Pimavanserin
Nuplazid, Pimavanserin (pimavanserin) is a small molecule pharmaceutical. Pimavanserin was first approved as Nuplazid on 2016-04-29. It is used to treat hallucinations, parkinson disease, and schizophrenia spectrum and other psychotic disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 2A.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Nuplazid (discontinued: Nuplazid, Pimavanserin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pimavanserin tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NUPLAZID | Acadia Pharmaceuticals | N-207318 RX | 2018-06-28 | 1 products, RLD, RS |
| NUPLAZID | Acadia Pharmaceuticals | N-210793 RX | 2018-06-28 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| nuplazid | New Drug Application | 2023-09-19 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Pimavanserin Tartrate, Nuplazid, Acadia Pharms Inc | |||
| 10449185 | 2038-08-27 | DP | |
| 10646480 | 2038-08-27 | DP | |
| 10849891 | 2038-08-27 | DP | U-1974 |
| 11452721 | 2038-08-27 | DP | |
| 10517860 | 2037-03-23 | U-1974 | |
| 10953000 | 2037-03-23 | U-1974 | |
| 7601740 | 2030-04-29 | DS, DP | |
| 7732615 | 2028-06-03 | DS, DP | |
| 7659285 | 2026-08-24 | U-1844 | |
| 7923564 | 2025-09-26 | DS, DP | |
| 8618130 | 2024-01-15 | U-1845 | |
| 8921393 | 2024-01-15 | U-1846 | |
| 9566271 | 2024-01-15 | U-1974 | |
| 10028944 | 2024-01-15 | U-1974 | |
HCPCS
No data
Clinical
Clinical Trials
43 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | 6 | 5 | 4 | 2 | 19 |
| Psychotic disorders | D011618 | — | F20.81 | — | 3 | 6 | 3 | 2 | 14 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 2 | 6 | 3 | 2 | 13 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | — | 1 | — | 2 | — | 3 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 1 | — | 2 | — | 3 |
| Traumatic stress disorders | D040921 | — | — | — | 1 | — | 2 | — | 3 |
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | — | 2 | 1 | — | 3 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | 1 | — | 2 |
| Lewy body disease | D020961 | EFO_0006792 | G31.83 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 3 | 3 | — | — | 6 |
| Depression | D003863 | — | F33.9 | — | 3 | 2 | — | — | 5 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 3 | 2 | — | — | 5 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 2 | 2 | — | — | 4 |
| Autistic disorder | D001321 | HP_0000717 | F84.0 | — | 3 | 2 | — | — | 3 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | — | 3 | 2 | — | — | 3 |
| Pervasive child development disorders | D002659 | EFO_0003756 | F84 | — | 3 | 2 | — | — | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 3 | — | — | — | 3 |
| Aggression | D000374 | EFO_0003015 | — | — | 3 | — | — | — | 3 |
| Impulse control disruptive and conduct disorders | D007174 | — | F63.2 | — | 2 | — | — | — | 2 |
| Dyskinesias | D020820 | HP_0002310 | G24 | 1 | 1 | — | — | — | 2 |
| Psychomotor agitation | D011595 | — | — | — | 2 | — | — | — | 2 |
| Hallucinations | D006212 | HP_0000738 | F06.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tourette syndrome | D005879 | EFO_0004895 | F95.2 | 1 | — | — | — | — | 1 |
| Tardive dyskinesia | D000071057 | — | G24.01 | 1 | — | — | — | — | 1 |
| Syndrome | D013577 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Pimavanserin |
| INN | pimavanserin |
| Description | Pimavanserin is a member of the class of ureas in which three of the four hydrogens are replaced by 4-fluorobenzyl, 1-methylpiperidin-4-yl, and 4-(isopropyloxy)benzyl groups. An atypical antipsychotic that is used (in the form of its tartrate salt) for treatment of hallucinations and delusions associated with Parkinson's disease. It has a role as an antipsychotic agent, a 5-hydroxytryptamine 2A receptor inverse agonist and a serotonergic antagonist. It is a member of ureas, a member of piperidines, a member of monofluorobenzenes, an aromatic ether and a tertiary amino compound. It is a conjugate base of a pimavanserin(1+). |
| Classification | Small molecule |
| Drug class | serotonin 5-HT2 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 706779-91-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2111101 |
| ChEBI ID | — |
| PubChem CID | 10071196 |
| DrugBank | DB05316 |
| UNII ID | JZ963P0DIK (ChemIDplus, GSRS) |
Target
Agency Approved
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
HTR2A
Gene synonyms
HTR2
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 2A
Protein synonyms
5-HT2 receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, serotonin 5-HT-2A receptor, Serotonin receptor 2A
Uniprot ID
Mouse ortholog
Htr2a (15558)
5-hydroxytryptamine receptor 2A (P35363)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 935 documents
View more details
Safety
Black-box Warning
Black-box warning for: Nuplazid
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
32,556 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use