PDB—
CAS-ID61477-96-1
RxCUI—
ChEMBL IDCHEMBL702
ChEBI ID8232
PubChem CID43672
DrugBankDB00319
UNII ID9I628532GX (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Zosyn – Pfizer
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Estimated US medical usage
Piperacillin
+
Tazobactam
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 45,482 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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23,152 adverse events reported
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