Therapeutic Area | MeSH |
---|---|
nutritional and metabolic diseases | D009750 |
endocrine system diseases | D004700 |
Brand Name | Status | Last Update |
---|---|---|
alogliptin and pioglitazone | NDA authorized generic | 2022-09-20 |
duetact | New Drug Application | 2022-10-24 |
oseni | New Drug Application | 2023-12-04 |
pioglitazone and glimepiride | NDA authorized generic | 2021-12-16 |
pioglitazone hydrochloride and glimepiride | ANDA | 2018-06-18 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
type 2 diabetes mellitus | EFO_0001360 | D003924 | E11 |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Alogliptin Benzoate / Pioglitazone Hydrochloride, Oseni, Takeda Pharms Usa | |||
8637079 | 2029-06-04 | DP | |
7807689 | 2028-06-27 | DS, DP | U-1337 |
8173663 | 2025-03-15 | U-1338 | |
8288539 | 2025-03-15 | DP | |
Metformin Hydrochloride / Pioglitazone Hydrochloride, Actoplus Met, Takeda Pharms Usa | |||
9320714 | 2029-02-03 | DP | |
9101660 | 2027-01-22 | DP | |
Glimepiride / Pioglitazone Hydrochloride, Duetact, Takeda Pharms Usa | |||
8071130 | 2028-06-08 | DP | |
7700128 | 2027-01-30 | DP | |
Metformin Hydrochloride / Pioglitazone Hydrochloride, Actoplus Met Xr, Takeda Pharms Usa | |||
7785627 | 2026-07-31 | DP | |
7959946 | 2026-07-31 | DP | |
8470368 | 2023-09-19 | DP | |
8668931 | 2023-09-19 | DP | |
9060941 | 2023-09-19 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 7 | 34 | 84 | 67 | 48 | 231 |
Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 7 | 16 | 12 | 1 | 36 |
Insulin resistance | D007333 | HP_0000855 | E88.819 | 3 | 8 | 5 | 10 | 5 | 29 |
Healthy volunteers/patients | — | — | — | 24 | 1 | — | 1 | 1 | 27 |
Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | 4 | 1 | 12 | — | 18 |
Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | 3 | 4 | 1 | 6 | 4 | 17 |
Obesity | D009765 | EFO_0001073 | E66.9 | 4 | 2 | 1 | 3 | 6 | 16 |
Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 4 | 1 | — | 4 | 2 | 11 |
Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | 1 | 2 | 4 | 8 |
Coronary artery disease | D003324 | — | I25.1 | — | 2 | 2 | 4 | — | 7 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 3 | 1 | — | — | 4 |
Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 2 | — | 1 | — | 1 | 4 |
Prostatic neoplasms | D011471 | — | C61 | 1 | 2 | 1 | — | — | 4 |
Hiv-associated lipodystrophy syndrome | D039682 | EFO_1001348 | — | — | 1 | 1 | — | 1 | 3 |
Kidney transplantation | D016030 | — | — | — | 1 | 1 | — | 1 | 3 |
Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | 2 | — | — | 3 |
Dyslipidemias | D050171 | HP_0003119 | — | — | — | 1 | — | 1 | 2 |
Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | 1 | — | — | 1 |
Risk reduction behavior | D040242 | — | — | — | — | 1 | — | — | 1 |
Coronary restenosis | D023903 | EFO_0004224 | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Alcoholism | D000437 | EFO_0003829 | F10.1 | 3 | 5 | — | — | 1 | 6 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | — | 5 | — | — | — | 5 |
Non-small-cell lung carcinoma | D002289 | — | — | — | 3 | — | — | — | 3 |
Oral leukoplakia | D007972 | — | K13.21 | — | 3 | — | — | — | 3 |
Myeloid leukemia chronic-phase | D015466 | — | — | 1 | 2 | — | — | — | 2 |
Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 1 | — | — | — | 2 |
Opioid-related disorders | D009293 | EFO_0005611 | F11 | 1 | 1 | — | — | — | 2 |
Squamous cell carcinoma | D002294 | — | — | — | 2 | — | — | — | 2 |
Hepatitis | D006505 | HP_0012115 | K75.9 | — | 2 | — | — | — | 2 |
Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | 1 | 2 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | — | — | — | 2 | 3 |
Drug interactions | D004347 | — | — | 2 | — | — | — | — | 2 |
Infertility | D007246 | HP_0000789 | — | 2 | — | — | — | — | 2 |
Castration-resistant prostatic neoplasms | D064129 | — | — | 2 | — | — | — | — | 2 |
Peripheral arterial disease | D058729 | EFO_0004265 | — | 1 | — | — | — | — | 1 |
Female infertility | D007247 | EFO_0008560 | N97 | 1 | — | — | — | — | 1 |
Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
Pneumonia | D011014 | EFO_0003106 | — | 1 | — | — | — | — | 1 |
Gastroparesis | D018589 | EFO_1000948 | K31.84 | 1 | — | — | — | — | 1 |
Myositis | D009220 | EFO_0000783 | G72.49 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | — | — | 2 | 2 |
Urinary bladder neoplasms | D001749 | — | C67 | — | — | — | — | 2 | 2 |
Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 1 | 1 |
Ketosis | D007662 | HP_0002919 | R82.4 | — | — | — | — | 1 | 1 |
Diabetic ketoacidosis | D016883 | EFO_1000897 | — | — | — | — | — | 1 | 1 |
Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | — | — | 1 | 1 |
Peritoneal dialysis | D010530 | — | — | — | — | — | — | 1 | 1 |
Hypertriglyceridemia | D015228 | EFO_0004211 | — | — | — | — | — | 1 | 1 |
Hypogonadism | D007006 | HP_0000044 | E23.0 | — | — | — | — | 1 | 1 |
Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 1 | 1 |
Drug common name | Pioglitazone |
INN | pioglitazone |
Description | Pioglitazone is a member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. It has a role as an insulin-sensitizing drug, an EC 2.7.1.33 (pantothenate kinase) inhibitor, a xenobiotic, an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor, a ferroptosis inhibitor, a cardioprotective agent, a PPARgamma agonist, an antidepressant, a geroprotector and a hypoglycemic agent. It is a member of thiazolidinediones, an aromatic ether and a member of pyridines. |
Classification | Small molecule |
Drug class | peroxisome proliferator activiating receptor (PPAR) agonists (thiazolidene derivatives) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 |
PDB | — |
CAS-ID | 111025-46-8 |
RxCUI | — |
ChEMBL ID | CHEMBL595 |
ChEBI ID | 8228 |
PubChem CID | 4829 |
DrugBank | DB01132 |
UNII ID | X4OV71U42S (ChemIDplus, GSRS) |