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AboutPricing
Drug ReportsPilocarpine
Pilocarpine
Isopto Carpine, Pilo, Qlosi, Salagen, Vuity (pilocarpine) is a small molecule pharmaceutical. Pilocarpine was first approved as Ocusert pilo-20 on 1982-01-01. It is used to treat angle-closure glaucoma, head and neck neoplasms, mydriasis, and xerostomia in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M4.
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YTD
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FDA approval date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
stomatognathic diseasesD009057
eye diseasesD005128
Trade Name
FDA
EMA
Isopto carpine, Pilocarpine, Salagen, Vuity (discontinued: Ocusert pilo, Pilopine hs)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pilocarpine hydrochloride
Tradename
Company
Number
Date
Products
VUITYAbbVieN-214028 RX2021-10-28
1 products, RLD, RS
SALAGENADVANZ PHARMAN-020237 RX1994-03-22
2 products, RLD
ISOPTO CARPINESandozN-200890 RX2010-06-22
3 products, RLD, RS
Show 1 discontinued
Pilocarpine
Tradename
Company
Number
Date
Products
OCUSERT PILO-20Epic PharmaN-017431 DISCN1982-01-01
1 products
OCUSERT PILO-40Epic PharmaN-017548 DISCN1982-01-01
1 products
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Betaxolol hydrochloride
+
Pilocarpine hydrochloride
Tradename
Company
Number
Date
Products
BETOPTIC PILOAlcon ResearchN-020619 DISCN1997-04-17
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
betoptic pilo2006-06-19
pilocarpineunapproved drug other2011-12-02
pilocarpine hydrchlorideANDA2024-05-31
pilocarpine hydrochlorideANDA2025-08-25
pilocarpine hydrochloride ophthalmicANDA2025-06-02
qlosiNew Drug Application2025-05-30
salagenNew Drug Application2024-12-05
vuityNew Drug Application2023-03-28
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
head and neck neoplasms—D006258—
xerostomia—D014987K11.7
angle-closure glaucoma—D015812—
mydriasis—D015878H57.04
hypertensionEFO_0000537D006973I10
open-angle glaucomaEFO_0004190D005902H40.1
Agency Specific
FDA
EMA
Expiration
Code
PILOCARPINE HYDROCHLORIDE, VUITY, ABBVIE
2026-03-28D-187
2024-10-28NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Pilocarpine Hydrochloride, Vuity, Abbvie
106105182039-04-24U-3252, U-3561, U-3562
112851342039-04-24U-3252, U-3561, U-3562
ATC Codes
N: Nervous system drugs
— N07: Other nervous system drugs in atc
— N07A: Parasympathomimetics
— N07AX: Other parasympathomimetics in atc
— N07AX01: Pilocarpine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EB: Parasympathomimetics, antiglaucoma preparations and miotics
— S01EB01: Pilocarpine
— S01EB51: Pilocarpine, combinations
HCPCS
No data
Clinical
Clinical Trials
76 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PresbyopiaD011305—H52.4——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePilocarpine
INN—
Description
(+)-pilocarpine is the (+)-enantiomer of pilocarpine. It has a role as an antiglaucoma drug. It is an enantiomer of a (-)-pilocarpine.
Classification
Small molecule
Drug classtricyclic compounds
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C
Identifiers
PDB—
CAS-ID92-13-7
RxCUI—
ChEMBL IDCHEMBL550
ChEBI ID8207
PubChem CID5910
DrugBankDB01085
UNII ID—
Target
Agency Approved
No data
Alternate
CYP2A6
CYP2A6
Organism
Homo sapiens
Gene name
CYP2A6
Gene synonyms
CYP2A3
NCBI Gene ID
1548
Protein name
cytochrome P450 2A6
Protein synonyms
1,4-cineole 2-exo-monooxygenase, Coumarin 7-hydroxylase, CYPIIA6, Cytochrome P450 IIA3, Cytochrome P450(I), cytochrome P450, family 2, subfamily A, polypeptide 6, cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6, flavoprotein-linked monooxygenase, xenobiotic monooxygenase
Uniprot ID
Q9UK48
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Pilocarpine
+
Epinephrine
Total medical expenditures per year (USD, in millions)
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Pilocarpine
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 21,319 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,106 adverse events reported
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