Pimozide
Pimozide (pimozide) is a small molecule pharmaceutical. Pimozide was first approved as Orap on 1984-07-31. It is used to treat huntington disease, psychotic disorders, schizophrenia spectrum and other psychotic disorders, and tourette syndrome in the USA. The pharmaceutical is active against D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A. In addition, it is known to target D(3) dopamine receptor, voltage-dependent T-type calcium channel subunit alpha-1I, G protein-activated inward rectifier potassium channel 2, voltage-dependent T-type calcium channel subunit alpha-1G, potassium voltage-gated channel subfamily A member 10, 5-hydroxytryptamine receptor 1A, histamine H1 receptor, 5-hydroxytryptamine receptor 7, voltage-dependent T-type calcium channel subunit alpha-1H, and 5-hydroxytryptamine receptor 6.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Pimozide (discontinued: Orap)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| orapaz | unapproved drug other | 2025-02-11 |
| orapred | New Drug Application | 2025-06-03 |
| orapro fluoride anticavity | C200263 | 2025-07-10 |
| pimozide | ANDA | 2026-08-12 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | 1 | 3 | 2 | 7 |
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | 1 | 2 | 1 | 5 |
| Schizophrenia spectrum and other psychotic disorders | D019967 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 1 | 1 | — | — | 2 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Depression | D003863 | — | F33.9 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 2 | — | — | — | 2 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 2 | — | — | — | 2 |
| Sclerosis | D012598 | — | — | — | 2 | — | — | — | 2 |
| Intellectual disability | D008607 | EFO_0003847 | F73 | — | 1 | — | — | — | 1 |
| Tourette syndrome | D005879 | EFO_0004895 | F95.2 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Long qt syndrome | D008133 | HP_0001657 | I45.81 | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Pharmacological phenomena | D000069437 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Emergencies | D004630 | — | — | — | — | — | — | 1 | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 1 | 1 |
| Tinnitus | D014012 | — | H93.1 | — | — | — | — | 1 | 1 |
| Post-acute covid-19 syndrome | D000094024 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pimozide |
| INN | pimozide |
| Description | Pimozide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophenyl)butyl group. It has a role as a H1-receptor antagonist, a serotonergic antagonist, a first generation antipsychotic, an antidyskinesia agent and a dopaminergic antagonist. It is a member of benzimidazoles, an organofluorine compound and a heteroarylpiperidine. |
| Classification | Small molecule |
| Drug class | Typical antipsychotic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 2062-78-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1423 |
| ChEBI ID | 8212 |
| PubChem CID | 16362 |
| DrugBank | DB01100 |
| UNII ID | 1HIZ4DL86F (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CACNA1I
CACNA1I
CACNA1H
CACNA1H
Organism
Homo sapiens
Gene name
CACNA1I
Gene synonyms
KIAA1120
NCBI Gene ID
Protein name
voltage-dependent T-type calcium channel subunit alpha-1I
Protein synonyms
Ca(v)3.3, calcium channel, voltage-dependent, alpha 1I subunit, calcium channel, voltage-dependent, T type, alpha 1I subunit, Voltage-gated calcium channel subunit alpha Cav3.3
Uniprot ID
Mouse ortholog
Cacna1i (239556)
voltage-dependent T-type calcium channel subunit alpha-1I (E9Q7P2)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Pimozide
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,844 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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17,349 adverse events reported
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